scholarly journals Determination of the Concentration of Potential Efflux Pump Inhibitors, Pheophorbide a and Pyropheophorbide a, in the Feces of Animals by Fluorescence Spectroscopy

2012 ◽  
Vol 60 (42) ◽  
pp. 10456-10460 ◽  
Author(s):  
Charles A. Barnes ◽  
Sharon L. Rasmussen ◽  
Jacob W. Petrich ◽  
Mark A. Rasmussen
Keyword(s):  
Fluorescence Spectroscopy ◽  
Efflux Pump ◽  
Pheophorbide A ◽  
Efflux Pump Inhibitors ◽  
Pyropheophorbide A

Determination of pheophorbide a, pyropheophorbide a and phytol

1983 ◽  
Vol 280 ◽  
pp. 188-193 ◽  
Author(s):  
Yuiko Takeda ◽  
Yukio Saito ◽  
Mitsuru Uchiyama
Keyword(s):  
Pheophorbide A ◽  
Pyropheophorbide A

scholarly journals Effects of Chlorophyll-Derived Efflux Pump Inhibitor Pheophorbide a and Pyropheophorbide a on Growth and Macrolide Antibiotic Resistance of Indicator and Anaerobic Swine Manure Bacteria

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Mareike Kraatz ◽  
Terence R. Whitehead ◽  
Michael A. Cotta ◽  
Mark A. Berhow ◽  
Mark A. Rasmussen
Keyword(s):  
Bacterial Resistance ◽  
Efflux Pump ◽  
Growth Parameters ◽  
Swine Manure ◽  
Efflux Pumps ◽  
Resistant Bacteria ◽  
Pheophorbide A ◽  
Efflux Pump Inhibitor ◽  
E Coli ◽  
Pyropheophorbide A

Natural plant compounds, such as the chlorophyll a catabolites pheophorbide a (php) and pyropheophorbide a (pyp), are potentially active in the gastrointestinal tracts and manure of livestock as antimicrobial resistance-modifying agents through inhibition of bacterial efflux pumps. To investigate whether php, a known efflux pump inhibitor, and pyp influence bacterial resistance, we determined their long-term effects on the MICs of erythromycin for reference strains of clinically relevant indicator bacteria with macrolide or multidrug resistance efflux pumps. Pyp reduced the final MIC endpoint for Staphylococcus (S.) aureus and Escherichia (E.) coli by up to 1536 and 1024 μg erythromycin mL−1 or 1.4- and 1.2-fold, respectively. Estimation of growth parameters of S. aureus revealed that pyp exerted an intrinsic inhibitory effect under anaerobic conditions and was synergistically active, thereby potentiating the effect of erythromycin and partially reversing high-level erythromycin resistance. Anaerobe colony counts of total and erythromycin-resistant bacteria from stored swine manure samples tended to be lower in the presence of pyp. Tylosin, php, and pyp were not detectable by HPLC in the manure or medium. This is the first study showing that pyp affects growth and the level of sensitivity to erythromycin of S. aureus, E. coli, and anaerobic manure bacteria.

scholarly journals HPLC Determination of Pheophorbide a and Pyropheophorbide a in Dried Laver Product Implicated in Food Poisoning

2005 ◽  
Vol 46 (2) ◽  
pp. 45-48 ◽  
Author(s):  
Deng-Fwu HWANG ◽  
Yu-Shia TSAI ◽  
Shin-Shoug CHOU ◽  
Shiu-Mei LIU ◽  
Jiunn-Tzong WU ◽  
...  
Keyword(s):  
Food Poisoning ◽  
Hplc Determination ◽  
Pheophorbide A ◽  
Dried Laver ◽  
Pyropheophorbide A

Screening of Natural Products and Derivatives for the Identification of RND Efflux Pump Inhibitors

2016 ◽  
Vol 19 (9) ◽  
pp. 705-713 ◽  
Author(s):  
Debarati Choudhury ◽  
Anupam Talukdar ◽  
Pankaj Chetia ◽  
Amitabha Bhattacharjee ◽  
Manabendra Choudhury
Keyword(s):  
Natural Products ◽  
Efflux Pump ◽  
Rnd Efflux Pump ◽  
Efflux Pump Inhibitors

Virtual Screening for Novel Staphylococcus Aureus NorA Efflux Pump Inhibitors From Natural Products

2015 ◽  
Vol 11 (2) ◽  
pp. 135-155 ◽  
Author(s):  
Khac-Minh Thai ◽  
Trieu-Du Ngo ◽  
Thien-Vy Phan ◽  
Thanh-Dao Tran ◽  
Ngoc-Vinh Nguyen ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Natural Products ◽  
Virtual Screening ◽  
Efflux Pump ◽  
Efflux Pump Inhibitors

scholarly journals From quinoline to quinazoline‐based S. aureus NorA efflux pump inhibitors by coupling focused scaffold hopping approach and pharmacophore search

ChemMedChem ◽  
2021 ◽  
Author(s):  
Nicholas Cedraro ◽  
Rolando Cannalire ◽  
Andrea Astolfi ◽  
Gianmarco Mangiaterra ◽  
Tommaso Felicetti ◽  
...  
Keyword(s):  
Efflux Pump ◽  
Scaffold Hopping ◽  
Efflux Pump Inhibitors

scholarly journals Fluorescence spectroscopy for the determination of reconstitution time of an in-vial lyophilised product

2021 ◽  
Vol 597 ◽  
pp. 120368
Author(s):  
Khaled ElKassas ◽  
Krishnakumar Chullipalliyalil ◽  
Michael McAuliffe ◽  
Sonja Vucen ◽  
Abina Crean
Keyword(s):  
Fluorescence Spectroscopy
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