Use of .beta.-Methylphenylalanine (.beta.MeF) Residues To Probe the Nature of the Interaction of Substance P with Its Receptor: Effects of .beta.MeF-Containing Substance P Analogs on Rabbit Iris Smooth Muscle Contraction

1995 ◽  
Vol 38 (13) ◽  
pp. 2478-2482 ◽  
Author(s):  
David M. Birney ◽  
Derek C. Cole ◽  
Craig E. Crosson ◽  
Brenda F. Kahl ◽  
Bart W. Neff ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Substance P ◽  
Muscle Contraction ◽  
Smooth Muscle Contraction ◽  
Substance P Analogs ◽  
Rabbit Iris

Tracheal smooth muscle responses to substance P and neurokinin A in the piglet

1992 ◽  
Vol 72 (3) ◽  
pp. 1090-1095 ◽  
Author(s):  
B. Haxhiu-Poskurica ◽  
M. A. Haxhiu ◽  
G. K. Kumar ◽  
M. J. Miller ◽  
R. J. Martin
Keyword(s):  
Smooth Muscle ◽  
Substance P ◽  
Muscle Contraction ◽  
Muscle Tension ◽  
Age Groups ◽  
Smooth Muscle Contraction ◽  
Tracheal Smooth Muscle ◽  
Neurokinin A ◽  
Dose Dependent Increase ◽  
Dose Dependent

The tachykinins substance P (SP) and neurokinin A (NKA) have been shown to induce airway smooth muscle contraction in mature animals, and the enzyme neutral endopeptidase (NEP) modulates this effect. We evaluated maturation of SP- and NKA-induced tracheal smooth muscle contraction and modulation of their effects by NEP in anesthetized, paralyzed, and artificially ventilated piglets less than 4 days, 2–3 wk, and 10 wk of age. Tracheal smooth muscle tension was measured in vivo from an open tracheal segment by use of a force transducer. Intravenous SP caused a dose-dependent increase in tracheal tension in all three age groups; however, the response in less than 4-day-old piglets was significantly weaker than in 2- to 3- and 10-wk-old piglets. NKA caused a dose-dependent increase in tracheal tension only in 2- to 3- and 10-wk-old piglets. The response of tracheal tension to NKA was weaker than the response to SP in all age groups. Atropine (2 mg/kg) significantly diminished the responses of tracheal tension to SP and NKA, indicating a cholinergic contribution to these responses at all ages. Intravenous thiorphan, a known NEP inhibitor, potentiated the effects of SP only in 2- to 3- and 10-wk-old piglets and did not affect the response of tracheal tension to NKA at any age. Biochemical analyses demonstrated a significant increase in tracheal NEP activity in comparably aged piglets over the first 10 wk of life.(ABSTRACT TRUNCATED AT 250 WORDS)

New reduced peptide bond substance P agonists and antagonists: effects on smooth muscle contraction

1991 ◽  
Vol 203 (3) ◽  
pp. 353-357 ◽  
Author(s):  
Susan Zacharia ◽  
Wojciech J. Rossowski ◽  
Jiang Ning-Yi ◽  
Pavel Hrbas ◽  
Atilla Ertan ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Substance P ◽  
Muscle Contraction ◽  
Peptide Bond ◽  
Smooth Muscle Contraction
Sign in / Sign up

Export Citation Format

Share Document