Inhibitors of cholesterol biosynthesis. 1. trans-6-(2-Pyrrol-1-ylethyl)-4-hydroxypyran-2-ones, a novel series of HMG-CoA reductase inhibitors. 1. Effects of structural modifications at the 2- and 5-positions of the pyrrole nucleus

Bruce D. Roth; D. F. Ortwine; M. L. Hoefle; C. D. Stratton; D. R. Sliskovic; M. W. Wilson; R. S. Newton

doi:10.1021/jm00163a005

Inhibitors of cholesterol biosynthesis. 1. trans-6-(2-Pyrrol-1-ylethyl)-4-hydroxypyran-2-ones, a novel series of HMG-CoA reductase inhibitors. 1. Effects of structural modifications at the 2- and 5-positions of the pyrrole nucleus

Journal of Medicinal Chemistry ◽

10.1021/jm00163a005 ◽

1990 ◽

Vol 33 (1) ◽

pp. 21-31 ◽

Cited By ~ 44

Author(s):

Bruce D. Roth ◽

D. F. Ortwine ◽

M. L. Hoefle ◽

C. D. Stratton ◽

D. R. Sliskovic ◽

...

Keyword(s):

Cholesterol Biosynthesis ◽

Hmg Coa Reductase ◽

Structural Modifications ◽

Reductase Inhibitors ◽

Hmg Coa Reductase Inhibitors ◽

Coa Reductase

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ChemInform Abstract: Inhibitors of Cholesterol Biosynthesis. Part 1. trans-6-(2-Pyrrol-1-ylethyl)-4-hydroxypyran-2-ones, a Novel Series of HMG-CoA Reductase Inhibitors. Part 1. Effects of Structural Modifications at the 2- and 5-Positions of the Pyrrole N

ChemInform ◽

10.1002/chin.199022161 ◽

1990 ◽

Vol 21 (22) ◽

Author(s):

B. D. ROTH ◽

D. F. ORTWINE ◽

M. L. HOEFLE ◽

C. D. STRATTON ◽

D. R. SLISKOVIC ◽

...

Keyword(s):

Cholesterol Biosynthesis ◽

Hmg Coa Reductase ◽

Structural Modifications ◽

Reductase Inhibitors ◽

Hmg Coa Reductase Inhibitors ◽

Coa Reductase

Download Full-text

ChemInform Abstract: Inhibitors of Cholesterol Biosynthesis. Part 2. 3,5-Dihydroxy-7-(N- pyrrolyl)-6-heptenoates, a Novel Series of HMG-CoA Reductase Inhibitors.

ChemInform ◽

10.1002/chin.199413162 ◽

2010 ◽

Vol 25 (13) ◽

pp. no-no

Author(s):

P. A. PROCOPIOU ◽

C. D. DRAPER ◽

J. L. HUTSON ◽

G. G. A. INGLIS ◽

B. C. ROSS ◽

...

Keyword(s):

Cholesterol Biosynthesis ◽

Hmg Coa Reductase ◽

Reductase Inhibitors ◽

Hmg Coa Reductase Inhibitors ◽

Coa Reductase

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ChemInform Abstract: Inhibitors of Cholesterol Biosynthesis. Part 4. trans-6-(2-( Substituted-quinolinyl)ethenyl/ethyl)tetrahydro-4-hydroxy-2H-pyran-2- ones, a Novel Series of HMG-CoA Reductase Inhibitors.

ChemInform ◽

10.1002/chin.199124162 ◽

2010 ◽

Vol 22 (24) ◽

pp. no-no

Author(s):

D. R. SLISKOVIC ◽

J. A. PICARD ◽

W. H. ROARK ◽

B. D. ROTH ◽

E. FERGUSON ◽

...

Keyword(s):

Cholesterol Biosynthesis ◽

Hmg Coa Reductase ◽

Reductase Inhibitors ◽

Hmg Coa Reductase Inhibitors ◽

Coa Reductase

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ChemInform Abstract: Inhibitors of Cholesterol Biosynthesis. Part 1. 3,5-Dihydroxy-7-(N- imidazolyl)-6-heptenoates and -heptanoates, a Novel Series of HMG-CoA Reductase Inhibitors.

ChemInform ◽

10.1002/chin.199413171 ◽

2010 ◽

Vol 25 (13) ◽

pp. no-no

Author(s):

C. CHAN ◽

E. J. BAILEY ◽

C. D. HARTLEY ◽

D. F. HAYMAN ◽

J. L. HUTSON ◽

...

Keyword(s):

Cholesterol Biosynthesis ◽

Hmg Coa Reductase ◽

Reductase Inhibitors ◽

Hmg Coa Reductase Inhibitors ◽

Coa Reductase

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Inhibitors of cholesterol biosynthesis. 2. 3,5-Dihydroxy-7-(N-pyrrolyl)-6-heptenoates, a novel series of HMG-CoA reductase inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm00075a021 ◽

1993 ◽

Vol 36 (23) ◽

pp. 3658-3662 ◽

Cited By ~ 18

Author(s):

Panayiotis A. Procopiou ◽

Christopher D. Draper ◽

Julie L. Hutson ◽

Graham G. A. Inglis ◽

Barry C. Ross ◽

...

Keyword(s):

Cholesterol Biosynthesis ◽

Hmg Coa Reductase ◽

Reductase Inhibitors ◽

Hmg Coa Reductase Inhibitors ◽

Coa Reductase

Download Full-text

Inhibitors of cholesterol biosynthesis. 4. trans-6-[2-(Substituted-quinolinyl)ethenyl/ethyl]tetrahydro-4-hydroxy-2H-pyran-2-ones, a novel series of HMG-CoA reductase inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm00105a057 ◽

1991 ◽

Vol 34 (1) ◽

pp. 367-373 ◽

Cited By ~ 35

Author(s):

D. R. Sliskovic ◽

J. A. Picard ◽

W. H. Roark ◽

B. D. Roth ◽

E. Ferguson ◽

...

Keyword(s):

Cholesterol Biosynthesis ◽

Hmg Coa Reductase ◽

Reductase Inhibitors ◽

Hmg Coa Reductase Inhibitors ◽

Coa Reductase

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Use of HMG-CoA Reductase Inhibitors Is Associated With Lower Plasma Interleukin-6 Levels and a Favourable Cardiac Course in Unstable Angina

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(97)85097-8 ◽

1998 ◽

Vol 31 (2) ◽

pp. 318A

Author(s):

P Verheggen

Keyword(s):

Unstable Angina ◽

Interleukin 6 ◽

Lower Plasma ◽

Hmg Coa Reductase ◽

Reductase Inhibitors ◽

Hmg Coa Reductase Inhibitors ◽

Coa Reductase

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Similarity of molecular electrostatic potential distributions in a series of HMG-CoA reductase inhibitors. Preliminary results

Journal de Chimie Physique ◽

10.1051/jcp/1991882639 ◽

1991 ◽

Vol 88 ◽

pp. 2639-2644 ◽

Cited By ~ 1

Author(s):

U Cosentino ◽

G Moro ◽

D Pitea

Keyword(s):

Electrostatic Potential ◽

Molecular Electrostatic Potential ◽

Hmg Coa Reductase ◽

Preliminary Results ◽

Reductase Inhibitors ◽

Hmg Coa Reductase Inhibitors ◽

Coa Reductase

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Preventing Levodopa Induced Dyskinesia in Parkinson's Disease With HMG-CoA Reductase Inhibitors

Case Medical Research ◽

10.31525/ct1-nct04064294 ◽

2019 ◽

Author(s):

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Hmg Coa Reductase ◽

Reductase Inhibitors ◽

Hmg Coa Reductase Inhibitors ◽

Coa Reductase

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Faculty Opinions recommendation of HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718557304.793500018 ◽

2014 ◽

Author(s):

Luis Ruilope ◽

Enrique Morales

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Hmg Coa Reductase ◽

Reductase Inhibitors ◽

Hmg Coa Reductase Inhibitors ◽

Coa Reductase

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