3-Aryl-2-Quinolone Derivatives:  Synthesis and Characterization of In Vitro and In Vivo Antitumor Effects with Emphasis on a New Therapeutical Target Connected with Cell Migration

2002 ◽  
Vol 45 (12) ◽  
pp. 2543-2555 ◽  
Author(s):  
Benoît Joseph ◽  
Francis Darro ◽  
Aurélie Béhard ◽  
Brigitte Lesur ◽  
Françoise Collignon ◽  
...  
Keyword(s):  
Cell Migration ◽  
Synthesis And Characterization ◽  
Antitumor Effects ◽  
Quinolone Derivatives

Synthesis and Characterization of Dual Radiolabeled Layered Double Hydroxide Nanoparticles for Use in In Vitro and In Vivo Nanotoxicology Studies

2009 ◽  
Vol 114 (2) ◽  
pp. 734-740 ◽  
Author(s):  
Anthony W. Musumeci ◽  
Tara L. Schiller ◽  
Zhi Ping Xu ◽  
Rodney F. Minchin ◽  
Darren J. Martin ◽  
...  
Keyword(s):  
Layered Double Hydroxide ◽  
Synthesis And Characterization ◽  
Double Hydroxide ◽  
Layered Double Hydroxide Nanoparticles

Synthesis and characterization of surface‐modified PBLG nanoparticles for bone targeting: In vitro and in vivo evaluations

2011 ◽  
Vol 100 (11) ◽  
pp. 4877-4887 ◽  
Author(s):  
İpek Özcan ◽  
Kawthar Bouchemal ◽  
Freimar Segura‐Sánchez ◽  
Özgen Özer ◽  
Tamer Güneri ◽  
...  
Keyword(s):  
Synthesis And Characterization ◽  
Bone Targeting ◽  
Surface Modified

In Vitro and in Vivo Metabolism of Lu-AMBA, a GRP-Receptor Binding Compound, and the Synthesis and Characterization of Its Metabolites

2009 ◽  
Vol 20 (6) ◽  
pp. 1171-1178 ◽  
Author(s):  
Karen E. Linder ◽  
Edmund Metcalfe ◽  
Thangavel Arunachalam ◽  
Jianqing Chen ◽  
Stephen M. Eaton ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Synthesis And Characterization ◽  
In Vivo Metabolism ◽  
Grp Receptor

scholarly journals A Schistosoma japonicum MicroRNA Exerts Antitumor Effects Through Inhibition of Both Cell Migration and Angiogenesis by Targeting PGAM1

2021 ◽  
Vol 11 ◽  
Author(s):  
Chao Hu ◽  
Yuzhen Li ◽  
Danting Pan ◽  
Jing Wang ◽  
Liufang Zhu ◽  
...  
Keyword(s):  
Cell Migration ◽  
Schistosoma Japonicum ◽  
Therapeutic Potential ◽  
Hepatoma Cells ◽  
Phosphoglycerate Mutase ◽  
Human Hepatoma Cells ◽  
Antitumor Effects ◽  
Important Regulator

MicroRNA (miRNA) is an important regulator for gene expression. Recent studies showed that some heterogenous miRNAs derived from both parasite and plant can regulate expression of mammalian gene in a cross-species or even a cross-kingdom manner. Here, we identified a Schistosoma japonicum miRNA (designated as sja-miR-61) that is present in the hepatocyte of mice infected with the parasite. The sja-miR-61 mimics significantly inhibited the migration of both mouse and human hepatoma cells in vitro. In a xenograft animal model, significant reductions of the tumor volume and weight were observed in mice inoculated with hepatoma cells transfected with sja-miR-61 mimics compared to the controls. We found that the in vivo inhibition of tumor growth was through its anti-angiogenesis activity. Mechanically, we identified the phosphoglycerate mutase 1 (PGAM1) gene as a target of sja-miR-61 and found that the sja-miR-61-mediated suppression of cell migration and anti-angiogenesis by cross-species down-regulation of PGAM1 expression. These data indicated that sja-miR-61 is a tumor suppressor miRNA that may have therapeutic potential for human cancers.

scholarly journals Synthesis and characterization of near-infrared-emitting CdHgTe/CdS/ZnS quantum dots capped by N-acetyl-l-cysteine for in vitro and in vivo imaging

RSC Advances ◽  
2017 ◽  
Vol 7 (48) ◽  
pp. 29998-30007 ◽  
Author(s):  
Xijing Liu ◽  
Peijiang Zhou ◽  
Hongju Zhan ◽  
Hongyu Liu ◽  
Jianwei Zhang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Synthesis And Characterization

In this article, highly photoluminescent near-infrared (NIR)-emitting quantum dots (QDs) were directly synthesized in water by a fast, inexpensive and facile method.

scholarly journals Synthesis and Characterization of in Vitro and in Vivo Profiles of Hydroxybupropion Analogues: Aids to Smoking Cessation

2010 ◽  
Vol 53 (12) ◽  
pp. 4731-4748 ◽  
Author(s):  
Ronald J. Lukas ◽  
Ana Z. Muresan ◽  
M. Imad Damaj ◽  
Bruce E. Blough ◽  
Xiaodong Huang ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Synthesis And Characterization
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