Rapid and Semiautomated Method for the Analysis of Veterinary Drug Residues in Honey Based on Turbulent-Flow Liquid Chromatography Coupled to Ultrahigh-Performance Liquid Chromatography–Orbitrap Mass Spectrometry (TFC-UHPLC-Orbitrap-MS)

2013 ◽  
Vol 61 (4) ◽  
pp. 829-839 ◽  
Author(s):  
María M. Aguilera-Luiz ◽  
Roberto Romero-González ◽  
Patricia Plaza-Bolaños ◽  
José L. Martínez Vidal ◽  
Antonia Garrido Frenich
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Turbulent Flow ◽  
Veterinary Drug ◽  
Veterinary Drug Residues ◽  
Drug Residues ◽  
Orbitrap Mass Spectrometry ◽  
Ultrahigh Performance Liquid Chromatography ◽  
Semiautomated Method ◽  
Orbitrap Ms

Development and Validation of a Multiclass Method for the Analysis of Veterinary Drug Residues in Eggs Using Liquid Chromatography-Tandem Mass Spectrometry

2016 ◽  
Vol 10 (4) ◽  
pp. 1063-1077 ◽  
Author(s):  
Flávia Lada Degaut Pontes ◽  
João Cleverson Gasparetto ◽  
Thais Martins Guimarães de Francisco ◽  
Heloise Calzado Goetzke ◽  
Letícia Paula Leonart ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Veterinary Drug ◽  
Tandem Mass ◽  
Veterinary Drug Residues ◽  
Drug Residues ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Development And Validation

Screening of 154 Veterinary Drug Residues in Foods of Animal Origin Using LC-MS/MS, First Action 2020.04

2020 ◽  
Author(s):  
Aurélien Desmarchelier ◽  
Thomas Bessaire ◽  
Marie-Claude Savoy ◽  
Adrienne Tarres ◽  
Claudia Mujahid ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Animal Origin ◽  
Veterinary Drug ◽  
Veterinary Drug Residues ◽  
Drug Residues ◽  
Potential Health ◽  
Expert Review ◽  
Wide Range ◽  
Expert Review Panel

Abstract Background Veterinary drug residues in food are substances (>200 compounds) exhibiting potential health risks for consumers, thus being regulated in national legislations and the Codex Alimentarius. Most of the compounds are regulated based upon a maximum residue limit (MRL) while a few of them are banned in food for humans. The food sector needs a reliable and consensus analytical platform able to monitor these substances in a wide range of food commodities. Objective Several confirmatory methods based on liquid chromatography-mass spectrometry are available in the literature for either screening or quantification of veterinary drug residues in food, but usually applicable to limited scope of matrices. The current work describes the single-laboratory validation (SLV) of a method for screening 154 veterinary drug residues in several food categories. Methods This work describes a streamlined platform making use of liquid chromatography-tandem mass spectrometry (LC-MS/MS) for screening 105 antibiotics, 41 antiparasitics, 5 anti-inflammatory agents and 3 tranquilizers in foods of animal origin. For the best performance across the commodities (dairy-, meat-, fish- and egg-based materials) four method streams were established. As a screening tool, probabilities of detection (PODs) were assessed at the screening target concentration (STC < MRL) and the blank. Results The SLV led to PODs at the STC >94% and PODs in the blank < 4%. Conclusion Performance is in agreement with the acceptance criteria defined in SMPR 2018.010. Highlights The Expert Review Panel approved the present method as AOAC Official First Action 2020.04.

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