Synthesis of (Dialkylamino)alkyl-Disubstituted Pyrimido[5,6,1-de]acridines, a Novel Group of Anticancer Agents Active on a Multidrug Resistant Cell Line

1995 ◽  
Vol 38 (17) ◽  
pp. 3282-3286 ◽  
Author(s):  
Ippolito Antonini ◽  
Donatella Cola ◽  
Paolo Polucci ◽  
Maria Bontemps-Gracz ◽  
Edward Borowski ◽  
...  
Keyword(s):  
Cell Line ◽  
Anticancer Agents ◽  
Multidrug Resistant ◽  
Resistant Cell ◽  
Resistant Cell Line

scholarly journals Multidrug resistance in tumour cells: characterisation of the multidrug resistant cell line K562-Lucena 1

2001 ◽  
Vol 73 (1) ◽  
pp. 57-69 ◽  
Author(s):  
VIVIAN M. RUMJANEK ◽  
GILMA S. TRINDADE ◽  
KAREN WAGNER-SOUZA ◽  
MICHELE C. MELETTI-DE-OLIVEIRA ◽  
LUIS F. MARQUES-SANTOS ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Cell Line ◽  
Anticancer Agents ◽  
Vinca Alkaloid ◽  
Multidrug Resistant ◽  
Resistance Mechanisms ◽  
Resistant Cell ◽  
Cross Reactivity ◽  
Resistant Cell Line ◽  
P Glycoprotein

Multidrug resistance to chemotherapy is a major obstacle in the treatment of cancer patients. The best characterised mechanism responsible for multidrug resistance involves the expression of the MDR-1 gene product, P-glycoprotein. However, the resistance process is multifactorial. Studies of multidrug resistance mechanisms have relied on the analysis of cancer cell lines that have been selected and present cross-reactivity to a broad range of anticancer agents. This work characterises a multidrug resistant cell line, originally selected for resistance to the Vinca alkaloid vincristine and derived from the human erythroleukaemia cell K562. This cell line, named Lucena 1, overexpresses P-glycoprotein and have its resistance reversed by the chemosensitisers verapamil, trifluoperazine and cyclosporins A, D and G. Furthermore, we demonstrated that methylene blue was capable of partially reversing the resistance in this cell line. On the contrary, the use of 5-fluorouracil increased the resistance of Lucena 1. In addition to chemotherapics, Lucena 1 cells were resistant to ultraviolet A radiation and hydrogen peroxide and failed to mobilise intracellular calcium when thapsigargin was used. Changes in the cytoskeleton of this cell line were also observed.

Efficacy of Chemotherapeutic Agents Under Hypoxic Conditions in Pulmonary Adenocarcinoma Multidrug Resistant Cell Line

2007 ◽  
Vol 19 (2) ◽  
pp. 203-211 ◽  
Author(s):  
Shicang Yu ◽  
Guijun Huang ◽  
Guisheng Qian ◽  
Yuying Li ◽  
Guoming Wu ◽  
...  
Keyword(s):  
Cell Line ◽  
Multidrug Resistant ◽  
Resistant Cell ◽  
Chemotherapeutic Agents ◽  
Resistant Cell Line ◽  
Pulmonary Adenocarcinoma ◽  
Hypoxic Conditions

Interferon alfa 2b effect as chemosensitiser in a multidrug-resistant cell line

1999 ◽  
Vol 35 ◽  
pp. S197
Author(s):  
L. Rumi ◽  
M. Beviacqua ◽  
A. Sanchez ◽  
R. Bordenave ◽  
M.Lucero Gritti
Keyword(s):  
Cell Line ◽  
Multidrug Resistant ◽  
Resistant Cell ◽  
Resistant Cell Line ◽  
Interferon Alfa
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