Effect of N-methyl substitution of the peptide bonds in luteinizing hormone-releasing hormone agonists

1993 ◽  
Vol 36 (3) ◽  
pp. 363-369 ◽  
Author(s):  
Fortuna Haviv ◽  
Timothy D. Fitzpatrick ◽  
Rolf E. Swenson ◽  
Charles J. Nichols ◽  
Nicholas A. Mort ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Peptide Bonds ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Methyl Substitution

EFFECT OF CORTISOL OR ADRENOCORTICOTROPHIN ON RELEASE OF LUTEINIZING HORMONE INDUCED BY LUTEINIZING HORMONE RELEASING HORMONE IN THE DAIRY HEIFER

1982 ◽  
Vol 92 (1) ◽  
pp. 141-146 ◽  
Author(s):  
R. L. MATTERI ◽  
G. P. MOBERG
Keyword(s):  
Luteinizing Hormone ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Dairy Heifers ◽  
Significant Difference ◽  
Significant Depression ◽  
Lh Rh ◽  
Lh Releasing Hormone ◽  
And Control ◽  
Slight Depression

During treatment with cortisol or ACTH, dairy heifers were given two doses of LH releasing hormone (LH-RH) spaced 1·5 h apart. Serum concentrations of cortisol and LH were monitored during each treatment. Treatment with both ACTH and cortisol raised plasma cortisol levels above the respective saline controls (P<0·001). Neither treatment affected basal LH concentrations. A slight depression in LH response was seen in the cortisol-treated animals after the first LH-RH injection, as shown by a statistically significant depression at three of the sample times. There was no significant difference between treated and control LH values after the second LH-RH administration. Treatment with ACTH resulted in significantly reduced LH values at all sample times after both injections of LH-RH.

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