Potential Inhibitors of Cancerous Growth. V. Substituted Benzylidene Derivatives of D-Ribose as Synthetic Intermediates

1965 ◽  
Vol 8 (6) ◽  
pp. 889-891 ◽  
Author(s):  
W. J. Serfontein ◽  
G. J. Lourens ◽  
H. L. De Waal
Keyword(s):  
Synthetic Intermediates ◽  
Potential Inhibitors ◽  
Derivatives Of

Phosphonate monoesters on a thiacalix[4]arene framework as potential inhibitors of protein tyrosine phosphatase 1B

2015 ◽  
Vol 13 (33) ◽  
pp. 8803-8806 ◽  
Author(s):  
Viacheslav V. Trush ◽  
Sergiy G. Kharchenko ◽  
Vsevolod Yu. Tanchuk ◽  
Vitaly I. Kalchenko ◽  
Andriy I. Vovk
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Methylphosphonic Acid ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Potential Inhibitors ◽  
Derivatives Of

Monoester derivatives of thiacalix[4]arene tetrakis(methylphosphonic) acid were found to be capable of inhibiting protein tyrosine phosphatase 1B. In addition, these compounds can strongly bind to human serum albumin.

PHOSPHORAMIDATE DERIVATIVES OF 2′,5′-DIDEOXYADENOSINE AS POTENTIAL INHIBITORS OF THE EDHF PHENOMENON

2005 ◽  
Vol 24 (5-7) ◽  
pp. 553-555 ◽  
Author(s):  
F. Gavazza ◽  
F. Daverio ◽  
A. T. Chaytor ◽  
T. M. Griffith ◽  
C. McGuigan
Keyword(s):  
Potential Inhibitors ◽  
Derivatives Of

Synthesis of cyclopentane analogs of (2′- and 3′-deoxy-erythro-pentofuranosyl and ribofuranosyl)-2-thiouracil nucleosides

1986 ◽  
Vol 64 (8) ◽  
pp. 1620-1629 ◽  
Author(s):  
Lucjan J.J. Hronowski ◽  
Walter A. Szarek
Keyword(s):  
Sulfur Atom ◽  
Nmr Spectra ◽  
Aqueous Ammonia ◽  
Synthetic Route ◽  
Nmr Spectrum ◽  
H Nmr ◽  
Synthetic Intermediates ◽  
Derivatives Of ◽  
Sulfur Containing ◽  
Sulfur Containing Compounds

Three new carbocyclic analogs of nucleosides having the 2-thiouracil base have been synthesized. The cyclopentyl groups in these nucleosides are (±)-{(1β,3α,4β)-3-hydroxy-4-(hydroxyrnethyl)cyclopentyl} (see 31), (±)-{(1β,2α,4β)-2-hydroxy-4-(hydroxymethyl)cyclopentyl} (see 32), and (±)-{(1β,2α,3α,4β)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl} (see 33). The nucleosides were prepared by coupling the appropriate hydroxy derivatives of cis-3-aminocyclopentanemethanol with 3-ethoxypropenoyl isothiocyanate (21) followed by cyclization in 15 N aqueous ammonia to give the 2-thiouracil nucleosides. In addition a modified and shortened synthetic route is described for the synthesis of (±)-(1β,2α,3α,4β)-4-amino-2,3-dihydroxy-cyclopentanemethanol (19). The 1H nmr spectra at 200 MHz of all of the synthetic intermediates, the 2-thiouracil nucleosides, and of the corresponding carbocyclic analogs of uracil nucleosides are discussed. It is shown that each nucleoside has a characteristically unique 1H nmr spectrum and that in general the protons in the sulfur-containing compounds resonate at lower fields than those in the corresponding oxygen-containing compounds. The magnitude of this downfield shift is inversely related to the number of bonds separating a particular proton from the sulfur atom.

Phosphonate derivatives of tetraazamacrocycles as new inhibitors of protein tyrosine phosphatases

2015 ◽  
Vol 13 (27) ◽  
pp. 7437-7444 ◽  
Author(s):  
Oleksandr L. Kobzar ◽  
Michael V. Shevchuk ◽  
Alesya N. Lyashenko ◽  
Vsevolod Yu. Tanchuk ◽  
Vadim D. Romanenko ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatases ◽  
Tyrosine Phosphatases ◽  
Protein Tyrosine ◽  
Potential Inhibitors ◽  
Derivatives Of

α,α-Difluoro-β-ketophosphonate derivatives of tetraazamacrocycles were synthesized and found to be potential inhibitors of protein tyrosine phosphatases.

Derivatives of 7-oxabicyclo[2.2.1]heptane in nature and as useful synthetic intermediates

Tetrahedron ◽  
1999 ◽  
Vol 55 (48) ◽  
pp. 13521-13642 ◽  
Author(s):  
Pierre Vogel ◽  
Janine Cossy ◽  
Joaquín Plumet ◽  
Odón Arjona
Keyword(s):  
Synthetic Intermediates ◽  
Derivatives Of

Synthesis of Hallachrome

1999 ◽  
Vol 52 (9) ◽  
pp. 833 ◽  
Author(s):  
Donald W. Cameron ◽  
D. Ross Coller ◽  
Clinton A. McDonald
Keyword(s):  
Naturally Occurring ◽  
Synthetic Intermediates ◽  
Derivatives Of

Hallachrome (1), the only known example of a naturally occurring 1,2-anthraquinone, has been synthesized by successive cycloadditions involving the dienophile (8) with the dienes (7) and (12). Synthetic intermediates (18) and (6) are known derivatives of natural hallachrome.

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