Studies on neurokinin antagonists. 1. The design of novel tripeptides possessing glutaminyl-D-tryptophylphenylalanine sequence as substance P antagonists

Daijiro Hagiwara; Hiroshi Miyake; Hiroshi Morimoto; Masako Murai; Takashi Fujii; Masaaki Matsuo

doi:10.1021/jm00089a011

Studies on neurokinin antagonists. 1. The design of novel tripeptides possessing glutaminyl-D-tryptophylphenylalanine sequence as substance P antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm00089a011 ◽

1992 ◽

Vol 35 (11) ◽

pp. 2015-2025 ◽

Cited By ~ 15

Author(s):

Daijiro Hagiwara ◽

Hiroshi Miyake ◽

Hiroshi Morimoto ◽

Masako Murai ◽

Takashi Fujii ◽

...

Keyword(s):

Substance P ◽

Substance P Antagonists ◽

Neurokinin Antagonists

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ChemInform Abstract: Studies on Neurokinin Antagonists. Part 4. Synthesis and Structure- Activity Relationships of Novel Dipeptide Substance P Antagonists: N2-( (4R)-4-Hydroxy-1-((1-methyl-1H-indol-3-yl)carbonyl)-L-prolyl)-N-methyl- N-(phenylmethyl)-3-(2-

ChemInform ◽

10.1002/chin.199450217 ◽

2010 ◽

Vol 25 (50) ◽

pp. no-no

Author(s):

D. HAGIWARA ◽

H. MIYAKE ◽

N. IGARI ◽

M. KARINO ◽

Y. MAEDA ◽

...

Keyword(s):

Substance P ◽

Structure Activity Relationships ◽

Structure Activity ◽

Substance P Antagonists ◽

Neurokinin Antagonists

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Studies on Neurokinin Antagonists. 4. Synthesis and Structure-Activity Relationships of Novel Dipeptide Substance P Antagonists: N2-[(4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl]-N-methyl-N-(phenylmethyl)-3-(2-naphthyl)-L-alaninamide and Its Related Compounds

Journal of Medicinal Chemistry ◽

10.1021/jm00039a022 ◽

1994 ◽

Vol 37 (13) ◽

pp. 2090-2099 ◽

Cited By ~ 11

Author(s):

Daijiro Hagiwara ◽

Hiroshi Miyake ◽

Norihiro Igari ◽

Masako Karino ◽

Yasue Maeda ◽

...

Keyword(s):

Substance P ◽

Structure Activity Relationships ◽

Structure Activity ◽

Substance P Antagonists ◽

Neurokinin Antagonists ◽

Related Compounds

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Studies on neurokinin antagonists. 3. Design and structure-activity relationships of new branched tripeptides N.alpha.-(substituted L-aspartyl, L-ornithyl, or L-lysyl)-N-methyl-N-(phenylmethyl)-L-phenylalaninamides as substance P antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm00068a003 ◽

1993 ◽

Vol 36 (16) ◽

pp. 2266-2278 ◽

Cited By ~ 10

Author(s):

Daijiro Hagiwara ◽

Hiroshi Miyake ◽

Kenji Murano ◽

Hiroshi Morimoto ◽

Masako Murai ◽

...

Keyword(s):

Substance P ◽

Structure Activity Relationships ◽

Structure Activity ◽

Substance P Antagonists ◽

Neurokinin Antagonists

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Studies on neurokinin antagonists. 2. Design and structure-activity relationships of novel tripeptide substance P antagonists, N.alpha.-[N.alpha.-(N.alpha.-acetyl-L-threonyl)-N1-formyl-D-tryptophyl]-N-methyl-N-(phenylmethyl)-L-phenylalaninamide and its related compounds

Journal of Medicinal Chemistry ◽

10.1021/jm00095a013 ◽

1992 ◽

Vol 35 (17) ◽

pp. 3184-3191 ◽

Cited By ~ 21

Author(s):

Daijiro Hagiwara ◽

Hiroshi Miyake ◽

Hiroshi Morimoto ◽

Masako Murai ◽

Takashi Fujii ◽

...

Keyword(s):

Substance P ◽

Structure Activity Relationships ◽

Structure Activity ◽

Substance P Antagonists ◽

Neurokinin Antagonists ◽

Related Compounds

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Variations in affinities for the NK1 receptor: differences between the non-peptide substance P antagonists RP 67580 and CP-96,345 and the agonist septide

Regulatory Peptides ◽

10.1016/0167-0115(93)90066-h ◽

1993 ◽

Vol 46 (1-2) ◽

pp. 300-303 ◽

Cited By ~ 28

Author(s):

Véronique Fardin ◽

Frédéric Foucault ◽

Marie Dominique Bock ◽

Annie Jolly ◽

Odile Flamand ◽

...

Keyword(s):

Substance P ◽

Nk1 Receptor ◽

Substance P Antagonists

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ChemInform Abstract: Morpholine-Based Substance P Antagonists: Assessment of the 3-Point Binding Model.

ChemInform ◽

10.1002/chin.199509148 ◽

2010 ◽

Vol 26 (9) ◽

pp. no-no

Author(s):

T. LADDUWAHETTY ◽

L. KEOWN ◽

M. A. CASCIERI ◽

S. SADOWSKI

Keyword(s):

Substance P ◽

Binding Model ◽

Substance P Antagonists

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Substance P antagonists as a therapeutic approach to improving outcome following traumatic brain injury

Neurotherapeutics ◽

10.1016/j.nurt.2009.10.018 ◽

2010 ◽

Vol 7 (1) ◽

pp. 74-80 ◽

Cited By ~ 37

Author(s):

Robert Vink ◽

Corinna Heuvel

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Substance P ◽

Therapeutic Approach ◽

Substance P Antagonists

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Novel, Potent, and Orally Active Substance P Antagonists: Synthesis and Antagonist Activity of N-Benzylcarboxamide Derivatives of Pyrido[3,4-b]pyridine

Journal of Medicinal Chemistry ◽

10.1021/jm00016a014 ◽

1995 ◽

Vol 38 (16) ◽

pp. 3106-3120 ◽

Cited By ~ 51

Author(s):

Hideaki Natsugari ◽

Yoshinori Ikeura ◽

Yutaka Kiyota ◽

Yuji Ishichi ◽

Takenori Ishimaru ◽

...

Keyword(s):

Substance P ◽

Active Substance ◽

Antagonist Activity ◽

Substance P Antagonists ◽

Orally Active ◽

Derivatives Of

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Potential of Substance P Antagonists as Antiemetics

Antiemetic Therapy ◽

10.1159/000071411 ◽

2003 ◽

pp. 78-97 ◽

Cited By ~ 1

Author(s):

P. Diemunsch ◽

L. Gr�lot

Keyword(s):

Substance P ◽

Substance P Antagonists

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Clinical evidence that substance P antagonists are well-tolerated antidepressants

Psychoneuroendocrinology ◽

10.1016/s0306-4530(00)90113-6 ◽

2000 ◽

Vol 25 ◽

pp. S27

Author(s):

Mark S. Kramer ◽

Neal Cutler ◽

John Feighner ◽

Ram Shrivastava ◽

John Carman ◽

...

Keyword(s):

Substance P ◽

Clinical Evidence ◽

Substance P Antagonists

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