scholarly journals Structure-Activity Relationships of 1,3-Dialkylxanthine Derivatives at Rat A3 Adenosine Receptors

1994 ◽  
Vol 37 (20) ◽  
pp. 3373-3382 ◽  
Author(s):  
Hea Ok Kim ◽  
Xiao-duo Ji ◽  
Neli Melman ◽  
Mark E. Olah ◽  
Gary L. Stiles ◽  
...  
Keyword(s):  
Adenosine Receptors ◽  
Structure Activity Relationships ◽  
Structure Activity

scholarly journals Species differences in structure-activity relationships of adenosine agonists and xanthine antagonists at brain A1 adenosine receptors

FEBS Letters ◽  
1986 ◽  
Vol 209 (1) ◽  
pp. 122-128 ◽  
Author(s):  
Dieter Ukena ◽  
Kenneth A. Jacobson ◽  
William L. Padgett ◽  
Cristina Ayala ◽  
Mah T. Shamim ◽  
...  
Keyword(s):  
Adenosine Receptors ◽  
Species Differences ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Adenosine Agonists ◽  
A1 Adenosine Receptors

Adenosine receptors: synthesis, structure-activity relationships and biological activity of new 6-amino purine derivatives

1998 ◽  
Vol 33 (6) ◽  
pp. 501-508 ◽  
Author(s):  
Giovannella Strappaghetti ◽  
Stefano Corsano ◽  
Roberta Barbaro ◽  
Antonio Lucacchini ◽  
Gino Giannaccini ◽  
...  
Keyword(s):  
Biological Activity ◽  
Adenosine Receptors ◽  
Purine Derivatives ◽  
Structure Activity Relationships ◽  
Structure Activity

ChemInform Abstract: Adenosine Receptors: Synthesis, Structure-Activity Relationships and Biological Activity of New 6-Amino Purine Derivatives.

ChemInform ◽  
2010 ◽  
Vol 30 (3) ◽  
pp. no-no
Author(s):  
G. STRAPPAGHETTI ◽  
S. CORSANO ◽  
R. BARBARO ◽  
A. LUCACCHINI ◽  
G. GIANNACCINI ◽  
...  
Keyword(s):  
Biological Activity ◽  
Adenosine Receptors ◽  
Purine Derivatives ◽  
Structure Activity Relationships ◽  
Structure Activity

scholarly journals Selective Ligands for Rat A3 Adenosine Receptors: Structure-Activity Relationships of 1,3-Dialkylxanthine 7-Riboside Derivatives

1994 ◽  
Vol 37 (23) ◽  
pp. 4020-4030 ◽  
Author(s):  
Hea Ok Kim ◽  
Xiao-duo Ji ◽  
Neli Melman ◽  
Mark E. Olah ◽  
Gary L. Stiles ◽  
...  
Keyword(s):  
Adenosine Receptors ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Selective Ligands

Definition of subclasses of adenosine receptors associated with adenylate cyclase: interaction of adenosine analogs with inhibitory A1 receptors and stimulatory A2 receptors

1987 ◽  
Vol 65 (3) ◽  
pp. 365-376 ◽  
Author(s):  
Dieter Ukena ◽  
Ray A. Olsson ◽  
John W. Daly
Keyword(s):  
Adenylate Cyclase ◽  
Adenosine Receptors ◽  
Cell Types ◽  
Structural Heterogeneity ◽  
Human Platelets ◽  
Pharmacological Characterization ◽  
Structure Activity Relationships ◽  
Adenosine Analogs ◽  
Structure Activity ◽  
Definition Of

The structure–activity relationships of 63 adenosine analogs as agonists for the A1 adenosine receptors that mediate inhibition of adenylate cyclase activity in rat fat cells and for the A2 adenosine receptors that mediate stimulation of adenylate cyclase in rat pheochromocytoma PC12 cells and human platelets were determined. The lack of correspondence between the structure–activity relationships of these analogs at the A1 and A2 receptors appear definitive in terms of establishing the existence of A1 and A2 subclasses of adenosine receptors. However, significant differences in the agonist profiles at A2 receptors of platelet and PC12 indicate a certain degree of structural heterogeneity within the members of the A2 adenosine receptor subclass. Whether such differences are due to different species or different cell types is not known. A set of adenosine analogs, such as N6-cyclohexyl-, N6-R-, and S-1-phenyl-2- propyladenosines, 5′-N-ethylcarboxamidoadenosine and its N6-cyclohexyl derivative, 2-chloro- adenosine, and 2-phenylaminoadenosine, appear to represent a series of analogs useful for pharmacological characterization of A1 and A2 classes of adenosine receptors.

scholarly journals Caffeine Analogs: Structure-Activity Relationships at Adenosine Receptors

Pharmacology ◽  
1991 ◽  
Vol 42 (6) ◽  
pp. 309-321 ◽  
Author(s):  
John W. Daly ◽  
Izumi Hide ◽  
Christa E. Müller ◽  
Mah Shamim
Keyword(s):  
Adenosine Receptors ◽  
Structure Activity Relationships ◽  
Structure Activity
Sign in / Sign up

Export Citation Format

Share Document