Design and synthesis of naltrexone-derived affinity labels with nonequilibrium opioid agonist and antagonist activities. Evidence for the existence of different .mu. receptor subtypes in different tissues

1984 ◽  
Vol 27 (10) ◽  
pp. 1325-1335 ◽  
Author(s):  
L. M. Sayre ◽  
D. L. Larson ◽  
A. E. Takemori ◽  
P. S. Portoghese
Keyword(s):  
Receptor Subtypes ◽  
Opioid Agonist ◽  
Affinity Labels ◽  
Design And Synthesis ◽  
Mu Receptor ◽  
Agonist And Antagonist ◽  
Different Tissues

Design and Synthesis of 4-Phenyl Piperidine Compounds Targeting the Mu Receptor.

ChemInform ◽  
2005 ◽  
Vol 36 (9) ◽  
Author(s):  
Zhengming Chen ◽  
Ellen Davies ◽  
Wendy S. Miller ◽  
Shen Shan ◽  
Kenneth J. Valenzano ◽  
...  
Keyword(s):  
Design And Synthesis ◽  
Mu Receptor

Opioid agonist and antagonist activities of peripherally selective derivatives of naltrexamine and oxymorphamine

1989 ◽  
Vol 32 (9) ◽  
pp. 2068-2071 ◽  
Author(s):  
S. Botros ◽  
A. W. Lipkowski ◽  
D. L. Larson ◽  
P. A. Stark ◽  
A. E. Takemori ◽  
...  
Keyword(s):  
Opioid Agonist ◽  
Agonist And Antagonist ◽  
Derivatives Of

Stereostructure-activity relationship of opioid agonist and antagonist bivalent ligands. Evidence for bridging between vicinal opioid receptors

1985 ◽  
Vol 28 (9) ◽  
pp. 1140-1141 ◽  
Author(s):  
P. S. Portoghese ◽  
D. L. Larson ◽  
C. B. Yim ◽  
L. M. Sayre ◽  
G. Ronsisvalle ◽  
...  
Keyword(s):  
Opioid Receptors ◽  
Activity Relationship ◽  
Bivalent Ligands ◽  
Opioid Agonist ◽  
Agonist And Antagonist ◽  
Relationship Of

Insights into the Structural Aspects of the mGlu Receptor Orthosteric Binding Site

2019 ◽  
Vol 19 (26) ◽  
pp. 2421-2446 ◽  
Author(s):  
Junliang Hao ◽  
Qi Chen
Keyword(s):  
Binding Pocket ◽  
Receptor Subtypes ◽  
X Ray ◽  
Mglu Receptor ◽  
Metabotropic Glutamate ◽  
Amino Terminal ◽  
Subtype Selectivity ◽  
Agonist And Antagonist ◽  
Amino Terminal Domain ◽  
Structural Aspects

The amino terminal domain (ATD) of the metabotropic glutamate (mGlu) receptors contains the orthosteric glutamate recognition site, which is highly conserved across the eight mGlu receptor subtypes. In total, 29 X-ray crystal structures of the mGlu ATD proteins have been reported to date. These structures span across 3 subgroups and 6 subtypes, and include apo, agonist- and antagonist-bound structures. We will discuss the insights gained from the analysis of these structures with the focus on the interactions contributing to the observed group and subtype selectivity for select agonists. Furthermore, we will define the full expanded orthosteric ligand binding pocket (LBP) of the mGlu receptors, and discuss the macroscopic features of the mGlu ATD proteins.

The cardiovascular responses to mu opioid agonist and antagonist in conscious normal and obese rats

Peptides ◽  
2006 ◽  
Vol 27 (6) ◽  
pp. 1520-1526 ◽  
Author(s):  
Crystal Hill-Pryor ◽  
DaShawnda Lindsey ◽  
Karen Lapanowski ◽  
Joseph C. Dunbar
Keyword(s):  
Cardiovascular Responses ◽  
Opioid Agonist ◽  
Mu Opioid ◽  
Obese Rats ◽  
Agonist And Antagonist
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