Hibiscus sabdariffa Polyphenols Alleviate Insulin Resistance and Renal Epithelial to Mesenchymal Transition: A Novel Action Mechanism Mediated by Type 4 Dipeptidyl Peptidase

2014 ◽  
Vol 62 (40) ◽  
pp. 9736-9743 ◽  
Author(s):  
Chiung-Huei Peng ◽  
Yi-Sun Yang ◽  
Kuei-Chuan Chan ◽  
Chau-Jong Wang ◽  
Mu-Lin Chen ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Epithelial To Mesenchymal Transition ◽  
Dipeptidyl Peptidase ◽  
Hibiscus Sabdariffa ◽  
Action Mechanism ◽  
Mesenchymal Transition

Hibiscus sabdariffa polyphenols prevent palmitate-induced renal epithelial mesenchymal transition by alleviating dipeptidyl peptidase-4-mediated insulin resistance

2016 ◽  
Vol 7 (1) ◽  
pp. 475-482 ◽  
Author(s):  
Chien-Ning Huang ◽  
Chau-Jong Wang ◽  
Yi-Sun Yang ◽  
Chih-Li Lin ◽  
Chiung-Huei Peng
Keyword(s):  
Insulin Resistance ◽  
Diabetic Nephropathy ◽  
Epithelial Mesenchymal Transition ◽  
Dipeptidyl Peptidase ◽  
Socioeconomic Impact ◽  
Hibiscus Sabdariffa ◽  
Mesenchymal Transition ◽  
Dipeptidyl Peptidase 4

Diabetic nephropathy has a significant socioeconomic impact, but its mechanism is unclear and needs to be examined.

The role of DUBs in the post-translational control of cell migration

2019 ◽  
Vol 63 (5) ◽  
pp. 579-594 ◽  
Author(s):  
Guillem Lambies ◽  
Antonio García de Herreros ◽  
Víctor M. Díaz
Keyword(s):  
Cell Migration ◽  
Translational Control ◽  
Epithelial To Mesenchymal Transition ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Mesenchymal Transition ◽  
Tgfβ Receptors ◽  
Fundamental Process ◽  
Multistep Process

Abstract Cell migration is a multifactorial/multistep process that requires the concerted action of growth and transcriptional factors, motor proteins, extracellular matrix remodeling and proteases. In this review, we focus on the role of transcription factors modulating Epithelial-to-Mesenchymal Transition (EMT-TFs), a fundamental process supporting both physiological and pathological cell migration. These EMT-TFs (Snail1/2, Twist1/2 and Zeb1/2) are labile proteins which should be stabilized to initiate EMT and provide full migratory and invasive properties. We present here a family of enzymes, the deubiquitinases (DUBs) which have a crucial role in counteracting polyubiquitination and proteasomal degradation of EMT-TFs after their induction by TGFβ, inflammatory cytokines and hypoxia. We also describe the DUBs promoting the stabilization of Smads, TGFβ receptors and other key proteins involved in transduction pathways controlling EMT.

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