Synthesis and biological activity of an acyclic analog of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]amino]benzoyl]-L-glutamic acid [Erratum to document cited in CA112(7):56616d]

1990 ◽  
Vol 33 (11) ◽  
pp. 3116-3116
Author(s):  
James L. Kelley ◽  
Ed W. McLean ◽  
Naomi K. Cohn ◽  
Mark P. Edelstein ◽  
David S. Duch ◽  
...  
Keyword(s):  
Biological Activity ◽  
Glutamic Acid ◽  
Acyclic Analog ◽  
Tetrahydrofolic Acid

Synthesis and biological activity of an acyclic analog of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]amino]benzoyl]-L-glutamic acid

1990 ◽  
Vol 33 (2) ◽  
pp. 561-567 ◽  
Author(s):  
James L. Kelley ◽  
Ed W. McLean ◽  
Naomi K. Cohn ◽  
Mark P. Edelstein ◽  
David S. Duch ◽  
...  
Keyword(s):  
Biological Activity ◽  
Glutamic Acid ◽  
Acyclic Analog ◽  
Tetrahydrofolic Acid

scholarly journals A correlation study of biological activity and molecular docking of Asp and Glu linked bis-hydrazones of quinazolinones

RSC Advances ◽  
2018 ◽  
Vol 8 (19) ◽  
pp. 10644-10653 ◽  
Author(s):  
H. K. Kumara ◽  
R. Suhas ◽  
D. M. Suyoga Vardhan ◽  
M. Shobha ◽  
D. Channe Gowda
Keyword(s):  
Biological Activity ◽  
Molecular Docking ◽  
Glutamic Acid ◽  
Aspartic Acid ◽  
Correlation Study

The present investigation involves the synthesis and spectroscopic and biological activity studies of the bis-hydrazones of quinazolinones derived from aspartic acid and glutamic acid.

scholarly journals Studies on the response ofLactobacillus caseito different folate monoglutamates

1982 ◽  
Vol 47 (2) ◽  
pp. 183-189 ◽  
Author(s):  
D. R. Phillips ◽  
A. J. A. Wright
Keyword(s):  
Folic Acid ◽  
Glutamic Acid ◽  
Lactobacillus Casei ◽  
Tetrahydrofolic Acid

1. The response ofLactobacillus caseiwas measured for a number of the monoglutamyl forms of folate derivatives.2. At the concentrations of folate commonly used in the assay of folate vitamin in foods the response ofL. caseito folic acid, (pteroyl glutamic acid) and 5-formyl-tetrahydrofolic acid was similar, but 5-methyl-tetrahydrofolic acid gave as little as half the response of folic acid.3. The response was modified by altering pH but not by concentration of ascorbate.4. These results have implications for the assays of foods for folate where mixtures of folate derivatives are present.5. A modified procedure is suggested in which the monoglutamates give similar responses.

scholarly journals Vitamin K-dependent proteins: osteocalcin, matrix Gla-protein and extra osseous effects

2013 ◽  
Vol 10 (2) ◽  
pp. 11-18
Author(s):  
Yu В Pankratova ◽  
E A Pigarova ◽  
L K Dzeranova
Keyword(s):  
Biological Activity ◽  
Connective Tissue ◽  
Literature Review ◽  
Glutamic Acid ◽  
Functional Properties ◽  
Vitamin K ◽  
Blood Clotting ◽  
Matrix Gla Protein ◽  
Human Proteins ◽  
Polypeptide Chains

Vitamin K - is a fat-soluble vitamin which plays an important role in the metabolism of bone and connective tissue, maintenance blood clotting properties. Vitamin K is involved in carboxylation of glutamic acid residues in the polypeptide chains of 14 human proteins, providing them with the necessary functional properties. Lack of vitamin K-dependent carboxylation of these proteins leads to changes in their biological activity. In this literature review we cover the mechanisms of vitamin K-dependent carboxylation and none bone actions of osteocalcin and matrix Gla-protein with different degrees of carboxylation.

Synthesis and biological activity of open-chain analogs of 5,6,7,8-tetrahydrofolic acid-potential antitumor agents

1992 ◽  
Vol 35 (8) ◽  
pp. 1399-1410 ◽  
Author(s):  
Eric C. Bigham ◽  
Stephen J. Hodson ◽  
W. Revill Mallory ◽  
David Wilson ◽  
David S. Duch ◽  
...  
Keyword(s):  
Biological Activity ◽  
Antitumor Agents ◽  
Open Chain ◽  
Tetrahydrofolic Acid ◽  
Acid Potential ◽  
Potential Antitumor
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