Metabolism of 2,4,5-trichlorophenoxyacetic acid. Evidence for amino acid conjugates in soybean callus tissue

1978 ◽  
Vol 26 (5) ◽  
pp. 1125-1128 ◽  
Author(s):  
Masood Arjmand ◽  
Robert H. Hamilton ◽  
Ralph O. Mumma
Keyword(s):  
Amino Acid ◽  
Callus Tissue ◽  
Amino Acid Conjugates ◽  
Soybean Callus ◽  
Trichlorophenoxyacetic Acid

Amino Acid Conjugates in 2,4-D Treated Soybean (Glycine max) and Red Oak (Quercus rubra)

Weed Science ◽  
1983 ◽  
Vol 31 (4) ◽  
pp. 537-542 ◽  
Author(s):  
Paul Zama ◽  
Ralph O. Mumma
Keyword(s):  
Glycine Max ◽  
Amino Acid ◽  
Callus Tissue ◽  
Quercus Rubra ◽  
Red Oak ◽  
Gas Liquid Chromatography ◽  
Butyl Ether ◽  
Amino Acid Conjugates ◽  
Amino Acid Conjugate ◽  
Soybean Plants

A modified analytical procedure involving gas-liquid chromatography was used to investigate the relative amounts of 2,4-D [(2,4-dichlorophenoxy)acetic acid] and two of its amino acid conjugate metabolites, 2,4-D-Asp [(2,4-dichlorophenoxy)acetylaspartic acid] and 2,4-D-Glu [(2,4-dichlorophenoxy)acetylglutamic acid], in soybean [Glycine max (L.) Merr. var. Amsoy] plants, soybean callus tissue and red oak (Quercus rubra L.) plants at 2, 4, and 10 days after application of either 2,4-D, its ester, or its salts. 2,4-D-Asp and 2,4-D-Glu were found as major metabolites in all soybean tissues analyzed and their amounts varied depending upon the days following treatment, the formulation of treatment, and the plant substrate (0.03 to 57 ppm for 2,4-D-Asp and 0.05 to 75 ppm for 2,4-D-Glu). The amount of amino acid conjugates peaked at 2 days after treatment of callus tissue and 4 days after treatment of soybean plants. Much higher amounts of these amino acid conjugates were obtained from soybean plants treated with the propylene glycol butyl ether ester of 2,4-D than plants treated with amine salts of 2,4-D. No amino acid conjugates were observed with red oak plants.

Biological properties of amino acid conjugates of 2,4,5-trichlorophenoxyacetic acid

1979 ◽  
Vol 27 (5) ◽  
pp. 1086-1088 ◽  
Author(s):  
Gayle H. Davidonis ◽  
Masood Arjmand ◽  
Robert H. Hamilton ◽  
Ralph O. Mumma
Keyword(s):  
Amino Acid ◽  
Biological Properties ◽  
Amino Acid Conjugates ◽  
Trichlorophenoxyacetic Acid

Fluoroquinolone-3-carboxamide Amino Acid Conjugates: Synthesis, Antibacterial Properties And Molecular Modeling Studies

2020 ◽  
Vol 17 (1) ◽  
pp. 71-84
Author(s):  
Riham M. Bokhtia ◽  
Siva S. Panda ◽  
Adel S. Girgis ◽  
Hitesh H. Honkanadavar ◽  
Tarek S. Ibrahim ◽  
...  
Keyword(s):  
Experimental Data ◽  
Antibacterial Activity ◽  
Amino Acid ◽  
Bacterial Infections ◽  
Antibacterial Agents ◽  
Antibacterial Properties ◽  
Computational Studies ◽  
Protecting Group ◽  
Amino Acid Conjugates ◽  
Molecular Modeling Studies

Background: Bacterial infections are considered as one of the major global health threats, so it is very essential to design and develop new antibacterial agents to overcome the drawbacks of existing antibacterial agents. Method: The aim of this work is to synthesize a series of new fluoroquinolone-3-carboxamide amino acid conjugates by molecular hybridization. We utilized benzotriazole chemistry to synthesize the desired hybrid conjugates. Result: All the conjugates were synthesized in good yields, characterized, evaluated for their antibacterial activity. The compounds were screened for their antibacterial activity using methods adapted from the Clinical and Laboratory Standards Institute. Synthesized conjugates were tested for activity against medically relevant pathogens; Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27856) Staphylococcus aureus (ATCC 25923) and Enterococcus faecalis (ATCC 19433). Conclusion: The observed antibacterial experimental data indicates the selectivity of our synthesized conjugates against E.Coli. The protecting group on amino acids decreases the antibacterial activity. The synthesized conjugates are non-toxic to the normal cell lines. The experimental data were supported by computational studies.

scholarly journals Nicotinamide riboside–amino acid conjugates that are stable to purine nucleoside phosphorylase

2020 ◽  
Vol 18 (15) ◽  
pp. 2877-2885
Author(s):  
Faisal Hayat ◽  
Marie E. Migaud
Keyword(s):  
Amino Acid ◽  
Acid Ester ◽  
Purine Nucleoside Phosphorylase ◽  
Amino Acid Ester ◽  
Purine Nucleoside ◽  
Nucleoside Phosphorylase ◽  
Amino Acid Conjugates ◽  
Nicotinamide Riboside

O5′ amino acid ester conjugates of nicotinamide riboside, generated via a reduced intermediate, are stable to purine nucleoside phosphorylase.

Synthesis and anti-phlogistic potency of some new non-proteinogenic amino acid conjugates of ?Diclofenac?

Amino Acids ◽  
1999 ◽  
Vol 16 (3-4) ◽  
pp. 425-440 ◽  
Author(s):  
M. H. Abo-Ghalia ◽  
A. M. Shalaby ◽  
W. I. El-Eraqi ◽  
H. M. Awad
Keyword(s):  
Amino Acid ◽  
Amino Acid Conjugates ◽  
Proteinogenic Amino Acid

Synthesis and evaluation of some amino acid conjugates of pirprofen

2013 ◽  
Vol 3 (3) ◽  
pp. 241-246 ◽  
Author(s):  
S.K. Sharma ◽  
C. Karthikeyan ◽  
N.S. Hari Narayana Moorthy ◽  
D.K. Jain ◽  
P. Trivedi
Keyword(s):  
Amino Acid ◽  
Amino Acid Conjugates

Pyranosyl Sugar Amino Acid Conjugates

2001 ◽  
pp. 493-534 ◽  
Author(s):  
Jacquelyn Gervay-Hague ◽  
Thomas Weathers Jr
Keyword(s):  
Amino Acid ◽  
Amino Acid Conjugates
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