Antimalarial compounds. 12. Guanidine derivatives of diphenyl sulfone and related compounds

1972 ◽  
Vol 15 (2) ◽  
pp. 204-206 ◽  
Author(s):  
W. Peters ◽  
H. Piotrowska ◽  
B. Serafin ◽  
T. Urbanski
Keyword(s):  
Guanidine Derivatives ◽  
Diphenyl Sulfone ◽  
Derivatives Of ◽  
Related Compounds ◽  
Antimalarial Compounds

Synthetic studies of hydrazine and guanidine: derivatives of 5-pyrazoles

1968 ◽  
Vol 46 (7) ◽  
pp. 1079-1091 ◽  
Author(s):  
Joseph Zauhar ◽  
Benoit F. Ladouceur
Keyword(s):  
Hydrazine Hydrate ◽  
Dimethyl Formamide ◽  
Condensation Products ◽  
Guanidine Derivatives ◽  
Synthetic Studies ◽  
Derivatives Of ◽  
Related Compounds ◽  
Reaction Schemes

The reactions of several substituted 5-chloropyrazoles with hydrazine hydrate and guanidine, respectively, were investigated in ethanol and dimethyl formamide media. In certain cases, only SN2 reactions occurred, while in others the 5-hydrazino- and 5-guanidopyrazoles reacted still further to yield related compounds with two pyrazole rings. On the basis of the intermediates and the different condensation products isolated, reaction schemes are proposed for the reactions discussed.

Synthesis of 5,7-dihydroxynaphthoquinone derivatives and their reactions with nucleophiles: Nitration of 2,3-dimethylnaphthalene and subsequent transformations

1976 ◽  
Vol 29 (10) ◽  
pp. 2247 ◽  
Author(s):  
HJ Banks ◽  
DW Cameron ◽  
MJ Crossley ◽  
EL Samuel
Keyword(s):  
Unusual Reaction ◽  
Nitro Derivatives ◽  
Reactions With Nucleophiles ◽  
Derivatives Of ◽  
Related Compounds ◽  
Benzenoid Ring

5,7-Dihydroxy-2,3-dimethyl-l,4-naphthoquinone (5) and related compounds have been synthesized. The quinone affords an accessible substrate for studying an unusual reaction with nucleophiles, which involves attack at the 8-position, i.e. at the benzenoid ring. An unsuccessful approach to (5) has led to tri- and tetra-nitro derivatives of 2,3-dimethylnaphthalene. Reduction of the former and subsequent conversions have given aminonaphthoquinone and perimidinone derivatives.

A synthesis of alkylated 3-aminoisoquinolines and related compounds

1982 ◽  
Vol 35 (7) ◽  
pp. 1391 ◽  
Author(s):  
AJ Liepa
Keyword(s):  
Phosphoryl Chloride ◽  
Tertiary Amides ◽  
Derivatives Of ◽  
Related Compounds ◽  
Selection Of

N,N-Dialkyl derivatives of 3-aminoisoquinoline have been prepared by reaction of nitriles with various arylacetic acid tertiary amides in the presence of phosphoryl chloride. The synthesis has been extended to include a benzoisoquinoline and annulated isoquinolines by the selection of appropriate amide and nitrile precursors.

scholarly journals Epoxy derivatives of aromatic polycyclic hydrocarbons. The preparation of benz[a]anthracene 8,9-oxide and 10,11-dihydrobenz[a]anthracene 8,9-oxide and their metabolism by rat liver preparations

1971 ◽  
Vol 125 (1) ◽  
pp. 159-168 ◽  
Author(s):  
P. Sims
Keyword(s):  
Rat Liver ◽  
Reduced Glutathione ◽  
Mercapturic Acids ◽  
Polycyclic Hydrocarbons ◽  
Glutathione Conjugates ◽  
Liver Homogenates ◽  
Derivatives Of ◽  
Related Compounds

The syntheses of 10,11-dihydrobenz[a]anthracene 8,9-oxide, benz[a]anthracene 8,9-oxide and 9-hydroxybenz[a]anthracene are described, together with those of a number of related compounds. The epoxides react both chemically and enzymically with water to yield the corresponding dihydrodiols and with reduced glutathione to form glutathione conjugates, and they react chemically with N-acetylcysteine to yield the corresponding mercapturic acids. 8,9-Dihydro-8,9-dihydroxybenz[a]anthracene, formed enzymically from benz[a]anthracene 8,9-oxide, was identical with a dihydrodiol formed when benz[a]anthracene was metabolized by rat liver homogenates. Similarly 10,11-dihydrobenz[a]anthracene 8,9-oxide yielded a dihydrodiol identical with the product formed when 10,11-dihydrobenz[a]anthracene was metabolized.

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