Quantitative structure-activity relations among steroids. Investigations of the use of steric parameters

1976 ◽  
Vol 19 (6) ◽  
pp. 748-754 ◽  
Author(s):  
Robert A. Coburn ◽  
Alan J. Solo
Keyword(s):  
Quantitative Structure ◽  
Structure Activity ◽  
Structure Activity Relations

Ferguson's Principle and the Prediction of Fatal Drug Levels in Blood

1985 ◽  
Vol 4 (3) ◽  
pp. 273-278 ◽  
Author(s):  
L.A. King
Keyword(s):  
Drug Toxicity ◽  
Quantitative Structure ◽  
Drug Levels ◽  
A Value ◽  
Structure Activity ◽  
Structure Activity Relations ◽  
The Mean ◽  
Broad Framework ◽  
Aqueous Solubilities ◽  
Related Compounds

1 The median fatal concentrations (EC50) of various types of drugs are shown to be determined solely by their aqueous solubilities (S). Among the test substances, EC50 values show a range of 2000-fold, whereas the ratio EC 50/S is essentially constant. This behaviour is typical of 'Ferguson substances', and enables the fatal toxicity of other (depressant) drugs and related compounds to be calculated. 2 The mean relative saturation (EC50/S) is 0.006, a value which shows that humans are more sensitive to narcotic agents than are the lower animals. 3 The Ferguson principle provides a broad framework for quantitative structure-activity relations in fatal drug toxicity. The empirical Hansch equation can be derived from the same thermodynamic concept of free energy which underlies the Ferguson principle.

scholarly journals Quantitative Structure-activity Relations in Pyrazolylpyrimidine Derivatives for Their Analgesic Activities

1982 ◽  
Vol 55 (5) ◽  
pp. 1489-1492 ◽  
Author(s):  
Yoshikatsu Miyashita ◽  
Tomoko Seki ◽  
Yasuhiko Yotsui ◽  
Ken-ichi Yamazaki ◽  
Mitsuji Sano ◽  
...  
Keyword(s):  
Quantitative Structure ◽  
Structure Activity ◽  
Structure Activity Relations ◽  
Analgesic Activities

Steric Fit in Quantitative Structure-Activity Relations

1980 ◽  
Author(s):  
Alexandru T. Balaban ◽  
Adrian Chiriac ◽  
Ioan Motoc ◽  
Zeno Simon
Keyword(s):  
Quantitative Structure ◽  
Structure Activity ◽  
Structure Activity Relations
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