Irreversible enzyme inhibitors. CLXXIV. Metabolism of 4-[p-(4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazin-1-yl)hydrocinnamido]-o-toluenesulfonyl fluoride (NSC-113423), and active-site-directed irreversible inhibitor of dihydrofolic reductase

Bernard Randall Baker; Adrian J. Ryan; Nicolaas M. J. Vermeulen

doi:10.1021/jm00300a027

Irreversible enzyme inhibitors. CLXXIV. Metabolism of 4-[p-(4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazin-1-yl)hydrocinnamido]-o-toluenesulfonyl fluoride (NSC-113423), and active-site-directed irreversible inhibitor of dihydrofolic reductase

Journal of Medicinal Chemistry ◽

10.1021/jm00300a027 ◽

1970 ◽

Vol 13 (6) ◽

pp. 1140-1142 ◽

Cited By ~ 9

Author(s):

Bernard Randall Baker ◽

Adrian J. Ryan ◽

Nicolaas M. J. Vermeulen

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitor

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Irreversible enzyme inhibitors 100 Inhibitors of thymidine phosphorylase 8. 6-(p-bromoacetamido-benzyl)uracil, an active-site-directed irreversible inhibitor

Journal of Pharmaceutical Sciences ◽

10.1002/jps.2600560907 ◽

1967 ◽

Vol 56 (9) ◽

pp. 1086-1092 ◽

Cited By ~ 4

Author(s):

B.R. Baker ◽

Mitsutaka Kawazu

Keyword(s):

Active Site ◽

Thymidine Phosphorylase ◽

Enzyme Inhibitors ◽

Irreversible Inhibitor

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Irreversible enzyme inhibitors. CXXXIX. p-(4,6-Diamino-1,2-dihydro-2,2-dimethyl-s-triazin-1-yl)phenylpropionylsulfanilyl fluoride, an active-site-directed irreversible inhibitor of dihydrofolic reductase. 6. Effects of substitution on the propionamide bridge on isozyme specificity

Journal of Medicinal Chemistry ◽

10.1021/jm00301a024 ◽

1969 ◽

Vol 12 (1) ◽

pp. 92-94

Author(s):

Bernard Randall Baker ◽

Gerhardus J. Lourens

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitor

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Irreversible enzyme inhibitors. CXXIX. p-(4,6-Diamino-1,2-dihydro-2,2-dimethyl-s-triazine-l-yl)phenylpropionylsulfanilyl fluoride, an active site-directed irreversible inhibitor of dihydrofolic reductase. 5. Effects of substitution on the benzenesulfonyl fluoride moiety on isozyme specificity

Journal of Medicinal Chemistry ◽

10.1021/jm00310a009 ◽

1968 ◽

Vol 11 (4) ◽

pp. 677-682 ◽

Cited By ~ 5

Author(s):

B. R. Baker ◽

Gerhardus J. Lourens

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitor

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Irreversible Enzyme Inhibitors. XCV. 8-(m-Bromoacetamidobenzylthio)hypoxanthine, an Active-Site-Directed Irreversible Inhibitor of Xanthine Oxidase1-3

Journal of Medicinal Chemistry ◽

10.1021/jm00316a035 ◽

1967 ◽

Vol 10 (4) ◽

pp. 682-685 ◽

Cited By ~ 5

Author(s):

B. R. Baker ◽

Janos. Kozma

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitor

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Irreversible Enzyme Inhibitors. CVIII.1,26-(p-Chloroacetylanilinomethyl)-5-(p-chlorophenyl)-2, 4-diaminopyrimidine, an Active-Site-Directed Irreversible Inhibitor of Dihydrofolic Reductase

Journal of Medicinal Chemistry ◽

10.1021/jm00318a032 ◽

1967 ◽

Vol 10 (6) ◽

pp. 1134-1138 ◽

Cited By ~ 1

Author(s):

B. R. Baker ◽

Ping Cheong. Huang ◽

Alfonso L. Pogolotti

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitor

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Enzyme Inhibitors. XIII. The Synthesis of an Active-Site-Directed Irreversible Inhibitor of Adenosine Deaminase1

Journal of Medicinal Chemistry ◽

10.1021/jm00322a030 ◽

1966 ◽

Vol 9 (4) ◽

pp. 576-581 ◽

Cited By ~ 22

Author(s):

Howard J. Schaeffer ◽

Eugene Odin

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitor

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Irreversible enzyme inhibitors. CXXVIII. p-(4,6-Diamino-1,2-dihydro-2,2-dimethyl-s-triazin-l-yl)phenylpropionylsulfanilyl fluoride, an active site-directed irreversible inhibitor of dihydrofolic reductase. 4. Effects of substitution on the propionamide bridge on isozyme specificity

Journal of Medicinal Chemistry ◽

10.1021/jm00310a008 ◽

1968 ◽

Vol 11 (4) ◽

pp. 672-677 ◽

Cited By ~ 1

Author(s):

B. R. Baker ◽

Gerhardus J. Lourens

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitor

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Irreversible enzyme inhibitors. CLIX. Effect of substitution on transport and isozyme specificity of p-(4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazin-1-yl)-o-chlorophenoxyacetamido-benzenesulfonyl fluoride, an active-site-directed irreversible inhibitor of dihydrofolic reductase

Journal of Medicinal Chemistry ◽

10.1021/jm00305a042 ◽

1969 ◽

Vol 12 (5) ◽

pp. 894-897 ◽

Cited By ~ 1

Author(s):

Bernard Randall Baker ◽

Wallace T. Ashton

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitor

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Enzyme Inhibitors XII. Synthesis of an Active-Site-Directed Irreversible Inhibitor of Adenosine Deaminase

Journal of Pharmaceutical Sciences ◽

10.1002/jps.2600540834 ◽

1965 ◽

Vol 54 (8) ◽

pp. 1223-1224 ◽

Cited By ~ 7

Author(s):

Howard J. Schaeffer ◽

Eugene Odin

Keyword(s):

Adenosine Deaminase ◽

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitor

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Irreversible enzyme inhibitors. CXXXVI. 2,4-Diamino-5-(3,4-dichlorophenyl)-6-[p-(m-fluorosulfonylbenzamido)phenoxymethyl]pyrimidine, an active-site-directed irreversible inhibitor of dihydrofolic reductase. Effect of structure on isozyme specificity

Journal of Medicinal Chemistry ◽

10.1021/jm00301a021 ◽

1969 ◽

Vol 12 (1) ◽

pp. 82-85 ◽

Cited By ~ 1

Author(s):

Bernard Randall Baker ◽

Nicolaas M. J. Vermeulen

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitor ◽

Effect Of Structure

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