Antianaphylactic agents. 4. Synthesis and structure-activity relations of 3-(4-oxo-4H-1-benzopyran-3)acrylic acids, a new series of antiallergic substances, and some related compounds

1975 ◽  
Vol 18 (1) ◽  
pp. 34-37 ◽  
Author(s):  
Akira Nohara ◽  
Hisashi Kuriki ◽  
Taketoshi Saijo ◽  
Kiyoshi Ukawa ◽  
Tadakazu Murata ◽  
...  
Keyword(s):  
Structure Activity ◽  
Structure Activity Relations ◽  
Acrylic Acids ◽  
Related Compounds

Ferguson's Principle and the Prediction of Fatal Drug Levels in Blood

1985 ◽  
Vol 4 (3) ◽  
pp. 273-278 ◽  
Author(s):  
L.A. King
Keyword(s):  
Drug Toxicity ◽  
Quantitative Structure ◽  
Drug Levels ◽  
A Value ◽  
Structure Activity ◽  
Structure Activity Relations ◽  
The Mean ◽  
Broad Framework ◽  
Aqueous Solubilities ◽  
Related Compounds

1 The median fatal concentrations (EC50) of various types of drugs are shown to be determined solely by their aqueous solubilities (S). Among the test substances, EC50 values show a range of 2000-fold, whereas the ratio EC 50/S is essentially constant. This behaviour is typical of 'Ferguson substances', and enables the fatal toxicity of other (depressant) drugs and related compounds to be calculated. 2 The mean relative saturation (EC50/S) is 0.006, a value which shows that humans are more sensitive to narcotic agents than are the lower animals. 3 The Ferguson principle provides a broad framework for quantitative structure-activity relations in fatal drug toxicity. The empirical Hansch equation can be derived from the same thermodynamic concept of free energy which underlies the Ferguson principle.

Amidines and related compounds. 6. Structure-activity relations of antihypertensive and antisecretory agents related to clonidine

1975 ◽  
Vol 18 (1) ◽  
pp. 90-99 ◽  
Author(s):  
Timothy Jen ◽  
Helene Van Hoeven ◽  
William Groves ◽  
Richard A. McLean ◽  
Bernard Loev
Keyword(s):  
Structure Activity ◽  
Structure Activity Relations ◽  
Related Compounds

Synthesis and structure-activity relations of disodium cromoglycate and some related compounds

1972 ◽  
Vol 15 (6) ◽  
pp. 583-589 ◽  
Author(s):  
H. Cairns ◽  
C. Fitzmaurice ◽  
D. Hunter ◽  
P. B. Johnson ◽  
J. King ◽  
...  
Keyword(s):  
Disodium Cromoglycate ◽  
Structure Activity ◽  
Structure Activity Relations ◽  
Related Compounds
Sign in / Sign up

Export Citation Format

Share Document