Effect of Hydroxytyrosol Found in Extra Virgin Olive Oil on Oxidative DNA Damage and on Low-Density Lipoprotein Oxidation

1998 ◽  
Vol 46 (12) ◽  
pp. 5181-5187 ◽  
Author(s):  
Okezie I. Aruoma ◽  
Monica Deiana ◽  
Andrew Jenner ◽  
Barry Halliwell ◽  
Harparkash Kaur ◽  
...  
Keyword(s):  
Dna Damage ◽  
Olive Oil ◽  
Oxidative Dna Damage ◽  
Low Density Lipoprotein ◽  
Virgin Olive Oil ◽  
Density Lipoprotein ◽  
Extra Virgin Olive Oil ◽  
Low Density ◽  
Lipoprotein Oxidation ◽  
Low Density Lipoprotein Oxidation

Effects of dietary virgin olive oil phenols on low density lipoprotein oxidation in hyperlipidemic patients

Lipids ◽  
2001 ◽  
Vol 36 (11) ◽  
pp. 1195-1202 ◽  
Author(s):  
Roberta Masella ◽  
Claudio Giovannini ◽  
Rosaria Varì ◽  
Roberta Di Benedetto ◽  
Ettore Coni ◽  
...  
Keyword(s):  
Olive Oil ◽  
Low Density Lipoprotein ◽  
Virgin Olive Oil ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Oxidation ◽  
Low Density Lipoprotein Oxidation

Protective effect of olive oil and its phenolic compounds against low density lipoprotein oxidation

Lipids ◽  
2000 ◽  
Vol 35 (6) ◽  
pp. 633-638 ◽  
Author(s):  
Montserrat Fitó ◽  
María Isabel Covas ◽  
Rosa M. Lamuela-Raventós ◽  
Joan Vila ◽  
Jaume Torrents ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Protective Effect ◽  
Olive Oil ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Oxidation ◽  
Low Density Lipoprotein Oxidation

Low density lipoprotein oxidation is inhibited in vitro by olive oil constituents

1995 ◽  
Vol 117 (1) ◽  
pp. 25-32 ◽  
Author(s):  
Francesco Visioli ◽  
Giorgio Bellomo ◽  
GianFranco Montedoro ◽  
Claudio Galli
Keyword(s):  
Olive Oil ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Oxidation ◽  
Low Density Lipoprotein Oxidation

scholarly journals Protective Effect of Lusianthridin on Hemin-Induced Low-Density Lipoprotein Oxidation

2021 ◽  
Vol 14 (6) ◽  
pp. 567
Author(s):  
Su Wutyi Thant ◽  
Noppawan Phumala Morales ◽  
Visarut Buranasudja ◽  
Boonchoo Sritularak ◽  
Rataya Luechapudiporn
Keyword(s):  
Foam Cell ◽  
Low Density Lipoprotein ◽  
Cell Formation ◽  
Density Lipoprotein ◽  
Foam Cell Formation ◽  
Raw 264.7 ◽  
Low Density ◽  
Lipoprotein Oxidation ◽  
Raw 264.7 Macrophage Cells ◽  
Low Density Lipoprotein Oxidation

Oxidation of low-density lipoprotein (LDL) plays a crucial role in the pathogenesis of atherosclerosis. Hemin (iron (III)-protoporphyrin IX) is a degradation product of hemoglobin that can be found in thalassemia patients. Hemin is a strong oxidant that can cause LDL oxidation and contributes to atherosclerosis in thalassemia patients. Lusianthridin from Dendrobium venustrum is a phenolic compound that possesses antioxidant activity. Hence, lusianthridin could be a promising compound to be used against hemin-induced oxidative stress. The major goal of this study is to evaluate the protective effect of lusianthridin on hemin-induced low-density lipoprotein oxidation (he-oxLDL). Here, various concentrations of lusianthridin (0.25, 0.5, 1, and 2 µM) were preincubated with LDL for 30 min, then 5 µM of hemin was added to initiate the oxidation, and oxidative parameters were measured at various times of incubation (0, 1, 3, 6, 12, 24 h). Lipid peroxidation of LDL was measured by thiobarbituric reactive substance (TBARs) assay and relative electrophoretic mobility (REM). The lipid composition of LDL was analyzed by using reverse-phase HPLC. Foam cell formation with he-oxLDL in RAW 264.7 macrophage cells was detected by Oil Red O staining. The results indicated that lusianthridin could inhibit TBARs formation, decrease REM, decrease oxidized lipid products, as well as preserve the level of cholesteryl arachidonate and cholesteryl linoleate. Moreover, He-oxLDL incubated with lusianthridin for 24 h can reduce the foam cell formation in RAW 264.7 macrophage cells. Taken together, lusianthridin could be a potential agent to be used to prevent atherosclerosis in thalassemia patients.

Low-density lipoprotein oxidation in essential hypertension

1993 ◽  
Vol 11 (10) ◽  
pp. 1103-1111 ◽  
Author(s):  
Elena Maggi ◽  
Eugenia Marchesi ◽  
Valentina Ravetta ◽  
Francesco Falaschi ◽  
Giorgio Finardi ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Oxidation ◽  
Low Density Lipoprotein Oxidation
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