Multivariate Curve Resolution of Spectrophotometric Data for the Determination of Artificial Food Colors

2008 ◽  
Vol 56 (14) ◽  
pp. 5463-5468 ◽  
Author(s):  
Dirk W. Lachenmeier ◽  
Waltraud Kessler
Keyword(s):  
Multivariate Curve Resolution ◽  
Curve Resolution ◽  
Artificial Food ◽  
Spectrophotometric Data ◽  
Artificial Food Colors ◽  
Food Colors

Diet and Hyperactivity: Is There a Relationship?

PEDIATRICS ◽  
1980 ◽  
Vol 66 (4) ◽  
pp. 521-525
Author(s):  
Fredrick J. Stare ◽  
Elizabeth M. Whelan ◽  
Margaret Sheridan
Keyword(s):  
Artificial Food ◽  
Treatment And Prevention ◽  
Noticeable Improvement ◽  
Hyperactive Children ◽  
The Subject ◽  
Artificial Food Colors ◽  
The Relationship ◽  
Food Colors ◽  
Popular Books

In 1973 Dr Ben Feingold, a California allergist, proposed that salicylates, artificial flavors, and artificial food colors are a cause of hyperactivity. Dr Feingold recommended a diet free of these substances as both treatment and prevention of the condition. He has published two popular books on the subject, Why Your Child Is Hyperactive (1974) and The Feingold Cookbook for Hyperactive Children (1979). Many parents have adopted the diet for their hyperactive children, and some have reported a noticeable improvement in their child's behavior when the diet was followed. In recent years a number of experiments have been carried out to evaluate the relationship between hyperactivity, salicylates, artificial food colors, and artificial flavors. The data indicate that the symptoms of the vast majority of cases of children labeled "hyperactive" are not related to additives in their diet.

scholarly journals Quantitative analysis and resolution of pharmaceuticals in the environment using multivariate curve resolution-alternating least squares (MCR-ALS)

2019 ◽  
Vol 69 (2) ◽  
pp. 217-231 ◽  
Author(s):  
Ahmed Mostafa ◽  
Heba Shaaban
Keyword(s):  
Least Squares ◽  
Water Samples ◽  
Alternating Least Squares ◽  
Multivariate Curve Resolution ◽  
Least Squares Regression ◽  
Environmental Matrices ◽  
Curve Resolution ◽  
Real Water Samples ◽  
Target Analytes ◽  
Spectrophotometric Data

Abstract The study presents the application of multivariate curve resolution alternating least squares (MCR-ALS) with a correlation constraint for simultaneous resolution and quantification of ketoprofen, naproxen, paracetamol and caffeine as target analytes and triclosan as an interfering component in different water samples using UV-Vis spectrophotometric data. A multivariate regression model using the partial least squares regression (PLSR) algorithm was developed and calculated. The MCR-ALS results were compared with the PLSR obtained results. Both models were validated on external sample sets and were applied to the analysis of real water samples. Both models showed comparable and satisfactory results with the relative error of prediction of real water samples in the range of 1.70–9.75 % and 1.64–9.43 % for MCR-ALS and PLSR, resp. The obtained results show the potential of MCR-ALS with correlation constraint to be applied for the determination of different pharmaceuticals in complex environmental matrices.

Relative Effects of Drugs and Diet on Hyperactive Behaviors: An Experimental Study

PEDIATRICS ◽  
1978 ◽  
Vol 61 (6) ◽  
pp. 811-817 ◽  
Author(s):  
J. Ivan Williams ◽  
Douglas M. Cram ◽  
Frances T. Tausig ◽  
Evelyn Webster
Keyword(s):  
Food Additives ◽  
Drug Effects ◽  
Teacher Ratings ◽  
Double Blind ◽  
Artificial Food ◽  
Hyperactive Behavior ◽  
Treatment Conditions ◽  
Hyperactive Children ◽  
Artificial Food Colors ◽  
Food Colors

In a test of Feingold's hypothesis that food additives trigger the hyperactive response, 26 hyperactive children were randomly assigned to treatment conditions whereby they were given active or placebo medications in combination with challenge cookies with artificial food colors or control cookies without the additives. The children were crossed over into each of the four treatment conditions and experimental procedures were employed, including double-blind assessments through the completion of behavior checklists, by teachers and parents. Stimulant medications were clearly more effective than diet in reducing hyperactive behavior. The parent ratings indicate strong drug effects and inconclusive diet effects. Drug effects are marked in teacher ratings as well. However, when the children were receiving placebos, their hyperactive behaviors in the classroom were greater when eating cookies with artificial colors than when eating cookies without artificial colors. According to the ratings, approximately seven children were no longer hyperactive. There is evidence to suggest that the behavior of three to eight children was diet-responsive, depending on the criteria used. There is evidence, particularly in teacher ratings, in support of Feingold's hypothesis if it is modified. Further research is required to specify which subtypes of hyperactive children respond to a diet free of artificial food colors.

Comparative study of partial least squares and multivariate curve resolution for simultaneous spectrophotometric determination of pharmaceuticals in environmental samples

RSC Advances ◽  
2015 ◽  
Vol 5 (86) ◽  
pp. 70017-70024 ◽  
Author(s):  
Hadi Parastar ◽  
Hamidreza Shaye
Keyword(s):  
Comparative Study ◽  
Least Squares ◽  
Simultaneous Determination ◽  
Partial Least Squares ◽  
Mefenamic Acid ◽  
Environmental Samples ◽  
Multivariate Curve Resolution ◽  
Curve Resolution ◽  
Target Analytes

The potentials of PLSR and MCR-ALS are evaluated for the simultaneous determination of diclofenac, naproxen, mefenamic acid and carbamazepine as target analytes and gemfibrozil as interference in synthetic and real environmental samples.

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