Citral in Flavoring Extracts, Determination of Citral in Food and Drug Products in the Barbituric Acid Condensation Method

1962 ◽  
Vol 10 (1) ◽  
pp. 49-51 ◽  
Author(s):  
Leo Levi
Keyword(s):  
Barbituric Acid ◽  
Drug Products ◽  
Condensation Method

Determination of Citral in Essential Oils by the Barbituric Acid Condensation Method

1962 ◽  
Vol 45 (2) ◽  
pp. 475-502 ◽  
Author(s):  
J M Airth ◽  
B Stringer ◽  
W Skakum ◽  
Leo Levi
Keyword(s):  
Essential Oils ◽  
Barbituric Acid ◽  
Condensation Method

Quantitative Analysis of 5-Hydroxymethylfurfural in Linezolid Injection by High Performance Liquid Chromatography

2020 ◽  
Vol 16 (8) ◽  
pp. 1059-1067
Author(s):  
Jéssica Maurício Batista ◽  
Christian Fernandes
Keyword(s):  
High Performance ◽  
Potassium Phosphate ◽  
Gradient Elution ◽  
High Performance Liquid Chromatographic ◽  
Official Method ◽  
Ph Variation ◽  
Drug Products ◽  
Liquid Chromatographic Method ◽  
Liquid Chromatographic

Background: Linezolid is a synthetic broad-spectrum antibacterial belonging to the class of oxazolidinones. Linezolid for intravenous infusion is isotonized with dextrose. In acidic environment, the dehydration of dextrose produces furan derivatives, 5-hydroxymethylfurfural (5-HMF) being the main one. The determination of this degradation product is of fundamental importance, since there is evidence it is cytotoxic, genotoxic, mutagenic and carcinogenic. However, there is no official method for the determination of 5-HMF in drug products. Objective: The aim of this study was to develop and validate a high performance liquid chromatographic method to quantify 5-HMF in injection of linezolid. Methods: The chromatographic separation, after optimization, was performed on C18 (150 x 4.6 mm, 5 μm) column. Mobile phase was composed of 14 mM potassium phosphate buffer pH 3.0 ([H+] = 1.0 x 10-3) and methanol in gradient elution at 1.0 mL min-1. The injection volume was 10 μL and detection was performed at 285 nm. Results: The method was optimized and validated, showing selectivity, linearity in the range from 0.075 to 9.0 μg mL-1, precision (RSD ≤ 2.0%), accuracy (mean recovery of 100.07%) and robustness for temperature and pH variation. Conclusion: The method was shown to be adequate to determine 5-HMF in injection containing linezolid in routine analysis.

scholarly journals Determination of Socle Series using the Condensation Method

2001 ◽  
Vol 31 (1-2) ◽  
pp. 163-178 ◽  
Author(s):  
Klaus Lux ◽  
Markus Wiegelmann
Keyword(s):  
Condensation Method

Higher Yield and Quality through Particle Identification

2008 ◽  
Vol 51 (2) ◽  
pp. 55-65
Author(s):  
O. Valet ◽  
M. Lankers
Keyword(s):  
Rapid Determination ◽  
Particle Identification ◽  
Manufacturing Processes ◽  
Data Sets ◽  
Drug Products ◽  
Particulate Contamination ◽  
Yield And Quality ◽  
Analytical Result ◽  
Nasal Drug Products

The sources of particulate contamination are often not easy to identify. To control manufacturing processes, the measurement of particle concentration and size is necessary and has been routinely performed for many years. Technology has been developed to increase the information available for the immediate evaluation of particles. The method analyzes airborne particles or particles isolated from liquids automatically according to their number, size, and chemical composition.1,2 The analysis of thousands of particles enables users to locate the major sources of contamination in various manufacturing processes. The analytical tool provides rapid determination of particulate contamination, thus allowing for a quick, efficient response. Over time, the ability to compare analytical result data sets assists in detecting trends and implementing the appropriate quality management. Routine use of the technology contributes to ongoing supervision and optimization of production processes. This study reports on the use of the technology to analyze foreign particles associated with oral, inhalable, and nasal drug products (OINDP), parenterals, and coronary stents. Applications for troubleshooting and identifying latent contamination sources are discussed through several examples.

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