Benzophenone dicarboxylic acid antagonists of leukotriene B4. 1. Structure-activity relationships of the benzophenone nucleus

D. Mark Gapinski; Barbara E. Mallett; Larry L. Froelich; William T. Jackson

doi:10.1021/jm00172a019

Benzophenone dicarboxylic acid antagonists of leukotriene B4. 1. Structure-activity relationships of the benzophenone nucleus

Journal of Medicinal Chemistry ◽

10.1021/jm00172a019 ◽

1990 ◽

Vol 33 (10) ◽

pp. 2798-2807 ◽

Cited By ~ 18

Author(s):

D. Mark Gapinski ◽

Barbara E. Mallett ◽

Larry L. Froelich ◽

William T. Jackson

Keyword(s):

Dicarboxylic Acid ◽

Leukotriene B4 ◽

Structure Activity Relationships ◽

Structure Activity

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Benzophenone dicarboxylic acid antagonists of leukotriene B4. 2. Structure-activity relationships of the lipophilic side chain

Journal of Medicinal Chemistry ◽

10.1021/jm00172a020 ◽

1990 ◽

Vol 33 (10) ◽

pp. 2807-2813 ◽

Cited By ~ 20

Author(s):

D. Mark Gapinski ◽

Barbara E. Mallett ◽

Larry L. Froelich ◽

William T. Jackson

Keyword(s):

Dicarboxylic Acid ◽

Leukotriene B4 ◽

Side Chain ◽

Structure Activity Relationships ◽

Structure Activity

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Synthesis, in Vitro Pharmacology, Structure−Activity Relationships, and Pharmacokinetics of 3-Alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Derivatives as Potent and Selective Group II Metabotropic Glutamate Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm0400294 ◽

2004 ◽

Vol 47 (18) ◽

pp. 4570-4587 ◽

Cited By ~ 41

Author(s):

Atsuro Nakazato ◽

Kazunari Sakagami ◽

Akito Yasuhara ◽

Hiroshi Ohta ◽

Ryoko Yoshikawa ◽

...

Keyword(s):

Dicarboxylic Acid ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Metabotropic Glutamate ◽

Structure Activity ◽

Glutamate Receptor Antagonists ◽

In Vitro Pharmacology

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2,4-Dicarboxy-pyrroles as Selective Non-Competitive mGluR1 Antagonists: Further Characterization of 3,5-Dimethyl Pyrrole-2,4-dicarboxylic Acid 2-Propyl Ester 4-(1,2,2-Trimethyl-propyl) Ester and Structure—Activity Relationships.

ChemInform ◽

10.1002/chin.200342113 ◽

2003 ◽

Vol 34 (42) ◽

Author(s):

Fabrizio Micheli ◽

Romano Di Fabio ◽

et al. et al.

Keyword(s):

Dicarboxylic Acid ◽

Structure Activity Relationships ◽

Propyl Ester ◽

Structure Activity

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ChemInform Abstract: Structure-Activity Relationships Study of Two Series of Leukotriene B4 Antagonists: Novel Indolyl and Naphthyl Compounds Substituted with a 2- (Methyl(2-phenethyl)amino)-2-oxoethyl Side Chain.

ChemInform ◽

10.1002/chin.199704109 ◽

2010 ◽

Vol 28 (4) ◽

pp. no-no

Author(s):

W. K. CHAN ◽

F.-C. HUANG ◽

M. M. MORRISSETTE ◽

J. D. WARUS ◽

K. J. MORIARTY ◽

...

Keyword(s):

Leukotriene B4 ◽

Side Chain ◽

Structure Activity Relationships ◽

Structure Activity ◽

Abstract Structure

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Structure-activity relationships among derivatives of dicarboxylic acid esters of tropine

Pharmacology & Therapeutics ◽

10.1016/s0163-7258(02)00296-6 ◽

2002 ◽

Vol 96 (1) ◽

pp. 1-21 ◽

Cited By ~ 8

Author(s):

L Gyermek

Keyword(s):

Dicarboxylic Acid ◽

Structure Activity Relationships ◽

Structure Activity ◽

Derivatives Of ◽

Acid Esters

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ChemInform Abstract: Trisubstituted Pyridine Leukotriene B4 Receptor Antagonists: Synthesis and Structure-Activity Relationships.

ChemInform ◽

10.1002/chin.199411153 ◽

2010 ◽

Vol 25 (11) ◽

pp. no-no

Author(s):

R. A. DAINES ◽

P. A. CHAMBERS ◽

I. PENDRAK ◽

D. R. JAKAS ◽

H. M. SARAU ◽

...

Keyword(s):

Leukotriene B4 ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Leukotriene B4 Receptor

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Trisubstituted benzene leukotriene B4 receptor antagonists: Synthesis and structure-activity relationships

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(97)00089-8 ◽

1997 ◽

Vol 5 (8) ◽

pp. 1649-1674 ◽

Cited By ~ 3

Author(s):

Mitoshi Konno ◽

Takahiko Nakae ◽

Shigeru Sakuyama ◽

Yoshihiko Odagaki ◽

Hisao Nakai ◽

...

Keyword(s):

Leukotriene B4 ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Leukotriene B4 Receptor

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Novel inhibitors of prolyl 4-hydroxylase. 5. The intriguing structure-activity relationships seen with 2,2'-bipyridine and its 5,5'-dicarboxylic acid derivatives

Journal of Medicinal Chemistry ◽

10.1021/jm00076a014 ◽

1993 ◽

Vol 36 (24) ◽

pp. 3853-3858 ◽

Cited By ~ 25

Author(s):

Neil J. Hales ◽

John F. Beattie

Keyword(s):

Dicarboxylic Acid ◽

Structure Activity Relationships ◽

Structure Activity

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2,4-Dicarboxy-pyrroles as selective non-Competitive mGluR1 antagonists: further characterization of 3,5-Dimethyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-Trimethyl-propyl) ester and structure–Activity relationships

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(03)00396-2 ◽

2003 ◽

Vol 13 (13) ◽

pp. 2113-2118 ◽

Cited By ~ 21

Author(s):

Fabrizio Micheli ◽

Romano Di Fabio ◽

Fabio Bordi ◽

Palmina Cavallini ◽

Paolo Cavanni ◽

...

Keyword(s):

Dicarboxylic Acid ◽

Structure Activity Relationships ◽

Propyl Ester ◽

Structure Activity

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Synthesis, in vitro pharmacology, and structure–activity relationships of 2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as mGluR2 antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2005.12.061 ◽

2006 ◽

Vol 14 (10) ◽

pp. 3405-3420 ◽

Cited By ~ 12

Author(s):

Akito Yasuhara ◽

Kazunari Sakagami ◽

Ryoko Yoshikawa ◽

Shigeyuki Chaki ◽

Masato Nakamura ◽

...

Keyword(s):

Dicarboxylic Acid ◽

Structure Activity Relationships ◽

Structure Activity ◽

In Vitro Pharmacology

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