Pharmacokinetics and Safety of Resveratrol Derivatives in Humans after Oral Administration of Melinjo (Gnetum gnemon L.) Seed Extract Powder

2014 ◽  
Vol 62 (8) ◽  
pp. 1999-2007 ◽  
Author(s):  
Hiroko Tani ◽  
Susumu Hikami ◽  
Sanae Iizuna ◽  
Maiko Yoshimatsu ◽  
Takashi Asama ◽  
...  
Keyword(s):  
Oral Administration ◽  
Seed Extract ◽  
Gnetum Gnemon ◽  
Resveratrol Derivatives

Potential of Gnetum gnemon L. Seed Extract Against Insulin Levels and PDX-1 Expression in Diabetes Mellitus Rats Model

2021 ◽  
Author(s):  
Rosni Rosni ◽  
I Nyoman Ehrich Lister ◽  
Edy Fachrial ◽  
Sahna Ferdinand Ginting ◽  
Wahyu Widowati ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Seed Extract ◽  
Insulin Levels ◽  
Gnetum Gnemon

The study of safety and skin whitening efficacy of melinjo (Gnetum gnemon L.) seed extract-loaded lipid particle gel

2018 ◽  
Vol 10 (4) ◽  
pp. 432 ◽  
Author(s):  
Sutriyo Sutriyo ◽  
ImaliaNurrachma Ayuningtyas ◽  
Abdul Mun'im
Keyword(s):  
Seed Extract ◽  
Skin Whitening ◽  
Lipid Particle ◽  
Gnetum Gnemon

scholarly journals Inhibitory Activities of Sesame Seed Extract and its Constituents against β-Secretase

2016 ◽  
Vol 11 (11) ◽  
pp. 1934578X1601101 ◽  
Author(s):  
Shinichi Matsumura ◽  
Kazuya Murata ◽  
Nobuhiro Zaima ◽  
Yuri Yoshioka ◽  
Masanori Morimoto ◽  
...  
Keyword(s):  
Oral Administration ◽  
Sesame Seed ◽  
Sesamum Indicum ◽  
Seed Extract ◽  
Plant Resources ◽  
Natural Plant ◽  
Sesame Seeds ◽  
Absorption Experiment ◽  
Inhibitory Activities ◽  
The Brain

The need for a preventive agent against dementia led us to screen natural plant resources. Among the herbs and spices tested, sesame seed prepared from Sesamum indicum seeds showed potent β-secretase inhibitory activity. The active principles were determined to be sesamin and sesamolin, typical lignans in S. indicum. The IC50 values of sesamin and sesamolin were 257 and 140 μM, respectively. These compounds were investigated in a preliminary absorption experiment. After oral administration, these compounds were detected in an intact form in the brain and serum. These results suggest that consumption of sesame seeds may prevent dementia by sesamin and sesamolin, the constituents in sesame seeds.

scholarly journals Resveratrol derivative-rich melinjo (Gnetum gnemon L.) seed extract improves obesity and survival of C57BL/6 mice fed a high-fat diet

2015 ◽  
Vol 79 (12) ◽  
pp. 2044-2049 ◽  
Author(s):  
Tomoki Ikuta ◽  
Shinichiro Saito ◽  
Hiroko Tani ◽  
Tomoki Tatefuji ◽  
Ken Hashimoto
Keyword(s):  
High Fat Diet ◽  
Seed Extract ◽  
High Fat ◽  
Gnetum Gnemon ◽  
Resveratrol Derivative

scholarly journals Quality Evaluation of Melinjo Seeds (Gnetum gnemon L.)Using Digital Image Processing

2018 ◽  
Vol 7 (2) ◽  
pp. 106 ◽  
Author(s):  
Slamet Widodo ◽  
Muhammad Kalili
Keyword(s):  
Image Processing ◽  
Digital Image Processing ◽  
Digital Image ◽  
Quality Evaluation ◽  
Seed Extract ◽  
Raw Material ◽  
Key Factors ◽  
Gnetum Gnemon ◽  
Lighting Systems

Some studies show that melinjo (Gnetum gnemon L.) seed extract contains various active ingredients that are beneficial to human health; even it has been commercialized as a health supplement product. Quality of seeds as raw material becomes one of key factors that determine the quality of product derived from melinjo seed extract. Therefore sorting becomes a critical process. However the sorting of good quality and broken seeds (moldy, chalky and perforated/infected insects) is still done manually with visual observations that tend to be inaccurate and inconsistent. This study aims to develop a new method for evaluation of quality of melinjo seeds based on digital image processing. The image is taken using two lighting systems i.e. frontlight and backlight. The results show that using color features (RGB and HSV) and certain threshold values, good quality and broken seeds can be distinguished by 92.5% and 100% accuracy using frontlight and backlight image respectively. It indicates that digital image processing can be used as an alternative for quality evaluation of melinjo seed.

Safety assessment of melinjo (Gnetum gnemon L.) seed extract: Acute and subchronic toxicity studies

2014 ◽  
Vol 67 ◽  
pp. 230-235 ◽  
Author(s):  
Tomoki Tatefuji ◽  
Miyako Yanagihara ◽  
Shinobu Fukushima ◽  
Ken Hashimoto
Keyword(s):  
Safety Assessment ◽  
Seed Extract ◽  
Subchronic Toxicity ◽  
Toxicity Studies ◽  
Gnetum Gnemon

scholarly journals Antitumor activity of melinjo ( Gnetum gnemon L.) seed extract in human and murine tumor models in vitro and in a colon‐26 tumor‐bearing mouse model in vivo

2015 ◽  
Vol 4 (11) ◽  
pp. 1767-1780 ◽  
Author(s):  
Narayanan K. Narayanan ◽  
Kazuhiro Kunimasa ◽  
Yukio Yamori ◽  
Mari Mori ◽  
Hideki Mori ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Mouse Model ◽  
Seed Extract ◽  
Tumor Bearing Mouse ◽  
Colon 26 ◽  
Murine Tumor ◽  
Tumor Bearing ◽  
Gnetum Gnemon

scholarly journals Study Antidiabetic Effect of Momordica Charantia (bitter gourd) seeds on Alloxan Induced Diabetic Rats

2010 ◽  
Vol 34 (1) ◽  
pp. 165-170
Author(s):  
Auroba M.S. Ibrahem
Keyword(s):  
Oral Administration ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Fasting Blood Glucose ◽  
Treated Group ◽  
Progressive Increase ◽  
Diabetic Rats ◽  
Seed Extract ◽  
Momordica Charantia ◽  
Antidiabetic Effect

The aim of the present study is to investigate the antidiabetic effect of the aqueous extract of Momordica charantia seeds in alloxan - induced diabetic rats. Forty male albino Wistar rats were used, divided randomly into four groups (10 each). Oral administration of the seed extract at a dose of 150 mg/kg B.W. for 30 days showed a significant decrease in fasting blood glucose. Our results were greatly lower after oral administration of aqueous extract of Momordica charantia seeds in alloxan- induced diabetic groups than glibenclamide treated group. Also Momordica charantia extract and glibenclamide administered rats showed progressive increase in body weight

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