[3-(1,4-Cyclohexadienyl)-L-alanine,8-lysine]vasopressin synthesis and some pharmacological properties

1979 ◽  
Vol 22 (12) ◽  
pp. 1487-1492 ◽  
Author(s):  
Some Nath Banerjee ◽  
Lillian Diamond ◽  
Charlotte Ressler ◽  
Wilbur H. Sawyer
Keyword(s):  
Pharmacological Properties ◽  
Lysine Vasopressin ◽  
Vasopressin Synthesis

4-Phenylalanine analogues of vasopressin: Synthesis, pharmacological and chiroptical properties

1986 ◽  
Vol 51 (7) ◽  
pp. 1532-1541 ◽  
Author(s):  
František Brtník ◽  
Tomislav Barth ◽  
Petr Maloň ◽  
Ivo Frič ◽  
Vija E. Kluša ◽  
...  
Keyword(s):  
Arginine Vasopressin ◽  
Pharmacological Properties ◽  
Cd Spectra ◽  
Chiroptical Properties ◽  
Lysine Vasopressin ◽  
Vasopressin Synthesis

Synthesis, some pharmacological properties and CD spectra of [4-phenylalanine, 8-arginine]vasopressin and [4-phenylalanine, 8-lysine]vasopressin are described.

Synthesis and some pharmacological properties of [7-glycine, 8-ornithine]vasopressin and two of its analogues

1980 ◽  
Vol 45 (10) ◽  
pp. 2865-2871 ◽  
Author(s):  
Michal Lebl ◽  
Tomislav Barth ◽  
Jana Škopková ◽  
Karel Jošt
Keyword(s):  
Liquid Ammonia ◽  
Oxidative Cyclization ◽  
Protecting Groups ◽  
Pharmacological Properties ◽  
Lysine Vasopressin ◽  
Fragment Condensation ◽  
Depressor Effect ◽  
Protected Peptides

Protected peptides were prepared by fragment condensation according to the scheme 6 + 3 or 9 + 3, which, after the removal of the protecting groups by sodium in liquid ammonia and oxidative cyclization, afforded [7-glycine,8-ornithine]vasopressin, [7-glycine,8-ornithine]deaminovasopressin, and Nα-glycyl-glycyl-glycyl[7-glycine,8-ornithine]vasopressin. All the analogues had very low intrinsic vasopressin-like activities; the analogue with hormonogen nature had a depressor effect and inhibited the pressor action of lysine-vasopressin.

[7-Glycine]deamino-1-carba-vasopressin: Synthesis and pharmacological properties

1981 ◽  
Vol 46 (1) ◽  
pp. 278-285 ◽  
Author(s):  
František Brtník ◽  
Tomislav Barth ◽  
Karel Jošt
Keyword(s):  
Substantial Decrease ◽  
Pharmacological Properties ◽  
Amino Terminal ◽  
Glycine Derivative ◽  
Carboxy Terminal ◽  
Cyclic Part ◽  
Vasopressin Synthesis

[8-Arginine]deamino-1-carba-vasopressin and its 7-glycine derivative were prepared by condensation of the amino-terminal, cyclic part of the molecule with carboxy-terminal tripeptide amides. Replacement of proline by glycine in the position 7 results in a substantial decrease in the vasopressin-like activities, the oxytocin-like activities remaining unchanged.

Sign in / Sign up

Export Citation Format

Share Document