6-Shogaol, an Active Constituent of Dietary Ginger, Impairs Cancer Development and Lung Metastasis by Inhibiting the Secretion of CC-Chemokine Ligand 2 (CCL2) in Tumor-Associated Dendritic Cells

2015 ◽  
Vol 63 (6) ◽  
pp. 1730-1738 ◽  
Author(s):  
Ya-Ling Hsu ◽  
Jen-Yu Hung ◽  
Ying-Ming Tsai ◽  
Eing-Mei Tsai ◽  
Ming-Shyan Huang ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Lung Metastasis ◽  
Cancer Development ◽  
Active Constituent ◽  
Cc Chemokine ◽  
Chemokine Ligand ◽  
Cc Chemokine Ligand 2 ◽  
Chemokine Ligand 2

CC chemokine ligand 2 down-modulation by selected Toll-like receptor agonist combinations contributes to T helper 1 polarization in human dendritic cells

Blood ◽  
2009 ◽  
Vol 114 (4) ◽  
pp. 796-806 ◽  
Author(s):  
Manuela Del Cornò ◽  
Alessandro Michienzi ◽  
Andrea Masotti ◽  
Letizia Da Sacco ◽  
Gian Franco Bottazzo ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Interleukin 12 ◽  
Toll Like Receptor ◽  
T Helper ◽  
Cc Chemokine ◽  
Chemokine Ligand ◽  
Cc Chemokine Ligand 2 ◽  
Chemokine Ligand 2 ◽  
Helper Type

Abstract Toll-like receptor (TLR) signaling activation by pathogens is critical to the induction of immune responses, and demands tight regulation. We describe in this study that CC chemokine ligand 2 (CCL2) secretion triggered by TLR4 or TLR8 engagement is strongly inhibited upon simultaneous activation of both TLRs in human monocyte-derived dendritic cells (DCs). Impaired CCL2 secretion occurs concomitantly to interleukin-12 up-regulation, being part of a complex regulatory circuit ensuring optimal T helper type 1 polarization. Interestingly, triggering selected TLRs or their combinations differently affects nuclear factor-κB p65 activation and microRNA expression. Overall, these results indicate that CCL2 supplies an important immunomodulatory role to DCs, and may contribute to dictate the cytokine profile in T helper type 1 responses induced by DCs.

scholarly journals Macrophage Migration Inhibitory Factor Induces Macrophage Recruitment via CC Chemokine Ligand 2

2006 ◽  
Vol 177 (11) ◽  
pp. 8072-8079 ◽  
Author(s):  
Julia L. Gregory ◽  
Eric F. Morand ◽  
Sonja J. McKeown ◽  
Jennifer A. Ralph ◽  
Pamela Hall ◽  
...  
Keyword(s):  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Cc Chemokine ◽  
Macrophage Recruitment ◽  
Chemokine Ligand ◽  
Cc Chemokine Ligand 2 ◽  
Chemokine Ligand 2

scholarly journals The prostaglandin E2 receptor EP3 controls CC-chemokine ligand 2–mediated neuropathic pain induced by mechanical nerve damage

2018 ◽  
Vol 293 (25) ◽  
pp. 9685-9695 ◽  
Author(s):  
Elsa-Marie Treutlein ◽  
Katharina Kern ◽  
Andreas Weigert ◽  
Neda Tarighi ◽  
Claus-Dieter Schuh ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Prostaglandin E2 ◽  
Nerve Damage ◽  
Cc Chemokine ◽  
Chemokine Ligand ◽  
Prostaglandin E2 Receptor ◽  
Cc Chemokine Ligand 2 ◽  
Chemokine Ligand 2

scholarly journals The CC Chemokine Ligand 2 (CCL2) Mediates Fibroblast Survival through IL-6

2007 ◽  
Vol 37 (1) ◽  
pp. 121-128 ◽  
Author(s):  
Xiangde Liu ◽  
Anuk M. Das ◽  
Jonathan Seideman ◽  
Don Griswold ◽  
Chantal N. Afuh ◽  
...  
Keyword(s):  
Cc Chemokine ◽  
Chemokine Ligand ◽  
Cc Chemokine Ligand 2 ◽  
Chemokine Ligand 2

scholarly journals Deficiency of CC chemokine ligand 2 and decay-accelerating factor causes retinal degeneration in mice

2015 ◽  
Vol 138 ◽  
pp. 126-133 ◽  
Author(s):  
Minzhong Yu ◽  
Kai Kang ◽  
Ping Bu ◽  
Brent A. Bell ◽  
Charles Kaul ◽  
...  
Keyword(s):  
Retinal Degeneration ◽  
Decay Accelerating Factor ◽  
Cc Chemokine ◽  
Chemokine Ligand ◽  
Cc Chemokine Ligand 2 ◽  
Chemokine Ligand 2

scholarly journals Differential Roles of CC Chemokine Ligand 2/Monocyte Chemotactic Protein-1 and CCR2 in the Development of T1 Immunity

2002 ◽  
Vol 168 (9) ◽  
pp. 4659-4666 ◽  
Author(s):  
Tim R. Traynor ◽  
Amy C. Herring ◽  
Martin E. Dorf ◽  
William A. Kuziel ◽  
Galen B. Toews ◽  
...  
Keyword(s):  
Cc Chemokine ◽  
Monocyte Chemotactic Protein ◽  
Chemotactic Protein ◽  
Chemokine Ligand ◽  
Cc Chemokine Ligand 2 ◽  
Chemokine Ligand 2

CC Chemokine Ligand 2 and Leukemia Inhibitory Factor Cooperatively Promote Pluripotency in Mouse Induced Pluripotent Cells

Stem Cells ◽  
2011 ◽  
Vol 29 (8) ◽  
pp. 1196-1205 ◽  
Author(s):  
Yuki Hasegawa ◽  
Naoko Takahashi ◽  
Alistair R. R. Forrest ◽  
Jay W. Shin ◽  
Yohei Kinoshita ◽  
...  
Keyword(s):  
Leukemia Inhibitory Factor ◽  
Inhibitory Factor ◽  
Pluripotent Cells ◽  
Cc Chemokine ◽  
Induced Pluripotent Cells ◽  
Chemokine Ligand ◽  
Induced Pluripotent ◽  
Cc Chemokine Ligand 2 ◽  
Chemokine Ligand 2

scholarly journals Affinity of Carlumab for CC-Chemokine Ligand 2 (CCL2) in Neat Human Sera

2017 ◽  
Vol 2 (1) ◽  
Author(s):  
Lacy ER ◽  
Kwok D ◽  
Baker A ◽  
Seetharam S ◽  
Chaturvedi S ◽  
...  
Keyword(s):  
Cc Chemokine ◽  
Chemokine Ligand ◽  
Human Sera ◽  
Cc Chemokine Ligand 2 ◽  
Chemokine Ligand 2
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