Benzoic and Cinnamic Acid Derivatives as Antioxidants:  Structure−Activity Relation

1999 ◽  
Vol 47 (4) ◽  
pp. 1453-1459 ◽  
Author(s):  
Fausta Natella ◽  
Mirella Nardini ◽  
Maurizio Di Felice ◽  
Cristina Scaccini
Keyword(s):  
Cinnamic Acid ◽  
Cinnamic Acid Derivatives ◽  
Structure Activity

Trans-3-Phenyl-2-Propenoic Acid (Cinnamic Acid) Derivatives: Structure-Activity Relationship as Hepatoprotective Agents

2007 ◽  
Vol 3 (5) ◽  
pp. 475-479 ◽  
Author(s):  
Eduardo Fernandez-Martinez ◽  
Rosa Bobadilla ◽  
Martha Morales-Rios ◽  
Pablo Muriel ◽  
Victor Perez-Alvarez
Keyword(s):  
Cinnamic Acid ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Cinnamic Acid Derivatives ◽  
Structure Activity ◽  
Propenoic Acid ◽  
Hepatoprotective Agents

ChemInform Abstract: Structure-Activity Relationships of Novel Anti-Malarial Agents. Part 2. Cinnamic Acid Derivatives

ChemInform ◽  
2001 ◽  
Vol 32 (18) ◽  
pp. no-no
Author(s):  
Jochen Wiesner ◽  
Andreas Mitsch ◽  
Pia Wissner ◽  
Hassan Jomaa ◽  
Martin Schlitzer
Keyword(s):  
Cinnamic Acid ◽  
Cinnamic Acid Derivatives ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Abstract Structure

Structure-Activity Relationships of Cinnamic Acid Derivatives as Germination Inhibitor of the FernGleichenia Japonica

1996 ◽  
Vol 9 (1) ◽  
pp. 21-26 ◽  
Author(s):  
Yoshikazu Hiraga ◽  
Li Chen ◽  
Masashi Kurokawa ◽  
Shinji Ohta ◽  
Takayuki Suga ◽  
...  
Keyword(s):  
Cinnamic Acid ◽  
Cinnamic Acid Derivatives ◽  
Germination Inhibitor ◽  
Structure Activity Relationships ◽  
Structure Activity

scholarly journals Synthesis, applications and Structure-Activity Relationship (SAR) of cinnamic acid derivatives: a review

2021 ◽  
Vol 10 (1) ◽  
pp. e28010111691
Author(s):  
Saraliny Bezerra França ◽  
Paulo Ricardo dos Santos Correia ◽  
Ilton Barros Daltro de Castro ◽  
Edeildo Ferreira da Silva Júnior ◽  
Maria Ester de Sá Barreto Barros ◽  
...  
Keyword(s):  
Cinnamic Acid ◽  
Therapeutic Potential ◽  
Structure Activity Relationship ◽  
Bioactive Molecules ◽  
Activity Relationship ◽  
Cinnamic Acid Derivatives ◽  
Structure Activity ◽  
Synthetic Routes ◽  
Synthetic Methodologies ◽  
Pharmacologically Active

The article aims to analyze the progress of the evolution of cinnamic acid derivatives through a bibliographic review, describing the main synthetic routes in obtaining this class, as well as remarkable biological applications and application of the structure-activity relationship (SAR) as a strategy for design pharmacologically active molecules. The methodology used consists of reading and analyzing articles, whose approach is descriptive, with data being collected regarding the therapeutic potential of derivatives of cinnamic acid and its relationship with structural scaffolding, as well as the most widely used synthetic approaches. As a result, it was observed that cinnamic acid and its derivatives from natural sources can be synthesized in appreciable quantities with varied synthetic routes, as well as being candidates for therapeutic agents, since they have several therapeutic applications against diabetes, infectious and degenerative diseases, among others, in addition to presenting activity such as pest control, which has attracted the attention of academic and industrial researchers. These compounds are highly versatile since their activity is intrinsically associated with the mode of interaction between the structure and its molecular target. However, in nature they are obtained in small quantities, therefore, the development of new approaches of synthetic methodologies to obtain such compounds in substantial quantities and linked to medicinal chemistry can contribute to the development of very effective bioactive molecules in comparison with their precursors.

Structure–activity relationships of novel anti-malarial agents. Part 2: cinnamic acid derivatives

2001 ◽  
Vol 11 (3) ◽  
pp. 423-424 ◽  
Author(s):  
Jochen Wiesner ◽  
Andreas Mitsch ◽  
Pia Wißner ◽  
Hassan Jomaa ◽  
Martin Schlitzer
Keyword(s):  
Cinnamic Acid ◽  
Cinnamic Acid Derivatives ◽  
Structure Activity Relationships ◽  
Structure Activity

Structure–activity relationships of trans-cinnamic acid derivatives on α-glucosidase inhibition

2004 ◽  
Vol 14 (11) ◽  
pp. 2893-2896 ◽  
Author(s):  
Sirichai Adisakwattana ◽  
Kasem Sookkongwaree ◽  
Sophon Roengsumran ◽  
Amorn Petsom ◽  
Nattaya Ngamrojnavanich ◽  
...  
Keyword(s):  
Cinnamic Acid ◽  
Cinnamic Acid Derivatives ◽  
Structure Activity Relationships ◽  
Structure Activity
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