Substitution on the Phe3 aromatic ring in cyclic .delta. opioid receptor-selective dermorphin/deltorphin tetrapeptide analogs: electronic and lipophilic requirements for receptor affinity

1992 ◽  
Vol 35 (9) ◽  
pp. 1535-1541 ◽  
Author(s):  
Deborah L. Heyl ◽  
Henry I. Mosberg
Keyword(s):  
Aromatic Ring ◽  
Opioid Receptor ◽  
Delta Opioid Receptor ◽  
Receptor Affinity

Topographical conformations of the deltorphins predicate .delta. opioid receptor affinity

1993 ◽  
Vol 115 (18) ◽  
pp. 8503-8504 ◽  
Author(s):  
Sharon D. Bryant ◽  
Severo Salvadori ◽  
Martti Attila ◽  
Lawrence H. Lazarus
Keyword(s):  
Opioid Receptor ◽  
Delta Opioid Receptor ◽  
Receptor Affinity

scholarly journals Synthesis and binding properties of deltorphin I analogues containing (R) and (S)-alpha-hydroxymethylnaphtylalanine.

2001 ◽  
Vol 48 (4) ◽  
pp. 1165-1168 ◽  
Author(s):  
A Olma ◽  
A Gniadzik ◽  
A W Lipkowski ◽  
M Lachwa
Keyword(s):  
Amino Acid ◽  
Opioid Receptor ◽  
Delta Opioid Receptor ◽  
Binding Properties ◽  
Lower Affinity ◽  
Receptor Affinity ◽  
Amino Acid Enantiomers ◽  
Phenylalanine Residue ◽  
Delta Receptors ◽  
Disubstituted Amino Acid

New analogues of deltorphin I (DT I), in which the phenylalanine residue in position 3 is substituted with amphiphilic alpha,alpha-disubstituted amino acid enantiomers, (R) and (S)-alpha-hydroxymethylnaphtylalanine, were synthesized and tested for mu and delta opioid receptor affinity and selectivity. Although both analogues have lower affinity to delta receptors than DT I, they both expressed specificity to delta receptors.

Levels of Delta-Opioid Receptor mRNA in Morphine-Tolerant Mice

Analgesia ◽  
1995 ◽  
Vol 1 (3) ◽  
pp. 195-200 ◽  
Author(s):  
Benjamin Kest ◽  
Shirzad Jenab ◽  
Charles E. Inturrisi
Keyword(s):  
Opioid Receptor ◽  
Delta Opioid Receptor ◽  
Receptor Mrna

scholarly journals A single residue, aspartic acid 95, in the delta opioid receptor specifies selective high affinity agonist binding.

1993 ◽  
Vol 268 (31) ◽  
pp. 23055-23058
Author(s):  
H Kong ◽  
K Raynor ◽  
K Yasuda ◽  
S.T. Moe ◽  
P.S. Portoghese ◽  
...  
Keyword(s):  
Aspartic Acid ◽  
Opioid Receptor ◽  
Delta Opioid Receptor ◽  
Agonist Binding ◽  
High Affinity
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