9-Substituted acridine derivatives with long half-life and potent antitumor activity: synthesis and structure-activity relationships

Tsann-Long Su; Ting-Chao Chou; Joong Young Kim; Jai-Tung Huang; Grazyna Ciszewska; Wu-Yun Ren; Grenys M. Otter; Francis M. Sirotnak; Kyoichi A. Watanabe

doi:10.1021/jm00017a006

9-Substituted acridine derivatives with long half-life and potent antitumor activity: synthesis and structure-activity relationships

Journal of Medicinal Chemistry ◽

10.1021/jm00017a006 ◽

1995 ◽

Vol 38 (17) ◽

pp. 3226-3235 ◽

Cited By ~ 52

Author(s):

Tsann-Long Su ◽

Ting-Chao Chou ◽

Joong Young Kim ◽

Jai-Tung Huang ◽

Grazyna Ciszewska ◽

...

Keyword(s):

Antitumor Activity ◽

Half Life ◽

Structure Activity Relationships ◽

Acridine Derivatives ◽

Structure Activity

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ChemInform Abstract: 9-Substituted Acridine Derivatives with Long Half-Life and Potent Antitumor Activity: Synthesis and Structure-Activity Relationships.

ChemInform ◽

10.1002/chin.199551172 ◽

2010 ◽

Vol 26 (51) ◽

pp. no-no

Author(s):

T.-L. SU ◽

T.-C. CHOU ◽

J. Y. KIM ◽

J.-T. HUANG ◽

G. CISZEWSKA ◽

...

Keyword(s):

Antitumor Activity ◽

Half Life ◽

Structure Activity Relationships ◽

Acridine Derivatives ◽

Structure Activity

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2-[2‘-(Dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h]isoquinoline-1,3-diones with Substituents at Positions 4, 8, 9, 10, and 11. Synthesis, Antitumor Activity, and Quantitative Structure−Activity Relationships

Journal of Medicinal Chemistry ◽

10.1021/jm970322m ◽

1997 ◽

Vol 40 (16) ◽

pp. 2660-2660

Author(s):

Salah M. Sami ◽

Robert T. Dorr ◽

David S. Alberts ◽

Anikó M. Sólyom ◽

William A. Remers

Keyword(s):

Antitumor Activity ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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Structure-Activity Relationships of Synthetic Adrenocorticotropic Octadecapeptides with Special Reference to Biological Half-Life

Endocrinologia Japonica ◽

10.1507/endocrj1954.18.155 ◽

1971 ◽

Vol 18 (2) ◽

pp. 155-168 ◽

Cited By ~ 8

Author(s):

AKIRA TANAKA

Keyword(s):

Special Reference ◽

Half Life ◽

Structure Activity Relationships ◽

Structure Activity ◽

Biological Half Life

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ChemInform Abstract: Synthesis and Antitumor Activity of Tropolone Derivatives. Part 6. Structure-Activity Relationships of Antitumor-Active Tropolone and 8-Hydroxyquinoline Derivatives.

ChemInform ◽

10.1002/chin.198810234 ◽

1988 ◽

Vol 19 (10) ◽

Author(s):

M. YAMATO ◽

K. HASHIGAKI ◽

Y. YASUMOTO ◽

J. SAKAI ◽

R. F. LUDUENA ◽

...

Keyword(s):

Antitumor Activity ◽

Structure Activity Relationships ◽

Structure Activity

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Synthesis of hetero annulated isoxazolo-, pyrido- and pyrimido carbazoles: Screened for in vitro antitumor activity and structure activity relationships, a novel 2-amino-4-(3'-bromo-4'-methoxyphenyl)-8-chloro-11 H -pyrimido[4,5- a ]carbazole as an antitumor agent

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2017.02.009 ◽

2017 ◽

Vol 128 ◽

pp. 319-331 ◽

Cited By ~ 10

Author(s):

Karunanidhi Murali ◽

Hazel A. Sparkes ◽

Karnam Jayarampillai Rajendra Prasad

Keyword(s):

Antitumor Activity ◽

Antitumor Agent ◽

Structure Activity Relationships ◽

Structure Activity

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2-[2‘-(Dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h]isoquinoline-1,3-diones with Substituents at Positions 4, 8, 9, 10, and 11. Synthesis, Antitumor Activity, and Quantitative Structure−Activity Relationships

Journal of Medicinal Chemistry ◽

10.1021/jm960623g ◽

1996 ◽

Vol 39 (25) ◽

pp. 4978-4987 ◽

Cited By ~ 30

Author(s):

Salah M. Sami ◽

Robert T. Dorr ◽

David S. Alberts ◽

Anikó M. Sólyom ◽

William A. Remers

Keyword(s):

Antitumor Activity ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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Quantitative Structure Activity Relationships of Anthracycline Antitumor Activity and Cardiac Toxicity Based Upon Intercalation Calculations

The Jerusalem Symposia on Quantum Chemistry and Biochemistry - Intermolecular Forces ◽

10.1007/978-94-015-7658-1_27 ◽

1981 ◽

pp. 431-444 ◽

Cited By ~ 7

Author(s):

A. J. Hopfinger ◽

Y. Nakata ◽

N. Max

Keyword(s):

Antitumor Activity ◽

Cardiac Toxicity ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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Structure-activity relationships of cyclic enediynes related to dynemicin A—I. Synthesis and antitumor activity of 9-acetoxy enediynes equipped with aryl carbamate moieties

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(97)00026-6 ◽

1997 ◽

Vol 5 (5) ◽

pp. 883-901 ◽

Cited By ~ 6

Author(s):

Ryoichi Unno ◽

Hisashi Michishita ◽

Hideaki Inagaki ◽

Yoko Suzuki ◽

Yutaka Baba ◽

...

Keyword(s):

Antitumor Activity ◽

Structure Activity Relationships ◽

Structure Activity

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Structure-activity relationships of cyclic enediynes related to dynemicin A—II. Synthesis and antitumor activity of 9- and 12-substituted enediynes equipped with aryl carbamate moieties

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(97)00027-8 ◽

1997 ◽

Vol 5 (5) ◽

pp. 903-919 ◽

Cited By ~ 13

Author(s):

Ryoichi Unno ◽

Hisashi Michishita ◽

Hideaki Inagaki ◽

Yoko Suzuki ◽

Yutaka Baba ◽

...

Keyword(s):

Antitumor Activity ◽

Structure Activity Relationships ◽

Structure Activity

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Synthesis and antitumor activity of tropolone derivatives. 6. Structure-activity relationships of antitumor-active tropolone and 8-hydroxyquinoline derivatives

Journal of Medicinal Chemistry ◽

10.1021/jm00393a035 ◽

1987 ◽

Vol 30 (10) ◽

pp. 1897-1900 ◽

Cited By ~ 31

Author(s):

Masatoshi Yamato ◽

Kuniko Hashigaki ◽

Yoshiko Yasumoto ◽

Junko Sakai ◽

Richard F. Luduena ◽

...

Keyword(s):

Antitumor Activity ◽

Structure Activity Relationships ◽

Structure Activity

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