Quinolone antibacterials: synthesis and biological activity of carbon isosteres of the 1-piperazinyl and 3-amino-1-pyrrolidinyl side chains

1993 ◽  
Vol 36 (14) ◽  
pp. 1964-1970 ◽  
Author(s):  
Edgardo Laborde ◽  
John S. Kiely ◽  
Townley P. Culbertson ◽  
Lawrence E. Lesheski
Keyword(s):  
Biological Activity ◽  
Side Chains

Different positions of amide side chains on the benzimidazo[1,2-a]quinoline skeleton strongly influence biological activity

2018 ◽  
Vol 42 (9) ◽  
pp. 7096-7104 ◽  
Author(s):  
Nataša Perin ◽  
Jasna Alić ◽  
Sandra Liekens ◽  
Arthur Van Aerschot ◽  
Peter Vervaeke ◽  
...  
Keyword(s):  
Biological Activity ◽  
Antiviral Activity ◽  
Side Chains

Benzimidazo[1,2-a]quinolines substituted with amide chains have been evaluated for their antiproliferative, antibacterial and antiviral activity in vitro.

scholarly journals Epimeric Mixtures of Brassinosteroid Analogs: Synthesis, Plant Growth, and Germination Effects in Tomato (Lycopersicum esculentum Mill.)

Agronomy ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 808
Author(s):  
Nitza Soto ◽  
César González ◽  
Marco Mellado ◽  
Andrés F. Olea ◽  
Yamilet Coll ◽  
...  
Keyword(s):  
Biological Activity ◽  
Plant Growth ◽  
Potential Application ◽  
Growth And Development ◽  
Side Chains ◽  
Lycopersicum Esculentum ◽  
Good Level ◽  
Hyodeoxycholic Acid ◽  
Pure Compounds

Brassinosteroids (BRs) play an important role in the growth and development of plants. Herein, we describe the synthesis of epimeric mixtures of BR analogs with 24-norcholane type side chains, S/R configuration at C22 and A/B ring cis-type fusion. All epimeric mixtures were synthetized from hyodeoxycholic acid. The biological activity of mixtures was evaluated by using rice lamina inclination test and germination of tomato (Lycopersicum esculentum) seeds. The results show that these epimeric mixtures exhibit similar bioactivity to brassinolide in both bioassays. Thus, our results corroborate that the A/B junction has almost no effect on bioactivity and open the possibility of using epimeric mixtures instead of pure compounds. In this approach, the synthesized BR analogs maintain a good level of bioactivity, whereas the synthesis is shorter, cheaper and with higher yields. All these factors make this alternative very interesting for potential application.

Design, synthesis, and biological activity evaluation of a series of pleuromutilin derivatives with novel C14 side chains

2020 ◽  
Vol 30 (7) ◽  
pp. 126969
Author(s):  
Yun-Ge Li ◽  
Ju-Xian Wang ◽  
Guo-Ning Zhang ◽  
Mei Zhu ◽  
Xue-Fu You ◽  
...  
Keyword(s):  
Biological Activity ◽  
Side Chains ◽  
Design Synthesis ◽  
Activity Evaluation

Structure-activity studies of dermorphin. The role of side chains of amino acid residues on the biological activity of dermorphin

Peptides ◽  
1984 ◽  
Vol 5 (4) ◽  
pp. 687-689 ◽  
Author(s):  
Krzysztof Darłak ◽  
Zbigniew Grzonka ◽  
Pawel Krzaścik ◽  
Piotr Janicki ◽  
S.Witold Gumułka
Keyword(s):  
Biological Activity ◽  
Amino Acid ◽  
Side Chains ◽  
Amino Acid Residues ◽  
Structure Activity

ChemInform Abstract: Synthesis and Biological Activity of Polyacrylamide Analogues with Amino Acid Side Chains.

ChemInform ◽  
2010 ◽  
Vol 26 (44) ◽  
pp. no-no
Author(s):  
A. I. SLIVKIN ◽  
V. L. LAPENKO ◽  
N. S. SUNTSOVA ◽  
G. G. SIROTKINA ◽  
A. T. BELOKHVOSTOVA
Keyword(s):  
Biological Activity ◽  
Amino Acid ◽  
Side Chains ◽  
Amino Acid Side Chains

Prostagiandins IX: 8,12-diiso-PGE2: Effect of steric configuration of side chains on biological activity

1975 ◽  
Vol 9 (1) ◽  
pp. 97-107 ◽  
Author(s):  
R. Ceserani ◽  
C. Gandolfi ◽  
M.M. Usardi ◽  
M. Bergamaschi
Keyword(s):  
Biological Activity ◽  
Side Chains ◽  
Steric Configuration

Structural characterization of a peptoid with lysine-like side chains and biological activity using NMR and computational methods

2013 ◽  
Vol 11 (4) ◽  
pp. 640-647 ◽  
Author(s):  
Ulrich Sternberg ◽  
Esther Birtalan ◽  
Igor Jakovkin ◽  
Burkhard Luy ◽  
Ute Schepers ◽  
...  
Keyword(s):  
Biological Activity ◽  
Computational Methods ◽  
Structural Characterization ◽  
Side Chains

Synthesis and biological activity of polyacrylamide analogs with aminoacid side chains

1995 ◽  
Vol 29 (4) ◽  
pp. 256-258
Author(s):  
A. I. Slivkin ◽  
V. L. Lapenko ◽  
N. S. Suntsova ◽  
G. G. Sirotkina ◽  
A. T. Belokhvostova
Keyword(s):  
Biological Activity ◽  
Side Chains
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