Long-chain-substituted uric acid and 5,6-diaminouracil derivatives as novel agents against free radical processes: synthesis and in vitro activity

1993 ◽  
Vol 36 (10) ◽  
pp. 1465-1473 ◽  
Author(s):  
Laurent Fraisse ◽  
Jean Baptiste Verlhac ◽  
Beatrice Roche ◽  
Marie Claude Rascle ◽  
Alain Rabion ◽  
...  
Keyword(s):  
Uric Acid ◽  
Free Radical ◽  
Vitro Activity ◽  
Novel Agents ◽  
In Vitro Activity ◽  
Free Radical Processes ◽  
Radical Processes ◽  
Long Chain

Synthesis, characterization, crystal structure and antiproliferative in vitro activity of long-chain aliphatic thiosemicarbazones and their Ni(II) complexes

Polyhedron ◽  
2007 ◽  
Vol 26 (17) ◽  
pp. 5150-5161 ◽  
Author(s):  
Marisa Belicchi-Ferrari ◽  
Franco Bisceglie ◽  
Giorgio Pelosi ◽  
Silvana Pinelli ◽  
Pieralberto Tarasconi
Keyword(s):  
Crystal Structure ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Long Chain

Study of photobiomodulation effects with violet-blue and red light in experimental oncogenesis

2020 ◽  
Vol 60 (9) ◽  
pp. 618-623
Author(s):  
Evgeniya S. Zhukova ◽  
Tatiana G. Shcherbatyuk ◽  
Arseniy L. Potapov ◽  
Irina A. Chernigina ◽  
Vladimir V. Chernov ◽  
...  
Keyword(s):  
Free Radical ◽  
Tumor Growth ◽  
Electromagnetic Radiation ◽  
Electromagnetic Waves ◽  
Biological Effects ◽  
Red Light ◽  
Free Radical Processes ◽  
Low Intensity ◽  
Radical Processes

Introduction. There is still an open question about the limits of medical use of low-intensity electromagnetic radiation of the optical range in tumor growth due to the risk of increased proliferation of tumor cells. The conditions under which the tumor process is stimulated, as well as the mechanisms of photobiomodulation in oncological pathology, remain unclear. The aim of the study - in vitro evaluation and comparison of the effect of low-intensity electromagnetic radiation with wavelengths of 400, 460 and 660 nm on the activity of free-radical processes in tumor tissue and blood in normal and growing experimental neoplasia. Materials and methods. The study was conducted on biological material obtained from white non-linear rats intact and with subcutaneously transplanted cholangiocellular cancer MS-1. The sources of low-intensity radiation with wavelengths of 400, 460 and 660 nm were led generators. The content of hemoglobin, the activity of superoxide dismutase and catalase, changes in the overall level of free radical processes and antioxidant activity by induced chemiluminescence, and DNA damage by the method of DNA comets were studied. Data analysis was performed using nonparametric statistics methods. Results. The multidirectional effect of radiation with wavelengths of 400, 460 and 660 nm on free-radical homeostasis indicators at the early and late stages of tumor growth, as well as the dependence of biological effects on the wavelength of radiation, was found. Conclusions. The results obtained allow making a number of assumptions about the mechanisms of action of the optical electromagnetic waves on tumor growth, modulating free radical processes in the tumor-bearing organism.

scholarly journals Cold helium plasma as a modifier of free radical processes in the blood: in vitro study

2021 ◽  
Vol 8 (1) ◽  
pp. 34-40
Author(s):  
Andrew K. Martusevich ◽  
◽  
Alexander G. Galka ◽  
Konstantin A. Karuzin ◽  
Alexander N. Tuzhilkin ◽  
...  
Keyword(s):  
Free Radical ◽  
In Vitro Study ◽  
Vitro Study ◽  
Helium Plasma ◽  
Free Radical Processes ◽  
Radical Processes

Free radical processes induced by desiccation in germinating maize. The relationship with respiration and loss of desiccation tolerance

1994 ◽  
Vol 102 ◽  
pp. 211-218 ◽  
Author(s):  
O. Leprince ◽  
G. A. F. Hendry ◽  
N. M. Atherton
Keyword(s):  
Free Radical ◽  
Desiccation Tolerance ◽  
Respiratory Enzymes ◽  
Stable Free Radical ◽  
Paramagnetic Resonance ◽  
Free Radical Processes ◽  
Transport Chain ◽  
Resonance Response ◽  
Radical Processes

SynopsisUsing germination of maize as a model, desiccation-induced free radical processes were studied with the object of understanding desiccation tolerance. Several significant elements of damage were observed in desiccated material associated with development of desiccation intolerance: increased lipid peroxidation, phospholipid de-esterification, build-up of a stable free radical, supression or repression of respiratory enzymes from complex I, II and IV. An EPR (electron paramagnetic resonance) response was also detected in isolated mitochondria following in vitro desiccation. The loss of desiccation tolerance appeared to be dependent on oxygen concentration. Two highly significant correlations were independently found between respiration rates and production of a stable free radical detected by EPR. These data suggest that respiration is an important factor in the loss of desiccation tolerance. We present a model suggesting that activated oxygen formation during desiccation originates in the disruption of the mitochondrial electron transport chain with increasing leakage to oxygen so generating irreversible and lethal peroxidative damage, leading to the development of desiccation intolerance.

The Study of Free Radical Processes and Antioxidant Activity of Hybrid Composites with Hydroxyapatite on the Basis of Polystyrene In Vitro

10.12737/7285 ◽  
2014 ◽  
Vol 21 (4) ◽  
pp. 129-133
Author(s):  
Багровская ◽  
N. Bagrovskaya ◽  
Алексеева ◽  
O. Alekseeva ◽  
Назаров ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Free Radical ◽  
Blood Serum ◽  
Hybrid Composites ◽  
Malonic Dialdehyde ◽  
Total Blood ◽  
Free Radical Processes ◽  
Mechanical Dispersion ◽  
Radical Processes

The polystyrene composites, received by application polymeric solution (polystyrene) on teflon base sheet with the following samples drying at 293 K to constant mass were studied. The hydroxiapatite particles immobilization in polysterene matrix was made by mechanical dispersion. The polimeric’s systames hydroxiapatite concentration were 0,03; 0,1; 0,5 mac.%. The authors determined sorption and structural hydroxiapatite’s characteristics such as specific surface area and pore volume. The authors studied the influence of hydroxiapatite concentration in composites on lipid free radical processes and antioxidant activity of confluent blood serum and confluent serum after contact with composite, including hydroxiapatite in vitro. It was noted that polymeric composites with 0,1 and 0,5 mac% hydroxiapatite concentration increase the hemiluminescence parameters based on hemiluminescence analysis: fast flashes Imax and lightsum S. These data argue for free radical processes activation, so curve slope ratio increased tga and parameters A and Z decreased. It’s reflects the antioxidant activity increasing. The authors performed the investigation of malonic dialdehyde content and total blood serum antioxidant activity by spectrophotometry. The antioxidant activity increasing after composites impact, including 0.5mac% hydroxiapatite in confluent blood serum was determined. These data argue for composites’ antioxidant effects in comparison with control blood serum.

SCH 43478 and analogs: in vitro activity and in vivo efficacy of novel agents for herpesvirus type 2

1997 ◽  
Vol 35 (3) ◽  
pp. 139-146 ◽  
Author(s):  
Randi Albin ◽  
Robert Chase ◽  
Christine Risano ◽  
Melvin Lieberman ◽  
Eric Ferrari ◽  
...  
Keyword(s):  
Vitro Activity ◽  
Novel Agents ◽  
In Vitro Activity ◽  
In Vivo Efficacy ◽  
Herpesvirus Type

Synthesis and in Vitro Activity of Long-Chain 5‘-O-[(Alkoxycarbonyl)phosphinyl]-3‘-azido-3‘-deoxythymidines against Wild-Type and AZT- and Foscarnet-Resistant Strains of HIV-1

1997 ◽  
Vol 40 (16) ◽  
pp. 2482-2490 ◽  
Author(s):  
Andre Rosowsky ◽  
Hongning Fu ◽  
Niranjan Pai ◽  
John Mellors ◽  
Douglas D. Richman ◽  
...  
Keyword(s):  
Vitro Activity ◽  
In Vitro Activity ◽  
Wild Type ◽  
Resistant Strains ◽  
Hiv 1 ◽  
Long Chain

scholarly journals The Study of Influence of Silica and Polyethilene Glycols Organic-Inorganic Compounds on Free-Radical Processes in Vitro

2010 ◽  
Vol 01 (02) ◽  
pp. 69-74 ◽  
Author(s):  
Olga G. Sitnikova ◽  
Sergey B. Nazarov ◽  
Irina V. Shikhanova ◽  
Alexander V. Agafonov ◽  
Jean A. Dyuzhev ◽  
...  
Keyword(s):  
Free Radical ◽  
Inorganic Compounds ◽  
Free Radical Processes ◽  
Radical Processes
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