The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (Tiagabine) as an anticonvulsant drug candidate

1993 ◽  
Vol 36 (12) ◽  
pp. 1716-1725 ◽  
Author(s):  
Knud Erik Andersen ◽  
Claus Braestrup ◽  
Frederik C. Groenwald ◽  
Anker S. Joergensen ◽  
Erik B. Nielsen ◽  
...  
Keyword(s):  
Anticonvulsant Drug ◽  
Drug Candidate ◽  
Gaba Uptake ◽  
Structure Activity ◽  
Uptake Inhibitors ◽  
Gaba Uptake Inhibitors

GABA-A agonists and GABA uptake inhibitors: Structure-activity relationships

1990 ◽  
Vol 21 (3) ◽  
pp. 169-188 ◽  
Author(s):  
Erik Falch ◽  
Orla M. Larsson ◽  
Arne Schousboe ◽  
Povl Krogsgaard-Larsen
Keyword(s):  
Gaba Uptake ◽  
Gaba A ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Uptake Inhibitors ◽  
Gaba Uptake Inhibitors

Synthesis of Novel γ-Aminobutyric Acid (GABA) Uptake Inhibitors. 5.1Preparation and Structure−Activity Studies of Tricyclic Analogues of Known GABA Uptake Inhibitors

2001 ◽  
Vol 44 (13) ◽  
pp. 2152-2163 ◽  
Author(s):  
Knud Erik Andersen ◽  
Jan L. Sørensen ◽  
Jesper Lau ◽  
Behrend F. Lundt ◽  
Hans Petersen ◽  
...  
Keyword(s):  
Aminobutyric Acid ◽  
Gaba Uptake ◽  
Structure Activity ◽  
Uptake Inhibitors ◽  
Gaba Uptake Inhibitors

Structure activity relationship of selective GABA uptake inhibitors

2015 ◽  
Vol 23 (10) ◽  
pp. 2480-2488 ◽  
Author(s):  
Stine B. Vogensen ◽  
Lars Jørgensen ◽  
Karsten K. Madsen ◽  
Andreas Jurik ◽  
Nrupa Borkar ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Gaba Uptake ◽  
Structure Activity ◽  
Uptake Inhibitors ◽  
Relationship Of ◽  
Gaba Uptake Inhibitors

Structure-Activity Relationships of Selective GABA Uptake Inhibitors

2006 ◽  
Vol 6 (17) ◽  
pp. 1861-1882 ◽  
Author(s):  
Signe Hog ◽  
Jeremy Greenwood ◽  
Karsten Madsen ◽  
Orla Larsson ◽  
Bente Frolund ◽  
...  
Keyword(s):  
Gaba Uptake ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Uptake Inhibitors ◽  
Gaba Uptake Inhibitors

Synthesis and Biochemical Studies of Spirocyclic Amino Acid Esters, Part 3 Activity of 2-Azaspiro[4.5]decane-6-carboxylates as GABA-Uptake Inhibitors

1996 ◽  
Vol 329 (3) ◽  
pp. 149-154 ◽  
Author(s):  
Wilhelm Fleischhacker ◽  
Silvia Lauritz ◽  
Ernst Urban ◽  
Peter Baumann ◽  
Helmut Bittiger
Keyword(s):  
Amino Acid ◽  
Gaba Uptake ◽  
Amino Acid Esters ◽  
Uptake Inhibitors ◽  
Biochemical Studies ◽  
Gaba Uptake Inhibitors ◽  
Acid Esters
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