Nonpeptide angiotensin II receptor antagonists: synthetic and computational chemistry of N-[[4-[2-(2H-tetrazol-5-yl)-1-cycloalken-1-yl]phenyl]methyl]imidazole derivatives and their in vitro activity

Ho Shen Lin; Ashraff A. Rampersaud; Karen Zimmerman; Mitchell I. Steinberg; Donald B. Boyd

doi:10.1021/jm00092a017

Nonpeptide angiotensin II receptor antagonists: synthetic and computational chemistry of N-[[4-[2-(2H-tetrazol-5-yl)-1-cycloalken-1-yl]phenyl]methyl]imidazole derivatives and their in vitro activity

Journal of Medicinal Chemistry ◽

10.1021/jm00092a017 ◽

1992 ◽

Vol 35 (14) ◽

pp. 2658-2667 ◽

Cited By ~ 27

Author(s):

Ho Shen Lin ◽

Ashraff A. Rampersaud ◽

Karen Zimmerman ◽

Mitchell I. Steinberg ◽

Donald B. Boyd

Keyword(s):

Angiotensin Ii ◽

Computational Chemistry ◽

Vitro Activity ◽

In Vitro Activity ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Imidazole Derivatives ◽

Methyl Imidazole

Download Full-text

Nonpeptide angiotensin II receptor antagonists. 1. Synthesis and in vitro structure-activity relationships of 4-[[[(1H-pyrrol-1-ylacetyl)amino]phenyl]methyl]imidazole derivatives as angiotensin II receptor antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm00064a007 ◽

1993 ◽

Vol 36 (12) ◽

pp. 1735-1745 ◽

Cited By ~ 12

Author(s):

Ila Sircar ◽

R. Thomas Winters ◽

John Quin ◽

Gina H. Lu ◽

Terry C. Major ◽

...

Keyword(s):

Angiotensin Ii ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Imidazole Derivatives ◽

Structure Activity ◽

Methyl Imidazole

Download Full-text

Nonpeptide Angiotensin II Receptor Antagonists. Synthesis, in vitro Activity, and Molecular Modeling Studies of N-[(Heterobiaryl)methyl]imidazoles

Journal of Medicinal Chemistry ◽

10.1021/jm00049a012 ◽

1994 ◽

Vol 37 (23) ◽

pp. 3928-3938 ◽

Cited By ~ 14

Author(s):

Aldo Salimbeni ◽

Renato Canevotti ◽

Fabio Paleari ◽

Fabrizio Bonaccorsi ◽

Anna R. Renzetti ◽

...

Keyword(s):

Molecular Modeling ◽

Angiotensin Ii ◽

Vitro Activity ◽

In Vitro Activity ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Modeling Studies ◽

Molecular Modeling Studies

Download Full-text

Nonpeptide angiotensin II receptor antagonists. 2. Design, synthesis, and structure-activity relationships of 2-alkyl-4-(1H-pyrrol-l-yl)-1H-imidazole derivatives: profile of 2-propyl-1-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-4-[2-(trifluoroacetyl)-1H-pyrrol-1-yl]-1H-imidazole-5-carboxylic acid (CI-996)

Journal of Medicinal Chemistry ◽

10.1021/jm00068a002 ◽

1993 ◽

Vol 36 (16) ◽

pp. 2253-2265 ◽

Cited By ~ 9

Author(s):

Ila Sircar ◽

John C. Hodges ◽

John Quin ◽

Amy M. Bunker ◽

R. Thomas Winters ◽

...

Keyword(s):

Angiotensin Ii ◽

Carboxylic Acid ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Imidazole Derivatives ◽

Structure Activity

Download Full-text

ChemInform Abstract: Nonpeptide Angiotensin II Receptor Antagonists. Part 4. Synthesis and Biological Evaluation of 4-Acrylamide-1H-imidazole Derivatives.

ChemInform ◽

10.1002/chin.199848121 ◽

2010 ◽

Vol 29 (48) ◽

pp. no-no

Author(s):

T. OKAZAKI ◽

T. WATANABE ◽

K. KIKUCHI ◽

A. SUGA ◽

M. SHIBASAKI ◽

...

Keyword(s):

Angiotensin Ii ◽

Biological Evaluation ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Imidazole Derivatives ◽

Synthesis And Biological Evaluation

Download Full-text

Novel Angiotensin II Receptor Antagonists. Design, Synthesis, and in Vitro Evaluation of Dibenzo[a,d]cycloheptene and Dibenzo[b,f]oxepin Derivatives. Searching for Bioisosteres of Biphenyltetrazole Using a Three-Dimensional Search Technique

Journal of Medicinal Chemistry ◽

10.1021/jm00014a024 ◽

1995 ◽

Vol 38 (14) ◽

pp. 2728-2741 ◽

Cited By ~ 38

Author(s):

Ryuichi Kiyama ◽

Tsunetoshi Honma ◽

Kunio Hayashi ◽

Masayoshi Ogawa ◽

Mariko Hara ◽

...

Keyword(s):

Angiotensin Ii ◽

Three Dimensional ◽

Angiotensin Ii Receptor ◽

Search Technique ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Design Synthesis ◽

In Vitro Evaluation

Download Full-text

In vitro inhibition screening of human hepatic P 450 enzymes by five angiotensin-II receptor antagonists

European Journal of Clinical Pharmacology ◽

10.1007/s002280050731 ◽

2000 ◽

Vol 56 (2) ◽

pp. 135-140 ◽

Cited By ~ 42

Author(s):

P. Taavitsainen ◽

K. Kiukaanniemi ◽

O. Pelkonen

Keyword(s):

Angiotensin Ii ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

In Vitro Inhibition

Download Full-text

ChemInform Abstract: Nonpeptide Angiotensin II Receptor Antagonists. Part 2. Design, Synthesis, and Structure-Activity Relationships of 2-Alkyl-4-(1H-pyrrol-1-yl)-1H-imidazole Derivatives: Profile of 2-Propyl-1-((2′-(1H-tetrazol-5-yl)-(1,1′-biphenyl)-4-yl

ChemInform ◽

10.1002/chin.199352180 ◽

2010 ◽

Vol 24 (52) ◽

pp. no-no

Author(s):

I. SIRCAR ◽

J. C. HODGES ◽

J. III QUIN ◽

A. M. BUNKER ◽

R. T. WINTERS ◽

...

Keyword(s):

Angiotensin Ii ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Imidazole Derivatives ◽

Structure Activity

Download Full-text

The Effect of Angiotensin II and Angiotensin II Receptor Antagonists on In Vitro Maturation of Mouse Oocytes

Clinical Science ◽

10.1042/cs093014pb ◽

1997 ◽

Vol 93 (s37) ◽

pp. 14P-14P

Author(s):

R Edwards ◽

S D Fleming ◽

A Pitten ◽

F Broughton Pipkin

Keyword(s):

Angiotensin Ii ◽

In Vitro Maturation ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Mouse Oocytes

Download Full-text

QSAR and pharmacophore approach on substituted imidazole derivatives as angiotensin II receptor antagonists

Medicinal Chemistry Research ◽

10.1007/s00044-013-0638-9 ◽

2013 ◽

Vol 23 (2) ◽

pp. 660-681 ◽

Cited By ~ 4

Author(s):

Mukesh C. Sharma ◽

Smita Sharma ◽

Pratibha Sharma ◽

Ashok Kumar ◽

Kamlendra Singh Bhadoriya

Keyword(s):

Angiotensin Ii ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Imidazole Derivatives

Download Full-text

Studies on Nonpeptide Angiotensin II Receptor Antagonists. IV. Synthesis and Biological Evaluation of 4-Acrylamide-1H-imidazole Derivatives.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.46.973 ◽

1998 ◽

Vol 46 (6) ◽

pp. 973-981 ◽

Cited By ~ 3

Author(s):

Toshio OKAZAKI ◽

Toshihiro WATANABE ◽

Kazumi KIKUCHI ◽

Akira SUGA ◽

Masayuki SHIBASAKI ◽

...

Keyword(s):

Angiotensin Ii ◽

Biological Evaluation ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Imidazole Derivatives ◽

Synthesis And Biological Evaluation

Download Full-text