Structure-Activity Relationships in the 8-Amino-6,7,8,9-tetrahydro-3H-benz[e]indole Ring System. Part 2: Effect of 8-Amino Nitrogen Substitution on Serotonin Receptor Binding and Pharmacology

1995 ◽  
Vol 38 (12) ◽  
pp. 2217-2230 ◽  
Author(s):  
Michael D. Ennis ◽  
Peter Stjernloef ◽  
Robert L. Hoffman ◽  
Nabil B. Ghazal ◽  
Martin W. Smith ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Serotonin Receptor ◽  
Amino Nitrogen ◽  
Ring System ◽  
Indole Ring ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
System Part ◽  
Serotonin Receptor Binding ◽  
Nitrogen Substitution

scholarly journals New Terpendole Congeners, Inhibitors of Sterol O-Acyltransferase, Produced by Volutella citrinella BF-0440

Molecules ◽  
2020 ◽  
Vol 25 (13) ◽  
pp. 3079
Author(s):  
Elyza Aiman Azizah Nur ◽  
Keisuke Kobayashi ◽  
Ai Amagai ◽  
Taichi Ohshiro ◽  
Hiroshi Tomoda
Keyword(s):  
Inhibitory Activity ◽  
2D Nmr ◽  
Culture Broth ◽  
Ring System ◽  
Indole Ring ◽  
Ring Systems ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Activity Structure

New terpendoles N-P (1–3) were isolated along with 8 structurally related known compounds including terpendoles and voluhemins from a culture broth of the fungus Volutella citrinella BF-0440. The structures of 1–3 were elucidated using various spectroscopic experiments including 1D- and 2D-NMR. All compounds 1–3 contained a common indole–diterpene backbone. Compounds 2 and 3 had 7 and 6 consecutive ring systems with an indole ring, respectively, whereas 1 had a unique indolinone plus 4 consecutive ring system. Compounds 2 and 3 inhibited both sterol O-acyltransferase 1 and 2 isozymes, but 1 lost the inhibitory activity. Structure–activity relationships of fungal indole–diterpene compounds are discussed.

An approach for serotonin depletion in pigs: Effects on serotonin receptor binding

Synapse ◽  
2010 ◽  
Vol 65 (2) ◽  
pp. 136-145 ◽  
Author(s):  
Anders Ettrup ◽  
Birgitte R. Kornum ◽  
Pia Weikop ◽  
Gitte M. Knudsen
Keyword(s):  
Receptor Binding ◽  
Serotonin Receptor ◽  
Serotonin Depletion ◽  
Serotonin Receptor Binding
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