Inhibition of Human Neutrophil Elastase with Peptidyl Electrophilic Ketones. 2. Orally Active PG-Val-Pro-Val Pentafluoroethyl Ketones

1994 ◽  
Vol 37 (26) ◽  
pp. 4538-4553 ◽  
Author(s):  
Michael R. Angelastro ◽  
Larry E. Baugh ◽  
Philippe Bey ◽  
Joseph P. Burkhart ◽  
Teng-Man Chen ◽  
...  
Keyword(s):  
Neutrophil Elastase ◽  
Human Neutrophil ◽  
Human Neutrophil Elastase ◽  
Orally Active

Discovery and Biological Activity of Orally Active Peptidyl Trifluoromethyl Ketone Inhibitors of Human Neutrophil Elastase

1997 ◽  
Vol 40 (12) ◽  
pp. 1876-1885 ◽  
Author(s):  
Philip D. Edwards ◽  
Donald W. Andisik ◽  
Craig A. Bryant ◽  
Barbara Ewing ◽  
Bruce Gomes ◽  
...  
Keyword(s):  
Biological Activity ◽  
Neutrophil Elastase ◽  
Human Neutrophil ◽  
Human Neutrophil Elastase ◽  
Orally Active

Design and Synthesis of New Orally Active Nonpeptidic Inhibitors of Human Neutrophil Elastase

2000 ◽  
Vol 43 (26) ◽  
pp. 4927-4929 ◽  
Author(s):  
Kazuyuki Ohmoto ◽  
Tetsuya Yamamoto ◽  
Toshihide Horiuchi ◽  
Hirotoshi Imanishi ◽  
Yoshihiko Odagaki ◽  
...  
Keyword(s):  
Neutrophil Elastase ◽  
Human Neutrophil ◽  
Human Neutrophil Elastase ◽  
Design And Synthesis ◽  
Orally Active

Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine- trans -lactams

2001 ◽  
Vol 11 (2) ◽  
pp. 243-246 ◽  
Author(s):  
Simon J.F Macdonald ◽  
Michael D Dowle ◽  
Lee A Harrison ◽  
Julie E Spooner ◽  
Pritom Shah ◽  
...  
Keyword(s):  
Neutrophil Elastase ◽  
Human Neutrophil ◽  
Human Neutrophil Elastase ◽  
Orally Active ◽  
Intracellular Inhibition

Corrigendum to “Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine-trans-lactams”

2001 ◽  
Vol 11 (9) ◽  
pp. 1249
Author(s):  
Simon J.F. Macdonald ◽  
Michael D. Dowle ◽  
Lee A. Harrison ◽  
Julie E. Spooner ◽  
Pritom Shah ◽  
...  
Keyword(s):  
Neutrophil Elastase ◽  
Human Neutrophil ◽  
Human Neutrophil Elastase ◽  
Orally Active ◽  
Intracellular Inhibition

Inhibition of Human Neutrophil Elastase. 3. An Orally Active Enol Acetate Prodrug

1995 ◽  
Vol 38 (2) ◽  
pp. 223-233 ◽  
Author(s):  
Joseph P. Burkhart ◽  
Jack R. Koehl ◽  
Shujaath Mehdi ◽  
Sherrie L. Durham ◽  
Michael J. Janusz ◽  
...  
Keyword(s):  
Neutrophil Elastase ◽  
Human Neutrophil ◽  
Human Neutrophil Elastase ◽  
Enol Acetate ◽  
Orally Active

Development of Orally Active Nonpeptidic Inhibitors of Human Neutrophil Elastase

2001 ◽  
Vol 44 (8) ◽  
pp. 1268-1285 ◽  
Author(s):  
Kazuyuki Ohmoto ◽  
Tetsuya Yamamoto ◽  
Motohiro Okuma ◽  
Toshihide Horiuchi ◽  
Hirotoshi Imanishi ◽  
...  
Keyword(s):  
Neutrophil Elastase ◽  
Human Neutrophil ◽  
Human Neutrophil Elastase ◽  
Orally Active
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