Identification of the Environmental Neurotoxins Annonaceous Acetogenins in an Annona cherimolia Mill. Alcoholic Beverage Using HPLC-ESI-LTQ-Orbitrap

2014 ◽  
Vol 62 (34) ◽  
pp. 8696-8704 ◽  
Author(s):  
Jessica Le Ven ◽  
Isabelle Schmitz-Afonso ◽  
Guy Lewin ◽  
Alain Brunelle ◽  
David Touboul ◽  
...  
2010 ◽  
Vol 5 (3) ◽  
pp. 1934578X1000500 ◽  
Author(s):  
Olga Álvarez Colom ◽  
Analia Salvatore ◽  
Eduardo Willink ◽  
Roxana Ordóñez ◽  
María I. Isla ◽  
...  

Annonaceous acetogenins represent a class of bioactive compounds whose primary mode of action is the inhibition of NADH-ubiquinone oxidoreductase (Mitochondrial Complex I). Given the potential pesticidal use of these compounds, we evaluated the effects of seven acetogenins: squamocin (1), molvizarin (2), itrabin (3), almuñequin (4), cherimolin-1 (5), cherimolin-2 (6), and tucumanin (7) isolated from Annona cherimolia Mill. against Ceratitis capitata Wiedemann (Tephritidae). These acetogenins did not display insecticidal action at 250 μg of treatment per g of adult diet. However, the oviposition capacity of C. capitata females was significantly altered by some of the acetogenins at this concentration. The most potent compounds were itrabin, molvizarin and squamocin. Moreover, significant differences were detected in the preference of oviposition sites when itrabin and squamocin were spread on the surface of artificial fruits at doses of 30 μg/cm2. Additionally, we investigated the mutagenic effects displayed by itrabin, as well as the phytotoxic and genotoxic action of squamocin and itrabin. Both compounds displayed slight phytotoxic and genotoxic effects on roots of Allium cepa at 2.5 μg/mL though no mutagenic effects were detected at 0.25, 0.5 and 2.5 μg/mL on Salmonella typhimurium strains TA98 and TA100.


Fruits ◽  
2016 ◽  
Vol 71 (4) ◽  
pp. 215-220 ◽  
Author(s):  
Elisa Alonso González ◽  
Ignacio Orriols Fernández ◽  
Lorenzo Pastrana Castro ◽  
Nelson Pérez Guerra
Keyword(s):  

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
SD Ubaldo ◽  
EAG Araujo ◽  
VI Ledesma ◽  
R Estrada-Reyes ◽  
EAR Gonzalez ◽  
...  

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
J Le Ven ◽  
I Schmitz-Afonso ◽  
G Lewin ◽  
O Laprévote ◽  
A Brunelle ◽  
...  

1956 ◽  
Vol 17 (4) ◽  
pp. 629-632
Author(s):  
Deció Parreiras ◽  
Giorgio Lolli ◽  
Grace M. Golder
Keyword(s):  

1958 ◽  
Vol 19 (2) ◽  
pp. 303-308 ◽  
Author(s):  
Giorgio Lolli ◽  
Grace M. Golder ◽  
Emidio Serianni ◽  
Giovanni Bonfiglio ◽  
Claudia Balboni
Keyword(s):  

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