Effect of vitamin B12 and folic acid on utilization by rats of soybean protein and amino acids

1967 ◽  
Vol 15 (3) ◽  
pp. 444-447
Author(s):  
Yet-Oy. Chang ◽  
Fumi. Yokota
Keyword(s):  
Amino Acids ◽  
Folic Acid ◽  
Vitamin B12 ◽  
Soybean Protein

scholarly journals Experimental Production of Nutritional Macrocytic Anemia in Swine

Blood ◽  
1952 ◽  
Vol 7 (10) ◽  
pp. 992-1004 ◽  
Author(s):  
G. E. CARTWRIGHT ◽  
BETTY TATTING ◽  
DORIS KURTH ◽  
M. M. WINTROBE
Keyword(s):  
Bone Marrow ◽  
Folic Acid ◽  
Vitamin B12 ◽  
Soybean Protein ◽  
Macrocytic Anemia ◽  
Experimental Production ◽  
Vitamin Supplement ◽  
Normal Limits ◽  
Erythroid Hyperplasia ◽  
Pteroylglutamic Acid

Abstract A total of 20 swine were fed a diet adequate in all known respects except that soybean protein was substituted for casein, succinylsulfathiazole and a folic acid antagonist were added, and vitamin B12 and pteroylglutamic acid were withheld from the vitamin supplement. The animals developed macrocytic anemia, leukopenia and neutropenia, accompanied by erythroid hyperplasia of the bone marrow. Tue erythroblasts consisted mainly of immature macronormoblasts but a few atypical megaloblasts were also observed. The anemia responded rapidly and completely to the administration of both vitamin B12 and pteroylglutamic acid. The administration of pteroylglutamic acid alone resulted in an immediate return of the blood and bone marrow to within normal limits but after several months there was a partial hematologic relapse in spite of continued therapy with this vitamin. The administration of vitamin B12 alone resulted in only partial remission of the anemia and the bone marrow remained macronormoblastic although the megaloblasts tended to disappear. Growth of the animals was stimulated by the administration of either vitamin but the administration of both vitamins simultanseously resulted in the greatest rate of growth. No manifestations of neurologic disturbances or of inscreased pigment excretion were observed in the deficient swine.

Serum levels of folic acid, vitamin B12, and iron in anemia of pregnancy

1966 ◽  
Vol 96 (3) ◽  
pp. 310-315 ◽  
Author(s):  
Fred Benjamin ◽  
Frank A. Bassen ◽  
Leo M. Meyer
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Serum Levels
Sign in / Sign up

Export Citation Format

Share Document