Synthesis of compounds with potential central nervous system stimulant activity. I. 2-Amino-2-oxazolin-4-one-5-spirocycloalkanes and 2-amino-2-oxazolin-4-one-5-spiro(4'-piperidines)

1969 ◽  
Vol 12 (5) ◽  
pp. 919-921 ◽  
Author(s):  
Michael R. Harnden ◽  
Ray R. Rasmussen
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Stimulant

CNS Stimulant Controversies

1989 ◽  
Vol 23 (4) ◽  
pp. 497-502 ◽  
Author(s):  
Florence Levy
Keyword(s):  
Central Nervous System ◽  
Animal Model ◽  
Nervous System ◽  
High Dose ◽  
Ethical Considerations ◽  
Hyperactivity Disorder ◽  
Central Nervous System Stimulant ◽  
Stimulant Medications ◽  
Cns Stimulant

Controversies in the use of central nervous system stimulant medications in children with attention deficit hyperactivity disorder are discussed. Diagnostic issues, age of optimal use, side effects, effects on learning and ethical considerations are current issues. An animal model for the effects of chronic long-term high dose regimes is proposed.

scholarly journals Degradative Studies in the Picrotoxinin Series

2021 ◽  
Author(s):  
◽  
Raymond Maurice Carman
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
High Oxygen Content ◽  
East Indies ◽  
Central Nervous System Stimulant ◽  
Bitter Principle ◽  
Elementary Analysis ◽  
Fish Poison ◽  
Barbiturate Poisoning ◽  
Convulsant Drug

<p>PICROTOXIN is a bitter principle of the berries of the species Mensiperum coculus and Anamirata coculus, creepers which are indigenous to the East Indies. It was first isolated in 1812, and subsequent elementary analysis showed that it contained only carbon, hydrogen, and oxygen. Because of its potent poisonous nature and its physiological action, together with its high oxygen content, picrotoxin has often been referred to as an “oxygen alkaloid”. It is a central nervous system stimulant and a powerful convulsant drug. It is used in medicine as an antidote to barbiturate poisoning, being still preferred for this purpose over many other drugs. It has also been used in cases of alcoholic intoxication, and as a fish poison.</p>

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