2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors

1992 ◽  
Vol 35 (13) ◽  
pp. 2363-2368 ◽  
Author(s):  
Gloria Cristalli ◽  
Alessandra Eleuteri ◽  
Sauro Vittori ◽  
Rosaria Volpini ◽  
Martin J. Lohse ◽  
...  
Keyword(s):  
Adenosine Receptors ◽  
Selective Agonists ◽  
Derivatives Of ◽  
A2 Adenosine Receptors

New 2-Alkynyl Derivatives of the Acyclic Nucleoside 9-(2,3-Dihydroxypropyl)adenine and Their 6-Guanidinopurine Counterparts as Potential Effectors of Adenosine Receptors

2003 ◽  
Vol 68 (11) ◽  
pp. 2201-2218 ◽  
Author(s):  
Michal Česnek ◽  
Antonín Holý ◽  
Milena Masojídková
Keyword(s):  
Adenosine Receptors ◽  
Sonogashira Coupling ◽  
Acyclic Nucleoside ◽  
Derivatives Of

A series of the new 2-alkynyl derivatives of the acyclic nucleoside 9-(2,3-dihydroxypropyl)- adenine and their 6-guanidinopurine analogues were prepared by the Sonogashira coupling. The effect of the prepared compounds on A1 and A2A receptors was examined.

A1 and A2 Adenosine Receptors in Synovial Cells from Patients with Rheumatic Diseases

1989 ◽  
pp. 429-433 ◽  
Author(s):  
Claudia Martini ◽  
Gino Giannaccini ◽  
Antonio Lucacchini ◽  
Laura Bazzichi ◽  
Annalia Soletti ◽  
...  
Keyword(s):  
Rheumatic Diseases ◽  
Adenosine Receptors ◽  
Synovial Cells ◽  
A2 Adenosine Receptors

Homospecific regulation of A1 and A2 adenosine receptors

1990 ◽  
Vol 22 ◽  
pp. 431
Author(s):  
A.M. Rosati ◽  
C. Florio ◽  
U. Traversa ◽  
R. Vertua
Keyword(s):  
Adenosine Receptors ◽  
A2 Adenosine Receptors

scholarly journals Adenosine Receptors as Targets for Therapeutic Intervention

2014 ◽  
Vol 11 (1) ◽  
pp. 96-101 ◽  
Author(s):  
B Suvarna
Keyword(s):  
Medical Journal ◽  
Adenosine Receptor ◽  
Adenosine Receptors ◽  
Receptor Subtypes ◽  
Therapeutic Application ◽  
Chemistry Research ◽  
Wide Range ◽  
The World ◽  
Selective Agonists ◽  
Receptor Modulators

Adenosine receptors are major targets of caffeine, the most commonly consumed drug in the world. There is growing evidence that they could also be promising therapeutic targets in a wide range of conditions, including cerebral and cardiac ischaemic diseases, sleep disorders, immune and inflammatory disorders and cancer. After more than three decades of medicinal chemistry research, a considerable number of selective agonists and antagonists of adenosine receptors have been discovered, and some have been clinically evaluated, although none has yet received regulatory approval. However, recent advances in the understanding of the roles of the various adenosine receptor subtypes, and in the development of selective and potent ligands, as discussed in this review, have brought the goal of therapeutic application of adenosine receptor modulators considerably closer. DOI: http://dx.doi.org/10.3126/kumj.v11i1.11054 Kathmandu University Medical Journal Vol.11(1) 2013: 96-101

The second extracellular loop of GPCRs determines subtype-selectivity and controls efficacy as evidenced by loop exchange study at A2 adenosine receptors

2013 ◽  
Vol 85 (9) ◽  
pp. 1317-1329 ◽  
Author(s):  
Benjamin F. Seibt ◽  
Anke C. Schiedel ◽  
Dominik Thimm ◽  
Sonja Hinz ◽  
Farag F. Sherbiny ◽  
...  
Keyword(s):  
Adenosine Receptors ◽  
Extracellular Loop ◽  
Subtype Selectivity ◽  
Exchange Study ◽  
A2 Adenosine Receptors

Effects of amino and ammonio derivatives of adenosine on smooth muscle preparations and mouse neuroblastoma adenylate cyclase

1985 ◽  
Vol 63 (1) ◽  
pp. 58-61 ◽  
Author(s):  
H. P. Baer ◽  
M. Morr
Keyword(s):  
Smooth Muscle ◽  
Adenylate Cyclase ◽  
Adenosine Receptors ◽  
Smooth Muscles ◽  
Mouse Neuroblastoma ◽  
Derivatives Of ◽  
Stimulation Of

Several amino- and ammonio-substituted derivatives of adenosine were tested as effectors of adenosine receptors in different smooth muscle preparations and mouse neuroblastoma adenylate cyclase. The compounds did not affect adenosine receptors in smooth muscles. N6-[3-(trimethylammonio)propyl]adenosine was a weak stimulator of adenylate cyclase, and 3′-amino-3′-deoxyadenosine and 3′-rnonomethylamino-3′-deoxyadenosine antagonized the stimulation of adenylate cyclase by 2-chloroadenosine.

scholarly journals Xanthine functionalized congeners as potent ligands at A2-adenosine receptors

1987 ◽  
Vol 30 (1) ◽  
pp. 211-214 ◽  
Author(s):  
Kenneth A. Jacobson ◽  
Dieter Ukena ◽  
William Padgett ◽  
John W. Daly ◽  
Kenneth L. Kirk
Keyword(s):  
Adenosine Receptors ◽  
A2 Adenosine Receptors

scholarly journals Characterization of Human Striatal A2-Adenosine Receptors Using Radioligand Binding and Photoaffinity Labeling

1992 ◽  
Vol 12 (2) ◽  
pp. 149-169 ◽  
Author(s):  
Xiao-Duo Ji ◽  
Gary L. Stiles ◽  
Philip J.M. van Galen ◽  
Kenneth A. Jacobson
Keyword(s):  
Adenosine Receptors ◽  
Radioligand Binding ◽  
Photoaffinity Labeling ◽  
A2 Adenosine Receptors
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