3-(Alkylamino)-4H-pyrido[4,3-e]1,2,4-thiadiazine 1,1-dioxides as powerful inhibitors of insulin release from rat pancreatic B-cells: a new class of potassium channel openers?

1993 ◽  
Vol 36 (21) ◽  
pp. 3211-3213 ◽  
Author(s):  
Bernard Pirotte ◽  
Pascal de Tullio ◽  
Philippe Lebrun ◽  
Marie Helene Antoine ◽  
Jeanine Fontaine ◽  
...  
Keyword(s):  
B Cells ◽  
Potassium Channel ◽  
Insulin Release ◽  
Potassium Channel Openers ◽  
New Class ◽  
Pancreatic B Cells

Ontogeny of salivary peptide P-C like immunoreactivity in human pancreatic B-cells

1983 ◽  
Vol 103 (4) ◽  
pp. 552-557 ◽  
Author(s):  
Seiki Ito ◽  
Satoko Isemura ◽  
Eiichi Saitoh ◽  
Kazuo Sanada ◽  
Toshimitsu Suzuki ◽  
...  
Keyword(s):  
B Cells ◽  
Insulin Release ◽  
Protein C ◽  
Calcium Concentration ◽  
Salivary Protein ◽  
Human Pancreas ◽  
Amino Acid Residues ◽  
Salivary Peptide ◽  
Pancreatic B Cells ◽  
Foetal Pancreas

Abstract. An immunohistochemical study using antisera against proline rich salivary peptide P-C and insulin, glucagon, somatostatin and pancreatic polypeptide antisera was carried out on the foetal pancreas at different stages and on the newborn infant's, infant's, child's and adult pancreas to examine the time at which salivary peptide P-C like immunoreactivity appeared in the human pancreas. Salivary peptide P-C like immunoreactive cells first appeared as a few scattered cells in the foetal pancreas after 16 weeks of gestation and gradually increased in numbers during gestation. The cells corresponded only to insulin immunoreactive cells in the foetal, newborn infant's, infant's, child's and adult pancreas. Only some of the insulin immunoreactive cells in the foetal pancreas contained salivary peptide P-C like immunoreactivity while the majority of those in the infant's pancreas and all those in the child's and adult pancreas did so. The findings, together with the fact that the full sequence of salivary peptide P-C is identical to the COOH-terminal 44 amino acid residues of Salivary Protein C, led to the possibility that peptide P-C like immunoreactivity in the human pancreatic B-cells was not a moiety of the precursor of insulin and pro-insulin, but a moiety of Salivary Protein C. It has been suggested that, in saliva, Salivary Protein C aids in maintenance of the calcium concentration. Based on the hypothesis that peptide P-C like immunoreactivity in the human pancreatic B-cells may play some role in insulin release through the maintenance of the calcium concentration, the present finding seems to explain the fact that the mechanism for insulin release in the foetal pancreas is immature in spite of sufficient biosynthesis of insulin.

Role of CYP2E1 in ketone-stimulated insulin release in pancreatic B-cells

2004 ◽  
Vol 67 (5) ◽  
pp. 875-884 ◽  
Author(s):  
Diane J.Lees Murdock ◽  
Jacqueline Clarke ◽  
Peter R. Flatt ◽  
Yvonne A. Barnett ◽  
Christopher R. Barnett
Keyword(s):  
B Cells ◽  
Insulin Release ◽  
Pancreatic B Cells

scholarly journals Die ultrastrukturele, morfometriese evaluering van die mikrotubulere stelsel in gestimuleerde B-selle van die pankreas

1992 ◽  
Vol 11 (4) ◽  
pp. 127-135
Author(s):  
A. Crous ◽  
A. M. De Beer ◽  
E. J. Visser
Keyword(s):  
B Cells ◽  
Insulin Release ◽  
Insulin Response ◽  
High Magnification ◽  
Tissue Samples ◽  
Islet Tissue ◽  
Pancreatic B Cells ◽  
Complete Cell

The intracellular distribution of microtubules in pancreatic B-cells was studied morphometrically to elucidate the positive correlation between microtubular content and the rate of insulin release found by biochemical investigations. Rat islet tissue was glucose stimulated under in vivo and in vitro (isolated islets) conditions and tissue samples taken to represent both phases of the phasic insulin response. Electron micrographs (x40 000) of individual B-cells were assembled into montages to obtain complete cell profiles at high magnification.

Pinacidil inhibits insulin release by increasing K+ outflow from pancreatic B-cells

1988 ◽  
Vol 156 (2) ◽  
pp. 283-286 ◽  
Author(s):  
Philippe Lebrun ◽  
Vincent Devreux ◽  
Marcel Hermann ◽  
André Herchuelz
Keyword(s):  
B Cells ◽  
Insulin Release ◽  
Pancreatic B Cells

Effects of islet hormones on insulin secretion from cloned B cell lines, HIT-T15 and RINm5F

1989 ◽  
Vol 121 (3) ◽  
pp. 479-485 ◽  
Author(s):  
D. G. Lambert ◽  
T. W. Atkins
Keyword(s):  
Insulin Secretion ◽  
B Cells ◽  
Insulin Release ◽  
Pancreatic Polypeptide ◽  
Islet Cell ◽  
Fine Tuning ◽  
Rinm5f Cells ◽  
Islet Hormones ◽  
Pancreatic B Cells ◽  
Islet Cell Hormones

ABSTRACT The effects of the islet cell hormones glucagon, somatostatin-28 and pancreatic polypeptide on insulin secretion from cultured cloned pancreatic B cells (HIT-T15 and RINm5F) have been investigated. Glucagon stimulates the secretion of insulin from HIT-T15 cells in the absence and presence of glucose and from RINm5F cells in the absence and presence of glyceraldehyde. HIT-T15 cells were more sensitive to the stimulatory effect of glucagon than RINm5F cells. Somatostatin-28 and pancreatic polypeptide, both alone and in combination, reduced glucose- and glucagon-stimulated insulin release from HIT-T15 cells and glyceraldehyde- and glucagon-stimulated insulin release from RINm5F cells. HIT-T15 cells were more sensitive to the inhibitory actions of somatostatin-28 and pancreatic polypeptide than RINm5F cells. This study supports the hypothesis that insulin release from normal B cells may be modified by the paracrine activity of islet hormones, glucagon, somatostatin and pancreatic polypeptide and probably occurs before any fine tuning imposed by subsequently released insulin. Journal of Endocrinology (1989) 121, 479–485

ATP sensitive potassium channel openers: A new class of ocular hypotensive agents

2019 ◽  
Vol 178 ◽  
pp. 223-224
Author(s):  
Philippe Trechot ◽  
Jean-Baptiste Conart ◽  
Fanny Trechot
Keyword(s):  
Potassium Channel ◽  
Potassium Channel Openers ◽  
New Class

scholarly journals Ion channels involved in insulin release are activated by osmotic swelling of pancreatic B-cells

1998 ◽  
Vol 1370 (1) ◽  
pp. 8-16 ◽  
Author(s):  
Gisela Drews ◽  
Günther Zempel ◽  
Peter Krippeit-Drews ◽  
Stefan Britsch ◽  
Gillian L Busch ◽  
...  
Keyword(s):  
B Cells ◽  
Ion Channels ◽  
Insulin Release ◽  
Osmotic Swelling ◽  
Pancreatic B Cells
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