Non-Peptide Fibrinogen Receptor Antagonists. 7. Design and Synthesis of a Potent, Orally Active Fibrinogen Receptor Antagonist

Mark E. Duggan; Adel M. Naylor-Olsen; James J. Perkins; Paul S. Anderson; Charles T.-C. Chang; Jacquelynn J. Cook; Robert J. Gould; Nathan C. Ihle; George D. Hartman

doi:10.1021/jm00017a017

Non-Peptide Fibrinogen Receptor Antagonists. 7. Design and Synthesis of a Potent, Orally Active Fibrinogen Receptor Antagonist

Journal of Medicinal Chemistry ◽

10.1021/jm00017a017 ◽

1995 ◽

Vol 38 (17) ◽

pp. 3332-3341 ◽

Cited By ~ 34

Author(s):

Mark E. Duggan ◽

Adel M. Naylor-Olsen ◽

James J. Perkins ◽

Paul S. Anderson ◽

Charles T.-C. Chang ◽

...

Keyword(s):

Receptor Antagonist ◽

Receptor Antagonists ◽

Design And Synthesis ◽

Fibrinogen Receptor ◽

Orally Active

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ChemInform Abstract: Non-Peptide Fibrinogen Receptor Antagonists. Part 7. Design and Synthesis of a Potent, Orally Active Fibrinogen Receptor Antagonist.

ChemInform ◽

10.1002/chin.199551163 ◽

2010 ◽

Vol 26 (51) ◽

pp. no-no

Author(s):

M. E. DUGGAN ◽

A. M. NAYLOR-OLSEN ◽

J. J. PERKINS ◽

P. S. ANDERSON ◽

C. T.-C. CHANG ◽

...

Keyword(s):

Receptor Antagonist ◽

Receptor Antagonists ◽

Design And Synthesis ◽

Fibrinogen Receptor ◽

Orally Active

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Non-Peptide Glycoprotein IIb/IIIa Inhibitors. 17. Design and Synthesis of Orally Active, Long-Acting Non-Peptide Fibrinogen Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm9608117 ◽

1997 ◽

Vol 40 (12) ◽

pp. 1779-1788 ◽

Cited By ~ 40

Author(s):

Benny C. Askew ◽

Rodney A. Bednar ◽

Bohumil Bednar ◽

David A. Claremon ◽

Jacquelynn J. Cook ◽

...

Keyword(s):

Receptor Antagonists ◽

Design And Synthesis ◽

Fibrinogen Receptor ◽

Long Acting ◽

Orally Active

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Design and synthesis of orally active fibrinogen receptor antagonists

Peptide Chemistry 1992 ◽

10.1007/978-94-011-1474-5_138 ◽

1993 ◽

pp. 471-473

Author(s):

Ruth F. Nutt

Keyword(s):

Receptor Antagonists ◽

Design And Synthesis ◽

Fibrinogen Receptor ◽

Orally Active

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ChemInform Abstract: From Peptides to Heterocyclic Peptide Mimetics - Design and Synthesis of an Orally Active Fibrinogen Receptor Antagonist for the Prevention of Thrombosis.

ChemInform ◽

10.1002/chin.199712190 ◽

2010 ◽

Vol 28 (12) ◽

pp. no-no

Author(s):

H. U. STILZ ◽

G. BECK ◽

B. JABLONKA ◽

M. JUST

Keyword(s):

Receptor Antagonist ◽

Peptide Mimetics ◽

Design And Synthesis ◽

Prevention Of Thrombosis ◽

Fibrinogen Receptor ◽

Orally Active

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Nonpeptide glycoprotein IIb/IIIa inhibitors. 13. design and synthesis of an orally active pyrazolopiperazinone nonpeptide fibrinogen receptor antagonist

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(97)00256-4 ◽

1997 ◽

Vol 7 (12) ◽

pp. 1531-1536 ◽

Cited By ~ 20

Author(s):

B.C. Askew ◽

C.J. McIntyre ◽

C.A. Hunt ◽

D.A. Claremon ◽

J.J. Baldwin ◽

...

Keyword(s):

Receptor Antagonist ◽

Design And Synthesis ◽

Fibrinogen Receptor ◽

Orally Active

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ChemInform Abstract: Nonpeptide Glycoprotein IIb/IIIa Inhibitors. Part 13. Design and Synthesis of an Orally Active Pyrazolopiperazinone Nonpeptide Fibrinogen Receptor Antagonist.

ChemInform ◽

10.1002/chin.199742197 ◽

2010 ◽

Vol 28 (42) ◽

pp. no-no

Author(s):

B. C. ASKEW ◽

C. J. MCINTYRE ◽

C. A. HUNT ◽

D. A. CLAREMON ◽

J. J. BALDWIN ◽

...

Keyword(s):

Receptor Antagonist ◽

Design And Synthesis ◽

Fibrinogen Receptor ◽

Orally Active

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ChemInform Abstract: Design and Synthesis of a Novel Class of Highly Potent Selective and Orally Active Non-peptide Bradykinin B2 Receptor Antagonists

ChemInform ◽

10.1002/chin.200004282 ◽

2010 ◽

Vol 31 (4) ◽

pp. no-no

Author(s):

Hiroshi Kayakiri ◽

Yoshito Abe ◽

Teruo Oku

Keyword(s):

Receptor Antagonists ◽

Bradykinin B2 Receptor ◽

Design And Synthesis ◽

Orally Active

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Conformationally tailored N-[(2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl)carbonyl]proline templates as molecular tools for the design of peptidomimetics. Design and synthesis of fibrinogen receptor antagonists

Organic & Biomolecular Chemistry ◽

10.1039/b400490f ◽

2004 ◽

Vol 2 (10) ◽

pp. 1511-1517 ◽

Cited By ~ 7

Author(s):

Petra Štefanič ◽

Zvone Simončič ◽

Matej Breznik ◽

Janez Plavec ◽

Marko Anderluh ◽

...

Keyword(s):

Molecular Tools ◽

Receptor Antagonists ◽

Design And Synthesis ◽

Fibrinogen Receptor

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Design of a New Class of Orally Active Fibrinogen Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm9801096 ◽

1998 ◽

Vol 41 (14) ◽

pp. 2492-2502 ◽

Cited By ~ 13

Author(s):

Scott I. Klein ◽

Bruce F. Molino ◽

Mark Czekaj ◽

Charles J. Gardner ◽

Valeria Chu ◽

...

Keyword(s):

Receptor Antagonists ◽

New Class ◽

Fibrinogen Receptor ◽

Orally Active

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Enantiospecific synthesis of SB 214857, a potent, orally active, nonpeptide fibrinogen receptor antagonist

Tetrahedron Letters ◽

10.1016/0040-4039(95)02054-3 ◽

1995 ◽

Vol 36 (52) ◽

pp. 9433-9436 ◽

Cited By ~ 34

Author(s):

William H. Miller ◽

Thomas W. Ku ◽

Fadia E. Ali ◽

William E. Bondinell ◽

Raul R. Calvo ◽

...

Keyword(s):

Receptor Antagonist ◽

Fibrinogen Receptor ◽

Enantiospecific Synthesis ◽

Orally Active

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