Osthole Inhibits Insulin-like Growth Factor-1-Induced Epithelial to Mesenchymal Transition via the Inhibition of PI3K/Akt Signaling Pathway in Human Brain Cancer Cells

2014 ◽  
Vol 62 (22) ◽  
pp. 5061-5071 ◽  
Author(s):  
Ying-Chao Lin ◽  
Jia-Ching Lin ◽  
Chao-Ming Hung ◽  
Yeh Chen ◽  
Liang-Chih Liu ◽  
...  
Keyword(s):  
Growth Factor ◽  
Human Brain ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Brain Cancer ◽  
Epithelial To Mesenchymal Transition ◽  
Akt Signaling ◽  
Insulin Like Growth Factor ◽  
Akt Signaling Pathway ◽  
Mesenchymal Transition

scholarly journals miR-193a Directly Targets PSEN1 and Inhibits Gastric Cancer Cell Growth, the Activation of PI3K/Akt Signaling Pathway, and the Epithelial-to-Mesenchymal Transition

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Xuemei Pan ◽  
Ting Zhao ◽  
Saisai Mu ◽  
Shouchuan Li
Keyword(s):  
Gastric Cancer ◽  
Overall Survival ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Epithelial To Mesenchymal Transition ◽  
Akt Signaling ◽  
Luciferase Reporter ◽  
Akt Signaling Pathway ◽  
Gastric Cancer Cells ◽  
Mesenchymal Transition

Background. Gastric cancer, a kind of gastrointestinal malignancy, is the second type of leading death cancer. miR-193a is a key tumor suppressor in several diseases. PSEN1 is mainly related to Alzheimer’s disease and may be involved in the cleavage of the Notch receptor. Material and Methods. RT-PCR and western blot were applied to evaluate miR-193a and the expression level of PSEN1. Luciferase reporter assay was applied to verify whether PSEN1 was a target of miR-193a. The Kaplan–Meier method was employed to calculate the 5-year overall survival of gastric cancer patients. Results. miR-193a was downregulated in gastric cancer tissues and cell lines, and downregulation of miR-193a predicted poor 5-year overall survival of gastric cancer. miR-193a inhibited the proliferation and the activation of the PI3K/AKT signaling pathway in gastric cancer cells. miR-193a inhibited gastric cancer tumor growth in vivo. miR-193a impaired cell invasion and epithelial-to-mesenchymal transition (EMT) in HGC-27 cells. In addition, PSEN1 was a direct target of miR-193a and PSEN1 reversed partial functions of miR-193a in cell proliferation and invasion. Conclusion. miR-193a prominently decreased the proliferation, invasion, and activation of the PI3K/Akt signaling pathway and the abilities of epithelial-to-mesenchymal transition in gastric cancer cells. The newly identified miR-193a/PSEN1 axis provides novel insight into the pathogenesis of gastric cancer.

Insulin-like growth factor-1 induces the phosphorylation of PRAS40 via the PI3K/Akt signaling pathway in PC12 cells

2012 ◽  
Vol 516 (1) ◽  
pp. 105-109 ◽  
Author(s):  
Haitao Wang ◽  
Qishan Zhang ◽  
Lang Zhang ◽  
Peter J. Little ◽  
Xiaochun Xie ◽  
...  
Keyword(s):  
Growth Factor ◽  
Signaling Pathway ◽  
Pc12 Cells ◽  
Akt Signaling ◽  
Insulin Like Growth Factor ◽  
Akt Signaling Pathway
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