Synthesis and biological activities of fatty acid conjugates of a cyclic lactam .alpha.-melanotropin

1992 ◽  
Vol 35 (1) ◽  
pp. 118-123 ◽  
Author(s):  
Fahad Al-Obeidi ◽  
Victor J. Hruby ◽  
Nader Yaghoubi ◽  
Mohamed M. Marwan ◽  
Mac E. Hadley
Keyword(s):  
Fatty Acid ◽  
Biological Activities ◽  
Cyclic Lactam

Biological Activities of Melanotropic Peptide Fatty Acid Conjugates

1991 ◽  
Vol 4 (4) ◽  
pp. 180-185 ◽  
Author(s):  
MAC E. HADLEY ◽  
FAHAD AL-OBEIDI ◽  
VICTOR J. HRUBY ◽  
JONATHAN C. WEINRACH ◽  
DOUGLAS FREEDBERG ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Biological Activities

scholarly journals Determination of Fatty Acid and Essential Oil Constituents and Biological Activities on Ranunculus pedatus Subsp. pedatus

2014 ◽  
Vol 26 (7) ◽  
pp. 2156-2160 ◽  
Author(s):  
T. Erdogan ◽  
T. Gonenc ◽  
B. Demirci ◽  
B. Kivçak ◽  
K.H.C. Baser
Keyword(s):  
Fatty Acid ◽  
Essential Oil ◽  
Biological Activities

Abstract MP03: Plasma Sphingolipids and Risks of Heart Failure and Atrial Fibrillation in Older Adults: The Cardiovascular Health Study

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Rozenn N Lemaitre ◽  
Paul N Jensen ◽  
Barbara McKnight ◽  
Andrew Hoofnagle ◽  
Irena B King ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Fatty Acid ◽  
Lower Risk ◽  
Cardiovascular Health ◽  
Biological Activities ◽  
Experimental Studies ◽  
Health Study ◽  
Cardiovascular Health Study

Introduction: Ceramides and sphingomyelins (sphingolipids) are circulating lipids involved in multiple physiological pathways relevant to heart failure (HF) and atrial fibrillation (AF), including apoptosis, oxidative stress, and inflammation. Experimental studies suggest that sphingolipids with different saturated fatty acids exhibit different biological activities, but their relationships with HF and AF are unknown. Hypothesis: Higher levels of plasma ceramide and sphingomyelin that contain the fatty acid 16:0 are associated with higher risks of HF and AF; and higher levels of ceramides and sphingomyelins that contain the fatty acid 20:0, 22:0 or 24:0 are associated with lower risks. Methods: We measured sphingolipids in the Cardiovascular Health Study (CHS) in plasma samples from 1994-95 (N=4026) or from 1992-93 (N=586). We assessed the separate associations of the levels of 8 sphingolipids with risks of incident HF and incident AF using Cox regression. A p-value threshold of 0.006 was used to account for multiple testing. Results: Among 4,612 participants, 1179 incident HF and 1198 incident AF occurred during >40,000 person-years of follow-up. In adjusted analyses, higher levels of Cer-16 (ceramide with 16:0) and SM-16 (sphingomyelin with 16:0) were associated with higher risk of incident HF, but not with risk of incident AF (Table). In contrast, higher levels of Cer-20, Cer-22 and Cer-24 were each associated with lower risk of AF, but not with risk of HF. Higher levels of SM-20, SM-22, and SM-24 tended to be associated with lower risks of AF and HF, with only the association of SM-20 with AF significant. Conclusions: Plasma levels of ceramide and sphingomyelin with 16:0 show different associations with HF and AF than species with 20:0, 22:0 or 24:0. Associations of Cer-16 and SM-16 specifically with higher risk of HF may be due to a role of apoptosis in HF. The novel findings that Cer-20, Cer-22, and Cer-24 are associated with lower risk of AF warrant further examination of the role of these sphingolipids in protecting from AF.

Design, Synthesis, and Biological Activities of Cyclic Lactam Peptide Analogues of Dynorphin A(1−11)-NH21

1996 ◽  
Vol 39 (5) ◽  
pp. 1136-1141 ◽  
Author(s):  
Feng-Di T. Lung ◽  
Nathan Collins ◽  
Dagmar Stropova ◽  
Peg Davis ◽  
Henry I. Yamamura ◽  
...  
Keyword(s):  
Biological Activities ◽  
Dynorphin A ◽  
Design Synthesis ◽  
Peptide Analogues ◽  
Cyclic Lactam

scholarly journals Effect of Mild Salinity Stress on the Growth, Fatty Acid and Carotenoid Compositions, and Biological Activities of the Thermal Freshwater Microalgae Scenedesmus sp.

Biomolecules ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 1515
Author(s):  
Wiem Elloumi ◽  
Ahlem Jebali ◽  
Amina Maalej ◽  
Mohamed Chamkha ◽  
Sami Sayadi
Keyword(s):  
Fatty Acid ◽  
Biological Activities ◽  
Culture Conditions ◽  
Control Culture ◽  
Good Growth ◽  
Mild Stress ◽  
Cytotoxicity Test ◽  
Freshwater Microalgae ◽  
Therapeutic Value ◽  
Potential Applications

Carotenoids have strong antioxidant activity as well as therapeutic value. Their production has been induced in algae under stressful culture conditions. However, the extreme culture conditions lead to the Programmed Cell Death (PCD) of algae, which affects their growth and productivity. This study was performed to evaluate the effect of salinity on the physiological and biochemical traits of Scenedesmus sp., thermal freshwater microalgae from Northern Tunisia. It was cultured under different NaCl concentrations ranging from 0 to 60 g/L. Results showed a good growth and high contents of total chlorophyll and carotenoids in Scenedesmus sp. cultured at 10 g/L of NaCl (salt-stressed 10 (Ss10)). The pigment composition of the Ss10 extract was acquired using HPLC–MS, and showed that the carotenoid fraction is particularly rich in xanthophylls. Moreover, the antioxidant (DPPH and FRAP) and enzymatic inhibition (tyrosinase and elastase) activities of the Ss10 extract were higher compared to those of the control culture. In addition, the cytotoxicity test on B16 cells showed that the Ss10 extract was non-toxic for all tested concentrations below 100 µg/mL. It also showed a rich unsaturated fatty acid (FA) composition. Therefore, these findings suggest that Scenedesmus sp. strain cultivated under mild stress salinity could be a source of biomolecules that have potential applications in the nutraceutical and cosmeceutical industries.

scholarly journals Effects of Different Cultivation Parameters on the Production of Surfactin Variants by a Bacillus subtilis Strain

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2675 ◽  
Author(s):  
Attila Bartal ◽  
Aruna Vigneshwari ◽  
Bettina Bóka ◽  
Mónika Vörös ◽  
István Takács ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Metal Ions ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Carbon Sources ◽  
Bacillus Species ◽  
Subtilis Strain ◽  
Fatty Acid Chain ◽  
Characteristic Features ◽  
Surfactin Production

Surfactins are lipopeptide-type biosurfactants produced mainly by Bacillus species, consisting of a peptide loop of seven amino acids and a hydrophobic fatty acid chain (C12–C16). These molecules have been proven to exhibit various biological activities; thus, their therapeutic and environmental applications are considered. Within the surfactin lipopeptide family, there is a wide spectrum of different homologues and isomers; to date, more than 30 variants have been described. Since the newest members of these lipopeptides were described recently, there is no information that is available on their characteristic features, e.g., the dependence of their production from different cultivation parameters. This study examined the effects of both the different carbon sources and various metal ions on the surfactin production of a selected B. subtilis strain. Among the applied carbon sources, fructose and xylose had the highest impacts on the ratio of the different variants, regarding both the peptide sequences and the lengths of the fatty acids. Furthermore, the application of metal ions Mn2+, Cu2+ and Ni2+ in the media completely changed the surfactin variant compositions of the fermenting broths leading to the appearance of methyl esterified surfactin forms, and resulted in the appearance of novel surfactin variants with fatty acid chains containing no more than 11 carbon atoms.

scholarly journals Role of caffeic and chlorogenic acid in the modulation of cellular fatty acid uptake

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Mirko Marino ◽  
Massimiliano Tucci ◽  
Valentina Taverniti ◽  
Patrizia Riso ◽  
Marisa Porrini ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Chlorogenic Acid ◽  
Phenolic Acids ◽  
Lipid Accumulation ◽  
Biological Activities ◽  
Fatty Acid Uptake ◽  
Cellular Fatty Acid ◽  
Bioactive Molecules ◽  
Acid Uptake

AbstractPolyphenols are bioactive molecules widely distributed in numerous foods such as fruits, vegetables, tea, coffee, cocoa and beverages. Their main classification include flavonoids (i.e. flavonols, flavones, flavanones, flavanols, anthocyanins, and isoflavones), non-flavonoids (i.e. lignans and stilbens) and phenolic acids (i.e. hydroxycinnamic and hydroxybenzoic acids)(1). Caffeic acid (CA) and chlorogenic acid (CGA; an ester of CA and quinic acid) are the major representatives of hydroxycinnamic acids. Accumulating evidence has demonstrated that CA and CGA may exert different biological activities, including antioxidant, anti-inflammatory, antidiabetic, and antihypertensive(2). Despite these promising and diverse anti-atherosclerotic actions, investigations addressing the effect of CA and CGA on atherogenesis are scarce.The present study evaluated the capacity of CA and CGA to reduce lipid accumulation in macrophages derived from monocytic THP-1 cells. THP-1-derived macrophages were incubated with fatty acids (500 μM oleic/palmitic acid, 2:1 ratio) and different concentrations (from 0.03 to 3 μM) of CA and CGA, alone or in combination. Lipid accumulation was quantified spectrophotometrically (excitation: 544 nm, emission: 590 nm) with the fluorescent dye, Nile red. The fold increase compared to the control (without fatty acids) was calculated. In addition, the expression of several transcription factors including peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT/enhancer-binding protein (CEBP), as potential mechanisms involved in the regulation of lipid accumulation, was evaluated by real time PCR.Analysis of variance (ANOVA) was used to assess the effect of the different concentrations of CA and CGA on lipid accumulation in THP-1 macrophages following stimulation with FA.The preliminary results obtained have shown a significant increase in lipid accumulation following fatty acid exposure (p < 0.0001). Incubation with CA and CGA did not reduce lipid accumulation in THP-1 derived macrophages, while the combination of CA + CGA at 0.03, 0.3 and 3 μM (p < 0.01) decreased cellular fatty acid uptake at all concentrations tested by -28%, -32%, -23%, respectively. An apparent modulation of the transcriptional activity of PPARγ, but not CEBP, was observed following the combination of phenolic acids.In conclusion, the incubation of CA + CGA at physiologically relevant concentrations, but not the single compounds, seem to reduce the uptake of fatty acids in THP-1-derived macrophages. Further experiments are ongoing in order to confirm the findings obtained and to better identify the mechanisms of action involved in the reduction of lipid accumulation as a key phenomenon of atherogenesis.

Synthesis and biological activities of cyclic lactam peptides as substrates for non-receptors PTKs

1999 ◽  
Vol 6 (2-3) ◽  
pp. 117-121
Author(s):  
Paolo Ruzza ◽  
Arianna Donella-Deana ◽  
Andrea Calderan ◽  
Barbara Biondi ◽  
Lorenzo A. Pinna ◽  
...  
Keyword(s):  
Biological Activities ◽  
Cyclic Lactam

scholarly journals Distinct biological activities of isomers from several families of branched fatty acid esters of hydroxy fatty acids (FAHFAs)

2021 ◽  
Vol 62 ◽  
pp. 100108
Author(s):  
Pratik Aryal ◽  
Ismail Syed ◽  
Jennifer Lee ◽  
Rucha Patel ◽  
Andrew T. Nelson ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Biological Activities ◽  
Hydroxy Fatty Acids ◽  
Fatty Acid Esters ◽  
Acid Esters
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