Preparation and Characterization of Platinum(II) and (IV) Complexes of 1,3-Diaminepropane and 1,4-Diaminebutane:  Circumvention of Cisplatin Resistance and DNA Interstrand Cross-Link Formation in CH1cisR Ovarian Tumor Cells

2002 ◽  
Vol 45 (9) ◽  
pp. 1835-1844 ◽  
Author(s):  
Amparo Alvarez-Valdés ◽  
José Manuel Pérez ◽  
Isabel López-Solera ◽  
Raúl Lannegrand ◽  
José Manuel Continente ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Ovarian Tumor ◽  
Cisplatin Resistance ◽  
Cross Link ◽  
Link Formation ◽  
Ovarian Tumor Cells

Monoclonal antibodies against native ovarian tumor cells: specificity and characterization of the antigen. A preliminary report

1995 ◽  
Vol 121 (7) ◽  
pp. 387-392 ◽  
Author(s):  
Lina Wasserman ◽  
Alexander Neri ◽  
Bari Kaplan ◽  
Yoram Manor ◽  
Michal Galli ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Tumor Cells ◽  
Ovarian Tumor ◽  
Preliminary Report ◽  
Antigen A ◽  
Ovarian Tumor Cells

scholarly journals Characterization of Ascites-Derived Ovarian Tumor Cells from Spontaneously Occurring Ovarian Tumors of the Chicken: Evidence for E-Cadherin Upregulation

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e57582 ◽  
Author(s):  
Anupama Tiwari ◽  
Jill A. Hadley ◽  
Gilbert L. Hendricks ◽  
Robert G. Elkin ◽  
Timothy Cooper ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Ovarian Tumor ◽  
Ovarian Tumors ◽  
Ovarian Tumor Cells ◽  
E Cadherin

scholarly journals MicroRNAs as the critical regulators of Cisplatin resistance in ovarian cancer cells

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Meysam Moghbeli
Keyword(s):  
Ovarian Cancer ◽  
Tumor Cells ◽  
Treatment Option ◽  
Ovarian Tumor ◽  
Cisplatin Resistance ◽  
Present Review ◽  
Screening Methods ◽  
Non Invasive ◽  
Tumor Stages ◽  
Ovarian Tumor Cells

Abstract Background Ovarian cancer (OC) is one of the leading causes of cancer related deaths among women. Due to the asymptomatic tumor progression and lack of efficient screening methods, majority of OC patients are diagnosed in advanced tumor stages. A combination of surgical resection and platinum based-therapy is the common treatment option for advanced OC patients. However, tumor relapse is observed in about 70% of cases due to the treatment failure. Cisplatin is widely used as an efficient first-line treatment option for OC; however cisplatin resistance is observed in a noticeable ratio of cases. Regarding, the severe cisplatin side effects, it is required to clarify the molecular biology of cisplatin resistance to improve the clinical outcomes of OC patients. Cisplatin resistance in OC is associated with abnormal drug transportation, increased detoxification, abnormal apoptosis, and abnormal DNA repair ability. MicroRNAs (miRNAs) are critical factors involved in cell proliferation, apoptosis, and chemo resistance. MiRNAs as non-invasive and more stable factors compared with mRNAs, can be introduced as efficient markers of cisplatin response in OC patients. Main body In present review, we have summarized all of the miRNAs that have been associated with cisplatin resistance in OC. We also categorized the miRNAs based on their targets to clarify their probable molecular mechanisms during cisplatin resistance in ovarian tumor cells. Conclusions It was observed that miRNAs mainly exert their role in cisplatin response through regulation of apoptosis, signaling pathways, and transcription factors in OC cells. This review highlighted the miRNAs as important regulators of cisplatin response in ovarian tumor cells. Moreover, present review paves the way of suggesting a non-invasive panel of prediction markers for cisplatin response among OC patients.

scholarly journals ST6Gal-I sialyltransferase confers cisplatin resistance in ovarian tumor cells

2013 ◽  
Vol 6 (1) ◽  
pp. 25 ◽  
Author(s):  
Matthew J Schultz ◽  
Amanda F Swindall ◽  
John W Wright ◽  
Elizabeth S Sztul ◽  
Charles N Landen ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Ovarian Tumor ◽  
Cisplatin Resistance ◽  
St6gal I ◽  
Ovarian Tumor Cells

SV40 early genes induce neoplastic properties in serous borderline ovarian tumor cells

2008 ◽  
Vol 111 (1) ◽  
pp. 125-131 ◽  
Author(s):  
Michelle M. Woo ◽  
Clara M. Salamanca ◽  
Jaime Symowicz ◽  
M. Sharon Stack ◽  
Dianne M. Miller ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Ovarian Tumor ◽  
Borderline Ovarian Tumor ◽  
Early Genes ◽  
Ovarian Tumor Cells
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