Effect of the 7-amino substituent on the inhibitory potency of mechanism-based isocoumarin inhibitors for porcine pancreatic and human neutrophil elastases: a 1.85-.ANG. x-ray structure of the complex between porcine pancreatic elastase and 7-[(N-tosylphenylalanyl)amino]-4-chloro-3-methoxyisocoumarin

1992 ◽  
Vol 35 (6) ◽  
pp. 1121-1129 ◽  
Author(s):  
Maria A. Hernandez ◽  
James C. Powers ◽  
Jan Glinski ◽  
Jozef Oleksyszyn ◽  
J. Vijayalakshmi ◽  
...  
Keyword(s):  
Human Neutrophil ◽  
Inhibitory Potency ◽  
Pancreatic Elastase ◽  
X Ray ◽  
Porcine Pancreatic Elastase

scholarly journals Human lysosomal elastase. Catalytic and immunological properties

1976 ◽  
Vol 155 (2) ◽  
pp. 265-271 ◽  
Author(s):  
P M. Starkey ◽  
A J. Barrett
Keyword(s):  
Human Neutrophil ◽  
Serine Proteinase ◽  
Ph Optimum ◽  
Human Spleen ◽  
Pancreatic Elastase ◽  
Good Substrate ◽  
Endopeptidase Activity ◽  
Specific Antisera ◽  
Porcine Pancreatic Elastase ◽  
Effect Of Inhibitors

1. The elastase of human spleen was shown to exhibit endopeptidase activity against azo-casein and elastin. 2. Activity against several synthetic substrates was detected, and benzyloxycarbonyl-L-alanine 2-naphthyl ester was found to be a good substrate for routine use. 3. The enzyme showed a broad pH optimum in the range of 8.2-9.2 against azo-casein and the synthetic substrate. 4. The effect of inhibitors on the spleen elastase showed it to be a serine proteinase with a specificity similar to that of porcine pancreatic elastase. 5. Specific antisera were raised against the enzyme, and it was shown to be immunologically identical with the lysosomal elastase of human neutrophil leucocytes.

X-ray diffraction analysis of the inhibition of porcine pancreatic elastase by a peptidyl trifluoromethylketone

1988 ◽  
Vol 201 (2) ◽  
pp. 423-428 ◽  
Author(s):  
Lori H. Takahashi ◽  
R. Radhakrishnan ◽  
Richard E. Rosenfield ◽  
Edgar F. Meyer ◽  
Diane Amy Trainor ◽  
...  
Keyword(s):  
Diffraction Analysis ◽  
X Ray Diffraction ◽  
Pancreatic Elastase ◽  
X Ray ◽  
Porcine Pancreatic Elastase

Defenses of the Hamster Lung against Human Neutrophil and Porcine Pancreatic Elastase

Respiration ◽  
1988 ◽  
Vol 54 (1) ◽  
pp. 1-15 ◽  
Author(s):  
Phillip J. Stone ◽  
Edgar C. Lucey ◽  
James D. Calore ◽  
Mary P. McMahon ◽  
Gordon L. Snider ◽  
...  
Keyword(s):  
Human Neutrophil ◽  
Pancreatic Elastase ◽  
Porcine Pancreatic Elastase
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