Replacement of the disulfide bond in oxytocin by an amide group. Synthesis and some biological properties of [cyclo-(1-L-aspartic acid, 6-L-.alpha.,.beta.-diaminopropionic acid)]oxytocin

1978 ◽  
Vol 21 (1) ◽  
pp. 117-120 ◽  
Author(s):  
Clark W. Smith ◽  
Roderich Walter ◽  
Stanley Moore ◽  
Raymond C. Makofske ◽  
Johannes Meienhofer
Keyword(s):  
Aspartic Acid ◽  
Disulfide Bond ◽  
Biological Properties ◽  
Amide Group ◽  
Alpha Beta ◽  
Diaminopropionic Acid

Synthesis and Biological Properties of some New Lead Sulphonamide and Carboxamide Scaffolds Bearing Coumarin Moiety (Mini Review)

2020 ◽  
Vol 20 ◽  
Author(s):  
Cosmas Chinweike Eze ◽  
Mercy Amarachukwu Ezeokonkwo ◽  
Benjamin Ebere Ezema ◽  
Abraham Efeturi Onoabedje ◽  
David Izuchukwu Ugwu
Keyword(s):  
Biological Properties ◽  
Therapeutic Agents ◽  
Amide Group ◽  
Pharmacological Properties ◽  
Important Class ◽  
Synthetic Route ◽  
Therapeutic Activities

: Coumarin, sulphonamide and amide scaffolds exhibit diverse pharmacological features and constitute an important class of therapeutic agents. In this review, we have discussed the synthesis, biological properties, and SAR of coumarins containing sulphonamide or amide group in the last seven years. Many reviews on the therapeutic activities of coumarins, sulphonamides, and amides have been published, hence the authors focused on coumarin-linked sulphonamide or amide scaffolds. The review provides information on the synthetic route to new coumarins containing sulphonamide or amide groups with improved pharmacological properties.

CHEMICAL AND BIOLOGICAL PROPERTIES OF CULTURE FILTRATES OF WESTIELLOPSIS PROLIFICA AND CHAETOPHORA ATTENUATA

1996 ◽  
Vol 44 (1) ◽  
pp. 43-48 ◽  
Author(s):  
S.C. Agrawal ◽  
U.K. Sharma
Keyword(s):  
Amino Acids ◽  
Aspartic Acid ◽  
Free Amino ◽  
Biological Properties ◽  
Total Chlorophyll ◽  
Total Chlorophyll Content ◽  
Westiellopsis Prolifica ◽  
Total Free Amino Acids ◽  
Zoospore Formation ◽  
Growth And Reproduction

Westiellopsis prolifica Janet and Chaetophora attenuata Hazen cultures released sugars (glucose, fructose, and sucrose), organic acids (oxaloacetic acid and oxalic acid), amino acids, and protein. W. prolifica cultures released the amino acids glycine, serine, cystine, glutamic acid, aspartic acid, and α-alanine, while C. attenuata cultures released glycine, serine, aspartic acid, and α-alanine. W. prolifica and C. attenuata cultures of all ages released more extracellular protein than total free amino acids. Cultures of C. attenuata released more protein than cultures of the same age of W. prolifica. The filtrates from old cultures of W. prolifica and C. attenuata decreased the total chlorophyll content of all algae tested, totally suppressed conjugation in Spirogyra decimino and zoospore formation in C. attenuata, and drastically decreased spore germination in W. prolifica, thus producing stressful conditions affecting the growth and reproduction of these and other algae.

Solid Phase Synthesis of Novel Fullerene Nucleotides Conjugates

2011 ◽  
Vol 266 ◽  
pp. 200-203
Author(s):  
Jing Zhang ◽  
Ya Dong Zhang
Keyword(s):  
Aspartic Acid ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Biological Properties ◽  
Azomethine Ylide ◽  
Hydroxyl Group ◽  
Spectrometric Analysis ◽  
Phase Synthesis ◽  
Chemical Structures ◽  
Controlled Pore Glass

N-substituted 3, 4-fullero pyrrolidine was synthesized according to 1, 3-dipolar cycloaddition of the azomethine ylide. Aspartic acid with protected α-amino and α-carboxyl groups was reacted with the activated hydroxyl group of N-substituted 3, 4-fullero pyrrolidine. The products were deprotected, affording the monofullerene aspartic acid (mFas). The conjugate FasT was synthesized by reaction of mFas containing protected amino group with the thymidylic acid derivatived controlled pore glass (CPG) using solid phase synthesis. All of the above fullerene derivatives were characterized by UV–vis, 1H NMR, IR and MS spectrometric analysis, giving the correct spectra with regard to their chemical structure. The chemical structures of fullerene nucleotides conjugate FasT is different from previous reports and may have novel biological properties. Moreover, they are more suitable for applications in biomedical research due to their solubilization in THF and DMSO. They have a potential to be used as monomer for the automatic synthesis. It allows further conjugation with specific biomolecules including amino acids, peptides, nucleotides and nucleic acids. A novel method has been developed to synthesize fullerene nucleotides conjugate. Their unique chemical structures make them very interesting for their potential use in medicine and biology.

Contribution of the C30/C75 disulfide bond to the biological properties of onconase

2008 ◽  
Vol 0 (ja) ◽  
pp. 080808065103147-30
Author(s):  
Gerard Torrent ◽  
Antoni Benito ◽  
Jessica Castro ◽  
Marc Ribó ◽  
Maria Vilanova
Keyword(s):  
Disulfide Bond ◽  
Biological Properties

scholarly journals Biosynthesis of .BETA.-(isoxazolin-5-on-2-yl) alanine, the precursor of the neurotoxic amino acid .BETA.-N-oxalyl-L-.ALPHA.,.BETA.-diaminopropionic acid.

1991 ◽  
Vol 39 (12) ◽  
pp. 3376-3377 ◽  
Author(s):  
Fumio IKEGAMI ◽  
Satoshi ITAKAGI ◽  
Tsutomu ISHIKAWA ◽  
Godelieve ONGENA ◽  
Yu-Haey KUO ◽  
...  
Keyword(s):  
Amino Acid ◽  
Alpha Beta ◽  
Diaminopropionic Acid
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