Systematic synthesis and biological evaluation of .alpha.- and .beta.-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogs

1986 ◽  
Vol 29 (2) ◽  
pp. 203-213 ◽  
Author(s):  
Gilles Gosselin ◽  
Marie Christine Bergogne ◽  
Jean De Rudder ◽  
Erik De Clercq ◽  
Jean Louis Imbach
Keyword(s):  
Nucleic Acids ◽  
Biological Evaluation ◽  
Naturally Occurring ◽  
Synthesis And Biological Evaluation ◽  
Systematic Synthesis

Synthesis and Biological Evaluation of Isomeric Derivatives of Naturally Occurring Spatozoate.

ChemInform ◽  
2006 ◽  
Vol 37 (38) ◽  
Author(s):  
Safdar Hayat ◽  
Atta-ur-Rahman Atta-ur-Rahman ◽  
Muhammad Iqbal Choudhary ◽  
Khalid Mohammed Khan ◽  
Shahnaz Perveen ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Naturally Occurring ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of

scholarly journals Marine Terpenoid Diacylguanidines: Structure, Synthesis, and Biological Evaluation of Naturally Occurring Actinofide and Synthetic Analogues

2017 ◽  
Vol 80 (5) ◽  
pp. 1339-1346 ◽  
Author(s):  
Marianna Carbone ◽  
M. Letizia Ciavatta ◽  
Véronique Mathieu ◽  
Aude Ingels ◽  
Robert Kiss ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Synthetic Analogues ◽  
Naturally Occurring ◽  
Structure Synthesis ◽  
Synthesis And Biological Evaluation

Synthesis and biological evaluation of pharbinilic acid and derivatives as NF-κB pathway inhibitors

2015 ◽  
Vol 51 (43) ◽  
pp. 8990-8993 ◽  
Author(s):  
J. R. Annand ◽  
P. A. Bruno ◽  
A. K. Mapp ◽  
C. S. Schindler
Keyword(s):  
Natural Products ◽  
Biological Evaluation ◽  
Naturally Occurring ◽  
Synthesis And Biological Evaluation

A 7-step synthesis of pharbinilic acid, a member of the gibberellin family of natural products and the first naturally occurring allogibberic acid, is reported.

Heterocyclic analogs of nucleosides: synthesis and biological evaluation of novel analogs of puromycin

1994 ◽  
Vol 72 (9) ◽  
pp. 1978-1989 ◽  
Author(s):  
Philip G. Hultin ◽  
Walter A. Szarek
Keyword(s):  
Nuclear Magnetic Resonance ◽  
High Pressure ◽  
Liquid Chromatography ◽  
Biological Evaluation ◽  
Nuclear Magnetic Resonance Analysis ◽  
Resonance Analysis ◽  
Naturally Occurring ◽  
Synthesis And Biological Evaluation ◽  
Anti Hiv

The diastereomeric 1-(piperidin-3′-yl)uracil compounds 20a, b, and the N6-dimethyl-9-(piperidin-3′-yl)adenine compounds 21a, b, have been prepared as analogs of the naturally occurring aminoacyl nucleoside antibiotic puromycin. The diastereomers were separated using high-pressure liquid chromatography, and the absolute configuration of the more mobile diastereomer 20a was assigned as (3′S,5′R) by 1H and 13C nuclear magnetic resonance analysis, and by molecular modelling. Therefore, the less mobile diastereomer 20b had the (3′R,5′S) configuration. The configurations of 21a and 21b were assigned by analogy with 20a and 20b. These puromycin analogs have been tested for anti-HIV and antitumor activity in vitro.

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