Design, Synthesis and Evaluation of Substituted Triarylnipecotic Acid Derivatives as GABA Uptake Inhibitors: Identification of a Ligand with Moderate Affinity and Selectivity for the Cloned Human GABA Transporter GAT-3

1994 ◽  
Vol 37 (15) ◽  
pp. 2334-2342 ◽  
Author(s):  
T. G. Murali Dhar ◽  
Laurence A. Borden ◽  
Sriram Tyagarajan ◽  
Kelli E. Smith ◽  
Theresa A. Branchek ◽  
...  
Keyword(s):  
Gaba Uptake ◽  
Gaba Transporter ◽  
Design Synthesis ◽  
Uptake Inhibitors ◽  
Gaba Uptake Inhibitors

Design, synthesis and SAR studies of GABA uptake inhibitors derived from 2-substituted pyrrolidine-2-yl-acetic acids

2015 ◽  
Vol 23 (6) ◽  
pp. 1284-1306 ◽  
Author(s):  
Tobias Steffan ◽  
Thejavathi Renukappa-Gutke ◽  
Georg Höfner ◽  
Klaus T. Wanner
Keyword(s):  
Gaba Uptake ◽  
Design Synthesis ◽  
Sar Studies ◽  
Uptake Inhibitors ◽  
Gaba Uptake Inhibitors ◽  
Acetic Acids

Selective mGAT2 (BGT-1) GABA Uptake Inhibitors: Design, Synthesis, and Pharmacological Characterization

2013 ◽  
Vol 56 (5) ◽  
pp. 2160-2164 ◽  
Author(s):  
Stine B. Vogensen ◽  
Lars Jørgensen ◽  
Karsten K. Madsen ◽  
Nrupa Borkar ◽  
Petrine Wellendorph ◽  
...  
Keyword(s):  
Gaba Uptake ◽  
Pharmacological Characterization ◽  
Design Synthesis ◽  
Uptake Inhibitors ◽  
Gaba Uptake Inhibitors

Synthesis and Biochemical Studies of Spirocyclic Amino Acid Esters, Part 3 Activity of 2-Azaspiro[4.5]decane-6-carboxylates as GABA-Uptake Inhibitors

1996 ◽  
Vol 329 (3) ◽  
pp. 149-154 ◽  
Author(s):  
Wilhelm Fleischhacker ◽  
Silvia Lauritz ◽  
Ernst Urban ◽  
Peter Baumann ◽  
Helmut Bittiger
Keyword(s):  
Amino Acid ◽  
Gaba Uptake ◽  
Amino Acid Esters ◽  
Uptake Inhibitors ◽  
Biochemical Studies ◽  
Gaba Uptake Inhibitors ◽  
Acid Esters

GABA-A agonists and GABA uptake inhibitors: Structure-activity relationships

1990 ◽  
Vol 21 (3) ◽  
pp. 169-188 ◽  
Author(s):  
Erik Falch ◽  
Orla M. Larsson ◽  
Arne Schousboe ◽  
Povl Krogsgaard-Larsen
Keyword(s):  
Gaba Uptake ◽  
Gaba A ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Uptake Inhibitors ◽  
Gaba Uptake Inhibitors
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