Synthesis and Evaluation of a Novel Series of 2-Chloro-5-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-3-(2-(4-pyridinyl)vinyl)pyridine Analogues as Potential Positron Emission Tomography Imaging Agents for Nicotinic Acetylcholine Receptors

LaVerne L. Brown; Santosh Kulkarni; Olga A. Pavlova; Andrei O. Koren; Alexey G. Mukhin; Amy H. Newman; Andrew G. Horti

doi:10.1021/jm010550n

Synthesis and Evaluation of a Novel Series of 2-Chloro-5-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-3-(2-(4-pyridinyl)vinyl)pyridine Analogues as Potential Positron Emission Tomography Imaging Agents for Nicotinic Acetylcholine Receptors

Journal of Medicinal Chemistry ◽

10.1021/jm010550n ◽

2002 ◽

Vol 45 (13) ◽

pp. 2841-2849 ◽

Cited By ~ 18

Author(s):

LaVerne L. Brown ◽

Santosh Kulkarni ◽

Olga A. Pavlova ◽

Andrei O. Koren ◽

Alexey G. Mukhin ◽

...

Keyword(s):

Positron Emission Tomography ◽

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Imaging Agents ◽

Nicotinic Acetylcholine ◽

Tomography Imaging ◽

Positron Emission ◽

Vinyl Pyridine

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Derivatives of Dibenzothiophene for Positron Emission Tomography Imaging of α7-Nicotinic Acetylcholine Receptors

Journal of Medicinal Chemistry ◽

10.1021/jm401184f ◽

2013 ◽

Vol 56 (19) ◽

pp. 7574-7589 ◽

Cited By ~ 36

Author(s):

Yongjun Gao ◽

Kenneth J. Kellar ◽

Robert P. Yasuda ◽

Thao Tran ◽

Yingxian Xiao ◽

...

Keyword(s):

Positron Emission Tomography ◽

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Nicotinic Acetylcholine ◽

Tomography Imaging ◽

Positron Emission ◽

Α7 Nicotinic Acetylcholine Receptors ◽

Derivatives Of

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Derivatives of (−)-7-Methyl-2-(5-(pyridinyl)pyridin-3-yl)-7-azabicyclo[2.2.1]heptane Are Potential Ligands for Positron Emission Tomography Imaging of Extrathalamic Nicotinic Acetylcholine Receptors

Journal of Medicinal Chemistry ◽

10.1021/jm070224t ◽

2007 ◽

Vol 50 (16) ◽

pp. 3814-3824 ◽

Cited By ~ 8

Author(s):

Yongjun Gao ◽

Andrew G. Horti ◽

Hiroto Kuwabara ◽

Hayden T. Ravert ◽

John Hilton ◽

...

Keyword(s):

Positron Emission Tomography ◽

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Nicotinic Acetylcholine ◽

Tomography Imaging ◽

Positron Emission ◽

Derivatives Of

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Design, Synthesis, and Evaluation of (2-Aminocyclopropyl)phenyl Derivatives as Novel Positron Emission Tomography Imaging Agents for Lysine-Specific Demethylase 1 in the Brain

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c01937 ◽

2021 ◽

Vol 64 (7) ◽

pp. 3780-3793

Author(s):

Yasushi Hattori ◽

Satoru Matsuda ◽

Rina Baba ◽

Kouta Matsumiya ◽

Shinji Iwasaki ◽

...

Keyword(s):

Positron Emission Tomography ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Imaging Agents ◽

Design Synthesis ◽

Tomography Imaging ◽

Lysine Specific Demethylase ◽

Positron Emission ◽

The Brain

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LC-MS Supported Studies on the in Vitro Metabolism of both Enantiomers of Flubatine and the in Vivo Metabolism of (+)-[18F]Flubatine—A Positron Emission Tomography Radioligand for Imaging α4β2 Nicotinic Acetylcholine Receptors

Molecules ◽

10.3390/molecules21091200 ◽

2016 ◽

Vol 21 (9) ◽

pp. 1200 ◽

Cited By ~ 7

Author(s):

Friedrich-Alexander Ludwig ◽

René Smits ◽

Steffen Fischer ◽

Cornelius Donat ◽

Alexander Hoepping ◽

...

Keyword(s):

Positron Emission Tomography ◽

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

In Vitro Metabolism ◽

Emission Tomography ◽

In Vivo Metabolism ◽

Nicotinic Acetylcholine ◽

Positron Emission

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Discovery of (−)-7-Methyl-2-exo-[3′-(6-[18F]fluoropyridin-2-yl)-5′-pyridinyl]-7-azabicyclo[2.2.1]heptane, a Radiolabeled Antagonist for Cerebral Nicotinic Acetylcholine Receptor (α4β2-nAChR) with Optimal Positron Emission Tomography Imaging Properties

Journal of Medicinal Chemistry ◽

10.1021/jm800323d ◽

2008 ◽

Vol 51 (15) ◽

pp. 4751-4764 ◽

Cited By ~ 17

Author(s):

Yongjun Gao ◽

Hiroto Kuwabara ◽

Charles E. Spivak ◽

Yingxian Xiao ◽

Kenneth Kellar ◽

...

Keyword(s):

Positron Emission Tomography ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Nicotinic Acetylcholine ◽

Tomography Imaging ◽

Positron Emission ◽

Imaging Properties

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Copper, gallium and zirconium positron emission tomography imaging agents: The importance of metal ion speciation

Coordination Chemistry Reviews ◽

10.1016/j.ccr.2017.05.011 ◽

2017 ◽

Vol 352 ◽

pp. 499-516 ◽

Cited By ~ 17

Author(s):

Lachlan E. McInnes ◽

Stacey E. Rudd ◽

Paul S. Donnelly

Keyword(s):

Positron Emission Tomography ◽

Metal Ion ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Imaging Agents ◽

Tomography Imaging ◽

Positron Emission ◽

Metal Ion Speciation

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Synthesis and evaluation of new radioligands [11C]A-833834 and [11C]A-752274 for positron-emission tomography of α7-nicotinic acetylcholine receptors

Nuclear Medicine and Biology ◽

10.1016/j.nucmedbio.2012.11.013 ◽

2013 ◽

Vol 40 (3) ◽

pp. 395-402 ◽

Cited By ~ 13

Author(s):

Andrew G. Horti ◽

Hayden T. Ravert ◽

Yongjun Gao ◽

Daniel P. Holt ◽

William H. Bunnelle ◽

...

Keyword(s):

Positron Emission Tomography ◽

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Emission Tomography ◽

Nicotinic Acetylcholine ◽

Positron Emission ◽

Α7 Nicotinic Acetylcholine Receptors

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Synthesis and Evaluation of18F-Labeled 2-Phenylbenzothiazoles as Positron Emission Tomography Imaging Agents for Amyloid Plaques in Alzheimer’s Disease

Journal of Medicinal Chemistry ◽

10.1021/jm8013376 ◽

2009 ◽

Vol 52 (5) ◽

pp. 1428-1437 ◽

Cited By ~ 57

Author(s):

Kim Serdons ◽

Christelle Terwinghe ◽

Peter Vermaelen ◽

Koen Van Laere ◽

Hank Kung ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Positron Emission Tomography ◽

Positron Emission Tomography Imaging ◽

Amyloid Plaques ◽

Emission Tomography ◽

Imaging Agents ◽

Tomography Imaging ◽

Positron Emission

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ChemInform Abstract: Synthesis and Biological Activity of Fluoro-Substituted Pyrrolo[2,3-d]pyrimidines. The Development of Potential Positron Emission Tomography Imaging Agents for the Corticotropin-Releasing Hormone Type 1 Receptor.

ChemInform ◽

10.1002/chin.200029121 ◽

2010 ◽

Vol 31 (29) ◽

pp. no-no

Author(s):

Ling-Wei Hsin ◽

Elizabeth L. Webster ◽

George P. Chrousos ◽

Philip W. Gold ◽

William C. Eckelman ◽

...

Keyword(s):

Positron Emission Tomography ◽

Biological Activity ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Imaging Agents ◽

Corticotropin Releasing Hormone ◽

Releasing Hormone ◽

Tomography Imaging ◽

Positron Emission

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Cerebral nicotinic acetylcholine receptors in patients with Alzheimer's disease or vascular dementia - evaluation with 2-[18F]F-A85380 and positron emission tomography (PET)

Journal of Cerebral Blood Flow & Metabolism ◽

10.1038/sj.jcbfm.9591524.0580 ◽

2005 ◽

Vol 25 (1_suppl) ◽

pp. S580-S580

Author(s):

Kai Kendziorra ◽

Philipp Meyer ◽

Henryk Barthel ◽

Georg Becker ◽

Dietlind Sorger ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Positron Emission Tomography ◽

Vascular Dementia ◽

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Emission Tomography ◽

Nicotinic Acetylcholine ◽

Positron Emission

Download Full-text