Synthesis and in vivo photodynamic activity of some bacteriochlorin derivatives against bladder tumors in rodents

1991 ◽  
Vol 34 (7) ◽  
pp. 2126-2133 ◽  
Author(s):  
Alan R. Morgan ◽  
Greta M. Garbo ◽  
Rick W. Keck ◽  
Steven H. Selman ◽  
Dimitris Skalkos
Keyword(s):  
Bladder Tumors ◽  
Photodynamic Activity

The photodynamic activity and toxicity evaluation of 5,10,15-tris(ethoxylcarbonyl)corrole phosphorus(V) in vivo and in vitro

2019 ◽  
Vol 163 ◽  
pp. 779-786 ◽  
Author(s):  
Zhao Zhang ◽  
Hua-Jun Yu ◽  
Hui Huang ◽  
Hua-Hua Wang ◽  
Shang Wu ◽  
...  
Keyword(s):  
Toxicity Evaluation ◽  
Photodynamic Activity

scholarly journals In vivo fluorescence and photodynamic activity of zinc phthalocyanine administered in liposomes

1994 ◽  
Vol 69 (5) ◽  
pp. 840-845 ◽  
Author(s):  
HLLM van Leengoed ◽  
V Cuomo ◽  
AAC Versteeg ◽  
N van der Veen ◽  
G Jori ◽  
...  
Keyword(s):  
Zinc Phthalocyanine ◽  
In Vivo Fluorescence ◽  
Photodynamic Activity

scholarly journals Conjugation of 2-(1′-Hexyloxyethyl)-2-devinylpyropheophorbide-a (HPPH) to Carbohydrates Changes its Subcellular Distribution and Enhances Photodynamic Activity in Vivo†

2009 ◽  
Vol 52 (14) ◽  
pp. 4306-4318 ◽  
Author(s):  
Xiang Zheng ◽  
Janet Morgan ◽  
Suresh K. Pandey ◽  
Yihui Chen ◽  
Erin Tracy ◽  
...  
Keyword(s):  
Subcellular Distribution ◽  
Photodynamic Activity

scholarly journals Photoactivatable Metabolic Warheads Enable Precise and Safe Ablation of Target Cells in Vivo

2020 ◽  
Author(s):  
Sam Benson ◽  
Fabio de Moliner ◽  
Antonio Fernandez ◽  
Erkin Kuru ◽  
Nicholas Asiimwe ◽  
...  
Keyword(s):  
Side Effects ◽  
Bacterial Infections ◽  
Disease Onset ◽  
Surgical Approaches ◽  
Target Cells ◽  
Malignant Cells ◽  
Photodynamic Activity ◽  
Chemical Groups ◽  
Synthetic Derivatives

Photoactivatable molecules enable ablation of malignant cells under the control of light, yet current agents can be ineffective at early stages of disease when target cells are similar to healthy surrounding tissues. In this work, we describe a chemical platform based on amino-substituted benzoselenadiazoles to build photosensitizers that mimic native metabolites as indicators of disease onset and progression. Through a series of synthetic derivatives, we have identified the key chemical groups in the benzoselenadiazole scaffold responsible for its photodynamic activity, and subsequently designed photosensitive metabolic warheads to target cells associated with various diseases, including bacterial infections and cancer. We demonstrate that versatile benzoselenadiazole metabolites can selectively kill pathogenic cells -but not healthy cells- with high precision after exposure to non-toxic visible light, reducing any potential side effects in vivo. This chemical platform provides powerful new tools to exploit cellular metabolic signatures for safer therapeutic and surgical approaches. <br>

In Vivo Cytotoxicity of Metallopurpurins to Bladder Tumors

1988 ◽  
pp. 495-497 ◽  
Author(s):  
A. R. Morgan ◽  
G. M. Garbo ◽  
R. W. Keck ◽  
S. H. Selman
Keyword(s):  
Bladder Tumors ◽  
In Vivo Cytotoxicity

OBSERVATIONS ON THE SYNTHESIS AND in vivo PHOTODYNAMIC ACTIVITY OF SOME BENZOCHLORINS

1992 ◽  
Vol 55 (1) ◽  
pp. 133-136 ◽  
Author(s):  
Alan R. Morgan ◽  
Dimitris Skalkos ◽  
George Maguire ◽  
Ashraf Rampersaud ◽  
Greta Garbo ◽  
...  
Keyword(s):  
Photodynamic Activity

Improved photodynamic activity of porphyrin loaded into nanoparticles: an in vivo evaluation using chick embryos

2004 ◽  
Vol 286 (1-2) ◽  
pp. 131-145 ◽  
Author(s):  
Angelica Vargas ◽  
Bernadette Pegaz ◽  
Elodie Debefve ◽  
Yvette Konan-Kouakou ◽  
Norbert Lange ◽  
...  
Keyword(s):  
Chick Embryos ◽  
In Vivo Evaluation ◽  
Photodynamic Activity
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