Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types

Sylvester Klutchko; C. John Blankley; Robert W. Fleming; Jack M. Hinkley; Ann E. Werner; Ivan Nordin; Ann Holmes; Milton L. Hoefle; David M. Cohen

doi:10.1021/jm00160a026

Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types

Journal of Medicinal Chemistry ◽

10.1021/jm00160a026 ◽

1986 ◽

Vol 29 (10) ◽

pp. 1953-1961 ◽

Cited By ~ 67

Author(s):

Sylvester Klutchko ◽

C. John Blankley ◽

Robert W. Fleming ◽

Jack M. Hinkley ◽

Ann E. Werner ◽

...

Keyword(s):

Angiotensin Converting Enzyme ◽

Angiotensin Converting Enzyme Inhibitor ◽

Enzyme Inhibitor ◽

Converting Enzyme ◽

Converting Enzyme Inhibitor ◽

Structure Activity Relationships ◽

Structure Activity ◽

Related Compounds

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ChemInform Abstract: Synthesis of Novel Angiotensin Converting Enzyme Inhibitor Quinapril and Related Compounds. A Divergence of Structure-Activity Relationships for Non-Sulfhydryl and Sulfhydryl Types.

ChemInform ◽

10.1002/chin.198711185 ◽

1987 ◽

Vol 18 (11) ◽

Author(s):

S. KLUTCHKO ◽

C. J. BLANKLEY ◽

R. W. FLEMING ◽

J. M. HINKLEY ◽

A. E. WERNER ◽

...

Keyword(s):

Angiotensin Converting Enzyme ◽

Angiotensin Converting Enzyme Inhibitor ◽

Enzyme Inhibitor ◽

Converting Enzyme ◽

Converting Enzyme Inhibitor ◽

Structure Activity Relationships ◽

Structure Activity ◽

Related Compounds

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Structure-activity relationships study of angiotensin-converting enzyme inhibitor captopril derivatives

Journal of Molecular Graphics ◽

10.1016/0263-7855(93)80062-v ◽

1993 ◽

Vol 11 (4) ◽

pp. 283

Author(s):

C.N. Yoon

Keyword(s):

Angiotensin Converting Enzyme ◽

Angiotensin Converting Enzyme Inhibitor ◽

Enzyme Inhibitor ◽

Converting Enzyme ◽

Converting Enzyme Inhibitor ◽

Structure Activity Relationships ◽

Structure Activity

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Angiotensin-Converting Enzyme Inhibitor-Associated Angioedema

Allergy & Clinical Immunology International - Journal of the World Allergy Organization ◽

10.1027/0838-1925.19.4.164 ◽

2007 ◽

Vol 19 (4) ◽

pp. 164-165

Author(s):

Byol Shin ◽

Richard Lockey

Keyword(s):

Angiotensin Converting Enzyme ◽

Angiotensin Converting Enzyme Inhibitor ◽

Enzyme Inhibitor ◽

Converting Enzyme ◽

Converting Enzyme Inhibitor

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AT1-Receptorblocker Versus Angiotensin Converting Enzyme Inhibitor in Acute Myocardial Infarction? Role of Dosage and Bradykinin on Remodeling, Hemodynamics and Mortality in the Rat Model

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(97)85064-4 ◽

1998 ◽

Vol 31 (2) ◽

pp. 311A

Author(s):

P Gaudron

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Angiotensin Converting Enzyme ◽

Angiotensin Converting Enzyme Inhibitor ◽

Rat Model ◽

Enzyme Inhibitor ◽

Converting Enzyme ◽

Converting Enzyme Inhibitor

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Faculty Opinions recommendation of Chronic angiotensin-converting enzyme inhibitor or angiotensin receptor blocker therapy combined with diuretic therapy is associated with increased episodes of hypotension in noncardiac surgery.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1108262.565200 ◽

2008 ◽

Author(s):

Nikolaus Gravenstein ◽

Felipe Urdaneta

Keyword(s):

Angiotensin Converting Enzyme ◽

Angiotensin Converting Enzyme Inhibitor ◽

Angiotensin Receptor Blocker ◽

Enzyme Inhibitor ◽

Diuretic Therapy ◽

Noncardiac Surgery ◽

Converting Enzyme ◽

Angiotensin Receptor ◽

Blocker Therapy ◽

Converting Enzyme Inhibitor

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Faculty Opinions recommendation of Chronic angiotensin-converting enzyme inhibitor or angiotensin receptor blocker therapy combined with diuretic therapy is associated with increased episodes of hypotension in noncardiac surgery.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1108262.564286 ◽

2008 ◽

Author(s):

John Augoustides

Keyword(s):

Angiotensin Converting Enzyme ◽

Angiotensin Converting Enzyme Inhibitor ◽

Angiotensin Receptor Blocker ◽

Enzyme Inhibitor ◽

Diuretic Therapy ◽

Noncardiac Surgery ◽

Converting Enzyme ◽

Angiotensin Receptor ◽

Blocker Therapy ◽

Converting Enzyme Inhibitor

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Faculty Opinions recommendation of Effects on insulin action of adding low-dose thiazide to angiotensin-converting enzyme inhibitor in essential hypertension.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717985483.793473970 ◽

2013 ◽

Author(s):

Bo Carlberg ◽

Mattias Brunström

Keyword(s):

Essential Hypertension ◽

Angiotensin Converting Enzyme ◽

Angiotensin Converting Enzyme Inhibitor ◽

Insulin Action ◽

Low Dose ◽

Enzyme Inhibitor ◽

Converting Enzyme ◽

Converting Enzyme Inhibitor

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Faculty Opinions recommendation of Influence of race and dietary salt on the antihypertensive efficacy of an angiotensin-converting enzyme inhibitor or a calcium channel antagonist in salt-sensitive hypertensives.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725125555.793502388 ◽

2014 ◽

Author(s):

Athanasios Manolis

Keyword(s):

Angiotensin Converting Enzyme ◽

Calcium Channel ◽

Angiotensin Converting Enzyme Inhibitor ◽

Calcium Channel Antagonist ◽

Enzyme Inhibitor ◽

Antihypertensive Efficacy ◽

Converting Enzyme ◽

Dietary Salt ◽

Converting Enzyme Inhibitor

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Faculty Opinions recommendation of Ordering of the Serum Angiotensin-Converting Enzyme Test in Patients Receiving Angiotensin-Converting Enzyme Inhibitor Therapy: An Avoidable but Common Error.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725687474.793513300 ◽

2016 ◽

Author(s):

Lars C Huber

Keyword(s):

Angiotensin Converting Enzyme ◽

Angiotensin Converting Enzyme Inhibitor ◽

Enzyme Inhibitor ◽

Inhibitor Therapy ◽

Converting Enzyme ◽

Common Error ◽

Serum Angiotensin Converting Enzyme ◽

Converting Enzyme Inhibitor ◽

Enzyme Test

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Anticipated combination of beta-blocker and angiotensin-converting enzyme inhibitor: new opportunities for optimizing treatment of cardiovascular patients

HYPERTENSION ◽

10.22141/2224-1485.4.54.2017.109540 ◽

2017 ◽

Vol 0 (4.54) ◽

pp. 9-17

Author(s):

Yu.M. Sirenko ◽

O.O. Torbas

Keyword(s):

Angiotensin Converting Enzyme ◽

Angiotensin Converting Enzyme Inhibitor ◽

Beta Blocker ◽

Enzyme Inhibitor ◽

Converting Enzyme ◽

Converting Enzyme Inhibitor ◽

Cardiovascular Patients

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